Linoleic acid-derived oxylipins and isoprostanes plasma levels are influenced by 1,25-Dihydroxyvitamin D levels in middle-aged sedentary adults: The FIT-AGEING study

Héctor Vázquez-Lorente; Lucas Jurado-Fasoli; Isabelle Kohler; Xinyu Di; Wei Yang; Francisco J. Osuna-Prieto; Sardor Asadov; José F. Frias-Rodríguez; Manuel J. Castillo-Garzón; Francisco J. Amaro-Gahete

doi:10.1016/j.exger.2022.111954

Linoleic acid-derived oxylipins and isoprostanes plasma levels are influenced by 1,25-Dihydroxyvitamin D levels in middle-aged sedentary adults: The FIT-AGEING study

Héctor Vázquez-Lorente^*, Lucas Jurado-Fasoli, Isabelle Kohler, Xinyu Di, Wei Yang, Francisco J. Osuna-Prieto, Sardor Asadov, José F. Frias-Rodríguez, Manuel J. Castillo-Garzón, Francisco J. Amaro-Gahete

^*Corresponding author for this work

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Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Introduction: Vitamin D – concretely its active form 1,25-dihydroxyvitamin D (1,25(OH)₂D) – maintains several physiological processes. Oxylipins are oxidized lipids derived from ω-6 and ω-3 polyunsaturated fatty acids involved in inflammation. Little is known about the association of 1,25(OH)₂D with inflammatory parameters in middle-aged populations – who could be at risk of vitamin D deficiency –. The aim of this study was to investigate the relationship between 1,25(OH)₂D plasma levels with circulating white blood cells, platelets counts and oxylipins levels. Materials and methods: A total of 74 (53 % women) middle-aged (40–65 years old) adults were recruited for this cross-sectional study. 1,25(OH)₂D plasma levels were measured using an immunochemiluminometric assay. White blood cells and platelets were analyzed by hemocytometry. ω-6 and ω-3 oxylipins plasma levels were measured using liquid chromatography - tandem mass spectrometry. Simple and multiple linear regression models, and Pearson correlation analyses, were performed to study the association of 1,25(OH)₂D levels with WBC and platelets counts, and oxylipins, respectively. Results: 1,25(OH)₂D plasma levels were positively related with linoleic acid-derived oxylipins and isoprostanes plasma levels, whereas an inverse relationship with dihomo-γ-linolenic acid/linoleic acid and arachidonic acid/linoleic acid ratios was unveiled. No significant associations were observed for circulating ω-3 oxylipins, white blood cells levels or platelets count. Conclusions: Linoleic acid-derived oxylipins and isoprostanes plasma levels may be influenced by 1,25(OH)₂D plasma levels. Further investigations are needed to elucidate the impact of other vitamin D forms upon circulating oxylipins levels.

Original language	English
Article number	111954
Pages (from-to)	1-8
Number of pages	8
Journal	Experimental Gerontology
Volume	169
Early online date	17 Sept 2022
DOIs	https://doi.org/10.1016/j.exger.2022.111954
Publication status	Published - Nov 2022

Bibliographical note

Funding Information:
The authors would like to thank all the participants of this study for their time and effort. Funding for open access charge: Universidad de Granada / CBUA .

Funding Information:
Héctor Vázquez-Lorente and Lucas Jurado-Fasoli are under a FPU fellowship from the Spanish Ministry of Education . Xinyu Di (CSC, No. 201607060017 ) and Wei Yang (CSC, No. 201707060012 ) are supported by the Chinese Scholarship Council .

Publisher Copyright:
© 2022 The Authors

Funding

The authors would like to thank all the participants of this study for their time and effort. Funding for open access charge: Universidad de Granada / CBUA . Héctor Vázquez-Lorente and Lucas Jurado-Fasoli are under a FPU fellowship from the Spanish Ministry of Education . Xinyu Di (CSC, No. 201607060017 ) and Wei Yang (CSC, No. 201707060012 ) are supported by the Chinese Scholarship Council .

Keywords

Aging
Inflammageing
Lipid mediators
Oxylipins
Vitamin D

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10.1016/j.exger.2022.111954

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Vázquez-Lorente, H., Jurado-Fasoli, L., Kohler, I., Di, X., Yang, W., Osuna-Prieto, F. J., Asadov, S., Frias-Rodríguez, J. F., Castillo-Garzón, M. J., & Amaro-Gahete, F. J. (2022). Linoleic acid-derived oxylipins and isoprostanes plasma levels are influenced by 1,25-Dihydroxyvitamin D levels in middle-aged sedentary adults: The FIT-AGEING study. Experimental Gerontology, 169, 1-8. Article 111954. https://doi.org/10.1016/j.exger.2022.111954

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title = "Linoleic acid-derived oxylipins and isoprostanes plasma levels are influenced by 1,25-Dihydroxyvitamin D levels in middle-aged sedentary adults: The FIT-AGEING study",

abstract = "Introduction: Vitamin D – concretely its active form 1,25-dihydroxyvitamin D (1,25(OH)2D) – maintains several physiological processes. Oxylipins are oxidized lipids derived from ω-6 and ω-3 polyunsaturated fatty acids involved in inflammation. Little is known about the association of 1,25(OH)2D with inflammatory parameters in middle-aged populations – who could be at risk of vitamin D deficiency –. The aim of this study was to investigate the relationship between 1,25(OH)2D plasma levels with circulating white blood cells, platelets counts and oxylipins levels. Materials and methods: A total of 74 (53 % women) middle-aged (40–65 years old) adults were recruited for this cross-sectional study. 1,25(OH)2D plasma levels were measured using an immunochemiluminometric assay. White blood cells and platelets were analyzed by hemocytometry. ω-6 and ω-3 oxylipins plasma levels were measured using liquid chromatography - tandem mass spectrometry. Simple and multiple linear regression models, and Pearson correlation analyses, were performed to study the association of 1,25(OH)2D levels with WBC and platelets counts, and oxylipins, respectively. Results: 1,25(OH)2D plasma levels were positively related with linoleic acid-derived oxylipins and isoprostanes plasma levels, whereas an inverse relationship with dihomo-γ-linolenic acid/linoleic acid and arachidonic acid/linoleic acid ratios was unveiled. No significant associations were observed for circulating ω-3 oxylipins, white blood cells levels or platelets count. Conclusions: Linoleic acid-derived oxylipins and isoprostanes plasma levels may be influenced by 1,25(OH)2D plasma levels. Further investigations are needed to elucidate the impact of other vitamin D forms upon circulating oxylipins levels.",

keywords = "Aging, Inflammageing, Lipid mediators, Oxylipins, Vitamin D",

author = "H{\'e}ctor V{\'a}zquez-Lorente and Lucas Jurado-Fasoli and Isabelle Kohler and Xinyu Di and Wei Yang and Osuna-Prieto, {Francisco J.} and Sardor Asadov and Frias-Rodr{\'i}guez, {Jos{\'e} F.} and Castillo-Garz{\'o}n, {Manuel J.} and Amaro-Gahete, {Francisco J.}",

note = "Funding Information: The authors would like to thank all the participants of this study for their time and effort. Funding for open access charge: Universidad de Granada / CBUA . Funding Information: H{\'e}ctor V{\'a}zquez-Lorente and Lucas Jurado-Fasoli are under a FPU fellowship from the Spanish Ministry of Education . Xinyu Di (CSC, No. 201607060017 ) and Wei Yang (CSC, No. 201707060012 ) are supported by the Chinese Scholarship Council . Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = nov,

doi = "10.1016/j.exger.2022.111954",

language = "English",

volume = "169",

pages = "1--8",

journal = "Experimental Gerontology",

issn = "0531-5565",

publisher = "Elsevier Inc.",

}

Vázquez-Lorente, H, Jurado-Fasoli, L, Kohler, I, Di, X, Yang, W, Osuna-Prieto, FJ, Asadov, S, Frias-Rodríguez, JF, Castillo-Garzón, MJ & Amaro-Gahete, FJ 2022, 'Linoleic acid-derived oxylipins and isoprostanes plasma levels are influenced by 1,25-Dihydroxyvitamin D levels in middle-aged sedentary adults: The FIT-AGEING study', Experimental Gerontology, vol. 169, 111954, pp. 1-8. https://doi.org/10.1016/j.exger.2022.111954

Linoleic acid-derived oxylipins and isoprostanes plasma levels are influenced by 1,25-Dihydroxyvitamin D levels in middle-aged sedentary adults: The FIT-AGEING study. / Vázquez-Lorente, Héctor; Jurado-Fasoli, Lucas; Kohler, Isabelle et al.
In: Experimental Gerontology, Vol. 169, 111954, 11.2022, p. 1-8.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Linoleic acid-derived oxylipins and isoprostanes plasma levels are influenced by 1,25-Dihydroxyvitamin D levels in middle-aged sedentary adults

T2 - The FIT-AGEING study

AU - Vázquez-Lorente, Héctor

AU - Jurado-Fasoli, Lucas

AU - Kohler, Isabelle

AU - Di, Xinyu

AU - Yang, Wei

AU - Osuna-Prieto, Francisco J.

AU - Asadov, Sardor

AU - Frias-Rodríguez, José F.

AU - Castillo-Garzón, Manuel J.

AU - Amaro-Gahete, Francisco J.

N1 - Funding Information: The authors would like to thank all the participants of this study for their time and effort. Funding for open access charge: Universidad de Granada / CBUA . Funding Information: Héctor Vázquez-Lorente and Lucas Jurado-Fasoli are under a FPU fellowship from the Spanish Ministry of Education . Xinyu Di (CSC, No. 201607060017 ) and Wei Yang (CSC, No. 201707060012 ) are supported by the Chinese Scholarship Council . Publisher Copyright: © 2022 The Authors

PY - 2022/11

Y1 - 2022/11

N2 - Introduction: Vitamin D – concretely its active form 1,25-dihydroxyvitamin D (1,25(OH)2D) – maintains several physiological processes. Oxylipins are oxidized lipids derived from ω-6 and ω-3 polyunsaturated fatty acids involved in inflammation. Little is known about the association of 1,25(OH)2D with inflammatory parameters in middle-aged populations – who could be at risk of vitamin D deficiency –. The aim of this study was to investigate the relationship between 1,25(OH)2D plasma levels with circulating white blood cells, platelets counts and oxylipins levels. Materials and methods: A total of 74 (53 % women) middle-aged (40–65 years old) adults were recruited for this cross-sectional study. 1,25(OH)2D plasma levels were measured using an immunochemiluminometric assay. White blood cells and platelets were analyzed by hemocytometry. ω-6 and ω-3 oxylipins plasma levels were measured using liquid chromatography - tandem mass spectrometry. Simple and multiple linear regression models, and Pearson correlation analyses, were performed to study the association of 1,25(OH)2D levels with WBC and platelets counts, and oxylipins, respectively. Results: 1,25(OH)2D plasma levels were positively related with linoleic acid-derived oxylipins and isoprostanes plasma levels, whereas an inverse relationship with dihomo-γ-linolenic acid/linoleic acid and arachidonic acid/linoleic acid ratios was unveiled. No significant associations were observed for circulating ω-3 oxylipins, white blood cells levels or platelets count. Conclusions: Linoleic acid-derived oxylipins and isoprostanes plasma levels may be influenced by 1,25(OH)2D plasma levels. Further investigations are needed to elucidate the impact of other vitamin D forms upon circulating oxylipins levels.

AB - Introduction: Vitamin D – concretely its active form 1,25-dihydroxyvitamin D (1,25(OH)2D) – maintains several physiological processes. Oxylipins are oxidized lipids derived from ω-6 and ω-3 polyunsaturated fatty acids involved in inflammation. Little is known about the association of 1,25(OH)2D with inflammatory parameters in middle-aged populations – who could be at risk of vitamin D deficiency –. The aim of this study was to investigate the relationship between 1,25(OH)2D plasma levels with circulating white blood cells, platelets counts and oxylipins levels. Materials and methods: A total of 74 (53 % women) middle-aged (40–65 years old) adults were recruited for this cross-sectional study. 1,25(OH)2D plasma levels were measured using an immunochemiluminometric assay. White blood cells and platelets were analyzed by hemocytometry. ω-6 and ω-3 oxylipins plasma levels were measured using liquid chromatography - tandem mass spectrometry. Simple and multiple linear regression models, and Pearson correlation analyses, were performed to study the association of 1,25(OH)2D levels with WBC and platelets counts, and oxylipins, respectively. Results: 1,25(OH)2D plasma levels were positively related with linoleic acid-derived oxylipins and isoprostanes plasma levels, whereas an inverse relationship with dihomo-γ-linolenic acid/linoleic acid and arachidonic acid/linoleic acid ratios was unveiled. No significant associations were observed for circulating ω-3 oxylipins, white blood cells levels or platelets count. Conclusions: Linoleic acid-derived oxylipins and isoprostanes plasma levels may be influenced by 1,25(OH)2D plasma levels. Further investigations are needed to elucidate the impact of other vitamin D forms upon circulating oxylipins levels.

KW - Aging

KW - Inflammageing

KW - Lipid mediators

KW - Oxylipins

KW - Vitamin D

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DO - 10.1016/j.exger.2022.111954

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SN - 0531-5565

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Linoleic acid-derived oxylipins and isoprostanes plasma levels are influenced by 1,25-Dihydroxyvitamin D levels in middle-aged sedentary adults: The FIT-AGEING study

Abstract

Bibliographical note

Funding

Keywords

Access to Document

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