Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect A beta aggregation features and cross the blood-brain-barrier: Implications for therapy of Alzheimer disease

l. Bana; S. Minniti; S. Sesana; V. Zambelli; A. Cagnotto; A. Orlando; M. Cazzaniga; R. Zwart; W. Scheper; M. Masserini; F. Re

doi:10.1016/j.nano.2013.12.001

Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect A beta aggregation features and cross the blood-brain-barrier: Implications for therapy of Alzheimer disease

l. Bana, S. Minniti, S. Sesana, V. Zambelli, A. Cagnotto, A. Orlando, M. Cazzaniga, R. Zwart, W. Scheper, M. Masserini, F. Re

Functional Genomics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Targeting amyloid-β peptide (Aβ) within the brain is a strategy actively sought for therapy of Alzheimer's disease (AD). We investigated the ability of liposomes bi-functionalized with phosphatidic acid and with a modified ApoE-derived peptide (mApoE-PA-LIP) to affect Aβ aggregation/disaggregation features and to cross in vitro and in vivo the blood-brain barrier (BBB). Surface plasmon resonance showed that bi-functionalized liposomes strongly bind Aβ (k

Original language	English
Pages (from-to)	1583-1590
Journal	Nanomedicine: Nanotechnology, Biology and Medicine
Volume	10
Issue number	7
DOIs	https://doi.org/10.1016/j.nano.2013.12.001
Publication status	Published - 2014

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10.1016/j.nano.2013.12.001

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Bana, L., Minniti, S., Sesana, S., Zambelli, V., Cagnotto, A., Orlando, A., Cazzaniga, M., Zwart, R., Scheper, W., Masserini, M., & Re, F. (2014). Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect A beta aggregation features and cross the blood-brain-barrier: Implications for therapy of Alzheimer disease. Nanomedicine: Nanotechnology, Biology and Medicine, 10(7), 1583-1590. https://doi.org/10.1016/j.nano.2013.12.001

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title = "Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect A beta aggregation features and cross the blood-brain-barrier: Implications for therapy of Alzheimer disease",

abstract = "Targeting amyloid-β peptide (Aβ) within the brain is a strategy actively sought for therapy of Alzheimer's disease (AD). We investigated the ability of liposomes bi-functionalized with phosphatidic acid and with a modified ApoE-derived peptide (mApoE-PA-LIP) to affect Aβ aggregation/disaggregation features and to cross in vitro and in vivo the blood-brain barrier (BBB). Surface plasmon resonance showed that bi-functionalized liposomes strongly bind Aβ (k",

author = "l. Bana and S. Minniti and S. Sesana and V. Zambelli and A. Cagnotto and A. Orlando and M. Cazzaniga and R. Zwart and W. Scheper and M. Masserini and F. Re",

year = "2014",

doi = "10.1016/j.nano.2013.12.001",

language = "English",

volume = "10",

pages = "1583--1590",

journal = "Nanomedicine: Nanotechnology, Biology and Medicine",

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Bana, L, Minniti, S, Sesana, S, Zambelli, V, Cagnotto, A, Orlando, A, Cazzaniga, M, Zwart, R, Scheper, W, Masserini, M & Re, F 2014, 'Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect A beta aggregation features and cross the blood-brain-barrier: Implications for therapy of Alzheimer disease', Nanomedicine: Nanotechnology, Biology and Medicine, vol. 10, no. 7, pp. 1583-1590. https://doi.org/10.1016/j.nano.2013.12.001

Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect A beta aggregation features and cross the blood-brain-barrier: Implications for therapy of Alzheimer disease. / Bana, l.; Minniti, S.; Sesana, S. et al.
In: Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 10, No. 7, 2014, p. 1583-1590.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect A beta aggregation features and cross the blood-brain-barrier: Implications for therapy of Alzheimer disease

AU - Bana, l.

AU - Minniti, S.

AU - Sesana, S.

AU - Zambelli, V.

AU - Cagnotto, A.

AU - Orlando, A.

AU - Cazzaniga, M.

AU - Zwart, R.

AU - Scheper, W.

AU - Masserini, M.

AU - Re, F.

PY - 2014

Y1 - 2014

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AB - Targeting amyloid-β peptide (Aβ) within the brain is a strategy actively sought for therapy of Alzheimer's disease (AD). We investigated the ability of liposomes bi-functionalized with phosphatidic acid and with a modified ApoE-derived peptide (mApoE-PA-LIP) to affect Aβ aggregation/disaggregation features and to cross in vitro and in vivo the blood-brain barrier (BBB). Surface plasmon resonance showed that bi-functionalized liposomes strongly bind Aβ (k

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DO - 10.1016/j.nano.2013.12.001

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SP - 1583

EP - 1590

JO - Nanomedicine: Nanotechnology, Biology and Medicine

JF - Nanomedicine: Nanotechnology, Biology and Medicine

IS - 7

ER -

Bana L, Minniti S, Sesana S, Zambelli V, Cagnotto A, Orlando A et al. Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect A beta aggregation features and cross the blood-brain-barrier: Implications for therapy of Alzheimer disease. Nanomedicine: Nanotechnology, Biology and Medicine. 2014;10(7):1583-1590. doi: 10.1016/j.nano.2013.12.001

Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect A beta aggregation features and cross the blood-brain-barrier: Implications for therapy of Alzheimer disease

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