Linear distributed source modeling of local field potentials recorded with intra-cortical electrode arrays

R. Hindriks, J. Schmiedt, X.D. Arsiwalla, A. Peter, P.F.M.J. Verschure, P. Fries, M.C. Schmid, G. Deco

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Planar intra-cortical electrode (Utah) arrays provide a unique window into the spatial organization of cortical activity. Reconstruction of the current source density (CSD) underlying such recordings, however, requires “inverting” Poisson’s equation. For inter-laminar recordings, this is commonly done by the CSD method, which consists in taking the second-order spatial derivative of the recorded local field potentials (LFPs). Although the CSD method has been tremendously successful in mapping the current generators underlying inter-laminar LFPs, its application to planar recordings is more challenging. While for inter-laminar recordings the CSD method seems reasonably robust against violations of its assumptions, is it unclear as to what extent this holds for planar recordings. One of the objectives of this study is to characterize the conditions under which the CSD method can be successfully applied to Utah array data. Using forward modeling, we find that for spatially coherent CSDs, the CSD method yields inaccurate reconstructions due to volume-conducted contamination from currents in deeper cortical layers. An alternative approach is to “invert” a constructed forward model. The advantage of this approach is that any a priori knowledge about the geometrical and electrical properties of the tissue can be taken into account. Although several inverse methods have been proposed for LFP data, the applicability of existing electroencephalographic (EEG) and magnetoencephalographic (MEG) inverse methods to LFP data is largely unexplored. Another objective of our study therefore, is to assess the applicability of the most commonly used EEG/MEG inverse methods to Utah array data. Our main conclusion is that these inverse methods provide more accurate CSD reconstructions than the CSD method. We illustrate the inverse methods using event-related potentials recorded from primary visual cortex of a macaque monkey during a motion discrimination task.
LanguageEnglish
Article numbere0187490
Pages1-29
Number of pages29
JournalPLoS ONE
Volume12
Issue number12
DOIs
Publication statusPublished - 18 Dec 2017
Externally publishedYes

Fingerprint

Poisson equation
electrodes
Electrodes
Electric properties
Contamination
Tissue
Derivatives
methodology
electrical properties
generators (equipment)
Macaca
Visual Cortex
Evoked Potentials
Haplorhini
monkeys

Cite this

Hindriks, R., Schmiedt, J., Arsiwalla, X. D., Peter, A., Verschure, P. F. M. J., Fries, P., ... Deco, G. (2017). Linear distributed source modeling of local field potentials recorded with intra-cortical electrode arrays. PLoS ONE, 12(12), 1-29. [e0187490]. https://doi.org/10.1371/journal.pone.0187490
Hindriks, R. ; Schmiedt, J. ; Arsiwalla, X.D. ; Peter, A. ; Verschure, P.F.M.J. ; Fries, P. ; Schmid, M.C. ; Deco, G. / Linear distributed source modeling of local field potentials recorded with intra-cortical electrode arrays. In: PLoS ONE. 2017 ; Vol. 12, No. 12. pp. 1-29.
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Hindriks, R, Schmiedt, J, Arsiwalla, XD, Peter, A, Verschure, PFMJ, Fries, P, Schmid, MC & Deco, G 2017, 'Linear distributed source modeling of local field potentials recorded with intra-cortical electrode arrays', PLoS ONE, vol. 12, no. 12, e0187490, pp. 1-29. https://doi.org/10.1371/journal.pone.0187490

Linear distributed source modeling of local field potentials recorded with intra-cortical electrode arrays. / Hindriks, R.; Schmiedt, J.; Arsiwalla, X.D.; Peter, A.; Verschure, P.F.M.J.; Fries, P.; Schmid, M.C.; Deco, G.

In: PLoS ONE, Vol. 12, No. 12, e0187490, 18.12.2017, p. 1-29.

Research output: Contribution to JournalArticleAcademicpeer-review

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