LFRFamides: a novel family of parasitation-induced -RFamide neuropeptides that inhibit the activity of neuroendocrine cells in Lymnaea stagnalis

R.M. Hoek; K.W. Li; J. van Minnen; J.C. Lodder; M. de Jong-Brink; A.B. Smit; R.E. van Kesteren

doi:10.1111/j.1471-4159.2004.02927.x

LFRFamides: a novel family of parasitation-induced -RFamide neuropeptides that inhibit the activity of neuroendocrine cells in Lymnaea stagnalis

R.M. Hoek, K.W. Li, J. van Minnen, J.C. Lodder, M. de Jong-Brink, A.B. Smit, R.E. van Kesteren

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

We report the characterization of a cDNA encoding a novel -RFamide neuropeptide precursor that is up-regulated during parasitation in the snail Lymnaea stagnalis. Processing of this precursor yields five structurally related neuropeptides, all but one ending with the C-terminal sequence -LFRFamide, as was confirmed by direct mass spectrometry of brain tissue. The LFRFamide gene is expressed in a small cluster of neurons in each buccal ganglion, three small clusters in each cerebral ganglion, and one cluster in each lateral lobe of the cerebral ganglia. Application of two of the LFRFamide peptides to neuroendocrine cells that control either growth and metabolism or reproduction induced similar hyperpolarizing K

Original language	English
Pages (from-to)	1073-1080
Number of pages	8
Journal	Journal of Neurochemistry
Volume	92
Issue number	5
DOIs	https://doi.org/10.1111/j.1471-4159.2004.02927.x
Publication status	Published - 2005

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title = "LFRFamides: a novel family of parasitation-induced -RFamide neuropeptides that inhibit the activity of neuroendocrine cells in Lymnaea stagnalis",

abstract = "We report the characterization of a cDNA encoding a novel -RFamide neuropeptide precursor that is up-regulated during parasitation in the snail Lymnaea stagnalis. Processing of this precursor yields five structurally related neuropeptides, all but one ending with the C-terminal sequence -LFRFamide, as was confirmed by direct mass spectrometry of brain tissue. The LFRFamide gene is expressed in a small cluster of neurons in each buccal ganglion, three small clusters in each cerebral ganglion, and one cluster in each lateral lobe of the cerebral ganglia. Application of two of the LFRFamide peptides to neuroendocrine cells that control either growth and metabolism or reproduction induced similar hyperpolarizing K",

author = "R.M. Hoek and K.W. Li and {van Minnen}, J. and J.C. Lodder and {de Jong-Brink}, M. and A.B. Smit and {van Kesteren}, R.E.",

year = "2005",

doi = "10.1111/j.1471-4159.2004.02927.x",

language = "English",

volume = "92",

pages = "1073--1080",

journal = "Journal of Neurochemistry",

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TY - JOUR

T1 - LFRFamides: a novel family of parasitation-induced -RFamide neuropeptides that inhibit the activity of neuroendocrine cells in Lymnaea stagnalis

AU - Hoek, R.M.

AU - Li, K.W.

AU - van Minnen, J.

AU - Lodder, J.C.

AU - de Jong-Brink, M.

AU - Smit, A.B.

AU - van Kesteren, R.E.

PY - 2005

Y1 - 2005

N2 - We report the characterization of a cDNA encoding a novel -RFamide neuropeptide precursor that is up-regulated during parasitation in the snail Lymnaea stagnalis. Processing of this precursor yields five structurally related neuropeptides, all but one ending with the C-terminal sequence -LFRFamide, as was confirmed by direct mass spectrometry of brain tissue. The LFRFamide gene is expressed in a small cluster of neurons in each buccal ganglion, three small clusters in each cerebral ganglion, and one cluster in each lateral lobe of the cerebral ganglia. Application of two of the LFRFamide peptides to neuroendocrine cells that control either growth and metabolism or reproduction induced similar hyperpolarizing K

AB - We report the characterization of a cDNA encoding a novel -RFamide neuropeptide precursor that is up-regulated during parasitation in the snail Lymnaea stagnalis. Processing of this precursor yields five structurally related neuropeptides, all but one ending with the C-terminal sequence -LFRFamide, as was confirmed by direct mass spectrometry of brain tissue. The LFRFamide gene is expressed in a small cluster of neurons in each buccal ganglion, three small clusters in each cerebral ganglion, and one cluster in each lateral lobe of the cerebral ganglia. Application of two of the LFRFamide peptides to neuroendocrine cells that control either growth and metabolism or reproduction induced similar hyperpolarizing K

U2 - 10.1111/j.1471-4159.2004.02927.x

DO - 10.1111/j.1471-4159.2004.02927.x

M3 - Article

SN - 0022-3042

VL - 92

SP - 1073

EP - 1080

JO - Journal of Neurochemistry

JF - Journal of Neurochemistry

IS - 5

ER -

LFRFamides: a novel family of parasitation-induced -RFamide neuropeptides that inhibit the activity of neuroendocrine cells in Lymnaea stagnalis

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