Liquid chromatography with luminol- based electrochemiluminescence detection. Determination of histamine.

O.M. Steijger; D.A. Kamminga; A. Brummelhuis; H. Lingeman

doi:10.1016/S0021-9673(97)01083-2

Liquid chromatography with luminol- based electrochemiluminescence detection. Determination of histamine.

O.M. Steijger, D.A. Kamminga, A. Brummelhuis, H. Lingeman

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The liquid chromatographic determination of histamine was achieved by precolumn derivatization with N-(4-aminobutyl)-N-ethylisoluminol isothiocyanate and electrochemiluminescence detection. Detection was carried out using postcolumn on-line electrochemical reagent generation and oxidation of the derivatized analyte at a gold gauze working electrode built in the flow cell of the detector. With this on-line method a detection limit of 1.5 pmol (S/N = 3) of histamine was obtained. The method was linear in the range 0.5-10 nmol and the repeatability of the method was satisfactory (R.S.D. = 13.7% and 3.7% at the 0.5 and 5 nmol level, respectively).

Original language	English
Pages (from-to)	57-66
Journal	Journal of Chromatography A
Volume	799
DOIs	https://doi.org/10.1016/S0021-9673(97)01083-2
Publication status	Published - 1998

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title = "Liquid chromatography with luminol- based electrochemiluminescence detection. Determination of histamine.",

abstract = "The liquid chromatographic determination of histamine was achieved by precolumn derivatization with N-(4-aminobutyl)-N-ethylisoluminol isothiocyanate and electrochemiluminescence detection. Detection was carried out using postcolumn on-line electrochemical reagent generation and oxidation of the derivatized analyte at a gold gauze working electrode built in the flow cell of the detector. With this on-line method a detection limit of 1.5 pmol (S/N = 3) of histamine was obtained. The method was linear in the range 0.5-10 nmol and the repeatability of the method was satisfactory (R.S.D. = 13.7% and 3.7% at the 0.5 and 5 nmol level, respectively).",

author = "O.M. Steijger and D.A. Kamminga and A. Brummelhuis and H. Lingeman",

year = "1998",

doi = "10.1016/S0021-9673(97)01083-2",

language = "English",

volume = "799",

pages = "57--66",

journal = "Journal of Chromatography A",

issn = "0021-9673",

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T1 - Liquid chromatography with luminol- based electrochemiluminescence detection. Determination of histamine.

AU - Steijger, O.M.

AU - Kamminga, D.A.

AU - Brummelhuis, A.

AU - Lingeman, H.

PY - 1998

Y1 - 1998

N2 - The liquid chromatographic determination of histamine was achieved by precolumn derivatization with N-(4-aminobutyl)-N-ethylisoluminol isothiocyanate and electrochemiluminescence detection. Detection was carried out using postcolumn on-line electrochemical reagent generation and oxidation of the derivatized analyte at a gold gauze working electrode built in the flow cell of the detector. With this on-line method a detection limit of 1.5 pmol (S/N = 3) of histamine was obtained. The method was linear in the range 0.5-10 nmol and the repeatability of the method was satisfactory (R.S.D. = 13.7% and 3.7% at the 0.5 and 5 nmol level, respectively).

AB - The liquid chromatographic determination of histamine was achieved by precolumn derivatization with N-(4-aminobutyl)-N-ethylisoluminol isothiocyanate and electrochemiluminescence detection. Detection was carried out using postcolumn on-line electrochemical reagent generation and oxidation of the derivatized analyte at a gold gauze working electrode built in the flow cell of the detector. With this on-line method a detection limit of 1.5 pmol (S/N = 3) of histamine was obtained. The method was linear in the range 0.5-10 nmol and the repeatability of the method was satisfactory (R.S.D. = 13.7% and 3.7% at the 0.5 and 5 nmol level, respectively).

U2 - 10.1016/S0021-9673(97)01083-2

DO - 10.1016/S0021-9673(97)01083-2

M3 - Article

SN - 0021-9673

VL - 799

SP - 57

EP - 66

JO - Journal of Chromatography A

JF - Journal of Chromatography A

ER -

Liquid chromatography with luminol- based electrochemiluminescence detection. Determination of histamine.

Abstract

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