Lipid-soluble 3-pyridinol antioxidants spare alpha-tocopherol and do not efficiently mediate peroxidation of cholesterol esters in human low-density lipoprotein

Hye-Young Kim; Derek A Pratt; Jennifer R Seal; Maikel Wijtmans; Ned A Porter

doi:10.1021/jm0507173

Lipid-soluble 3-pyridinol antioxidants spare alpha-tocopherol and do not efficiently mediate peroxidation of cholesterol esters in human low-density lipoprotein

Hye-Young Kim
, Derek A Pratt
, Jennifer R Seal
, Maikel Wijtmans
, Ned A Porter

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Because alpha-tocopherol (alpha-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare alpha-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.

Original language	English
Pages (from-to)	6787-9
Number of pages	3
Journal	Journal of Medicinal Chemistry
Volume	48
Issue number	22
DOIs	https://doi.org/10.1021/jm0507173
Publication status	Published - 3 Nov 2005
Externally published	Yes

Keywords

Antioxidants
Humans
Lipid Peroxidation
Lipoproteins, LDL
Pyridines
Structure-Activity Relationship
Tryptophan
alpha-Tocopherol
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Access to Document

10.1021/jm0507173

Persistent URL (handle)

Persistent link

Cite this

@article{0dcdba2927f54e77be6d839d74c82572,

title = "Lipid-soluble 3-pyridinol antioxidants spare alpha-tocopherol and do not efficiently mediate peroxidation of cholesterol esters in human low-density lipoprotein",

abstract = "Because alpha-tocopherol (alpha-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare alpha-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.",

keywords = "Antioxidants, Humans, Lipid Peroxidation, Lipoproteins, LDL, Pyridines, Structure-Activity Relationship, Tryptophan, alpha-Tocopherol, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.",

author = "Hye-Young Kim and Pratt, \{Derek A\} and Seal, \{Jennifer R\} and Maikel Wijtmans and Porter, \{Ned A\}",

year = "2005",

month = nov,

day = "3",

doi = "10.1021/jm0507173",

language = "English",

volume = "48",

pages = "6787--9",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "22",

}

Lipid-soluble 3-pyridinol antioxidants spare alpha-tocopherol and do not efficiently mediate peroxidation of cholesterol esters in human low-density lipoprotein. / Kim, Hye-Young; Pratt, Derek A; Seal, Jennifer R et al.
In: Journal of Medicinal Chemistry, Vol. 48, No. 22, 03.11.2005, p. 6787-9.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Lipid-soluble 3-pyridinol antioxidants spare alpha-tocopherol and do not efficiently mediate peroxidation of cholesterol esters in human low-density lipoprotein

AU - Kim, Hye-Young

AU - Pratt, Derek A

AU - Seal, Jennifer R

AU - Wijtmans, Maikel

AU - Porter, Ned A

PY - 2005/11/3

Y1 - 2005/11/3

N2 - Because alpha-tocopherol (alpha-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare alpha-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.

AB - Because alpha-tocopherol (alpha-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare alpha-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.

KW - Antioxidants

KW - Humans

KW - Lipid Peroxidation

KW - Lipoproteins, LDL

KW - Pyridines

KW - Structure-Activity Relationship

KW - Tryptophan

KW - alpha-Tocopherol

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, Non-P.H.S.

KW - Research Support, U.S. Gov't, P.H.S.

UR - https://www.scopus.com/pages/publications/27444435355

UR - https://www.scopus.com/pages/publications/27444435355#tab=citedBy

U2 - 10.1021/jm0507173

DO - 10.1021/jm0507173

M3 - Article

C2 - 16250637

SN - 0022-2623

VL - 48

SP - 6787

EP - 6789

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 22

ER -

Lipid-soluble 3-pyridinol antioxidants spare alpha-tocopherol and do not efficiently mediate peroxidation of cholesterol esters in human low-density lipoprotein

Abstract

Keywords

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this