Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age X SNP interaction and Cardiometabolic Disease Associations

R.P.S. Middelberg; B. Benyamin; M.H.M. de Moor; N.M. Warrington; S. Gordon; A.K. Henders; S.E. Medland; DR Nyholt; E.J.C. de Geus; J.J. Hottenga; G. Willemsen; L.J. Beilin; T.A. Mori; M.J. Wright; A.C. Heath; P.A.F. Madden; D.I. Boomsma; C.E. Pennell; G.W. Montgomery; N.G. Martin; J.B. Whitfield

doi:10.1093/hmg/ddr478

Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age X SNP interaction and Cardiometabolic Disease Associations

R.P.S. Middelberg, B. Benyamin, M.H.M. de Moor, N.M. Warrington, S. Gordon, A.K. Henders, S.E. Medland, DR Nyholt, E.J.C. de Geus, J.J. Hottenga, G. Willemsen, L.J. Beilin, T.A. Mori, M.J. Wright, A.C. Heath, P.A.F. Madden, D.I. Boomsma, C.E. Pennell, G.W. Montgomery, N.G. MartinJ.B. Whitfield

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers. We have discovered novel loci affecting GGT in a genome-wide association study (rs1497406 in an intergenic region of chromosome 1, P = 3.9 × 10

Original language	English
Pages (from-to)	446-455
Journal	Human Molecular Genetics
Volume	21
Issue number	2
DOIs	https://doi.org/10.1093/hmg/ddr478
Publication status	Published - 2012

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Netherlands Twin Register (NTR)

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Middelberg, R. P. S., Benyamin, B., de Moor, M. H. M., Warrington, N. M., Gordon, S., Henders, A. K., Medland, S. E., Nyholt, DR., de Geus, E. J. C., Hottenga, J. J., Willemsen, G., Beilin, L. J., Mori, T. A., Wright, M. J., Heath, A. C., Madden, P. A. F., Boomsma, D. I., Pennell, C. E., Montgomery, G. W., ... Whitfield, J. B. (2012). Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age X SNP interaction and Cardiometabolic Disease Associations. Human Molecular Genetics, 21(2), 446-455. https://doi.org/10.1093/hmg/ddr478

Middelberg, R.P.S. ; Benyamin, B. ; de Moor, M.H.M. ; Warrington, N.M. ; Gordon, S. ; Henders, A.K. ; Medland, S.E. ; Nyholt, DR ; de Geus, E.J.C. ; Hottenga, J.J. ; Willemsen, G. ; Beilin, L.J. ; Mori, T.A. ; Wright, M.J. ; Heath, A.C. ; Madden, P.A.F. ; Boomsma, D.I. ; Pennell, C.E. ; Montgomery, G.W. ; Martin, N.G. ; Whitfield, J.B. / Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age X SNP interaction and Cardiometabolic Disease Associations. In: Human Molecular Genetics. 2012 ; Vol. 21, No. 2. pp. 446-455.

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title = "Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age X SNP interaction and Cardiometabolic Disease Associations",

abstract = "Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers. We have discovered novel loci affecting GGT in a genome-wide association study (rs1497406 in an intergenic region of chromosome 1, P = 3.9 × 10",

author = "R.P.S. Middelberg and B. Benyamin and {de Moor}, M.H.M. and N.M. Warrington and S. Gordon and A.K. Henders and S.E. Medland and DR Nyholt and {de Geus}, E.J.C. and J.J. Hottenga and G. Willemsen and L.J. Beilin and T.A. Mori and M.J. Wright and A.C. Heath and P.A.F. Madden and D.I. Boomsma and C.E. Pennell and G.W. Montgomery and N.G. Martin and J.B. Whitfield",

year = "2012",

doi = "10.1093/hmg/ddr478",

language = "English",

volume = "21",

pages = "446--455",

journal = "Human Molecular Genetics",

issn = "0964-6906",

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Middelberg, RPS, Benyamin, B, de Moor, MHM, Warrington, NM, Gordon, S, Henders, AK, Medland, SE, Nyholt, DR, de Geus, EJC , Hottenga, JJ , Willemsen, G, Beilin, LJ, Mori, TA, Wright, MJ, Heath, AC, Madden, PAF, Boomsma, DI, Pennell, CE, Montgomery, GW, Martin, NG & Whitfield, JB 2012, 'Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age X SNP interaction and Cardiometabolic Disease Associations', Human Molecular Genetics, vol. 21, no. 2, pp. 446-455. https://doi.org/10.1093/hmg/ddr478

Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age X SNP interaction and Cardiometabolic Disease Associations. / Middelberg, R.P.S.; Benyamin, B.; de Moor, M.H.M.; Warrington, N.M.; Gordon, S.; Henders, A.K.; Medland, S.E.; Nyholt, DR; de Geus, E.J.C.; Hottenga, J.J.; Willemsen, G.; Beilin, L.J.; Mori, T.A.; Wright, M.J.; Heath, A.C.; Madden, P.A.F.; Boomsma, D.I.; Pennell, C.E.; Montgomery, G.W.; Martin, N.G.; Whitfield, J.B.

In: Human Molecular Genetics, Vol. 21, No. 2, 2012, p. 446-455.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age X SNP interaction and Cardiometabolic Disease Associations

AU - Middelberg, R.P.S.

AU - Benyamin, B.

AU - de Moor, M.H.M.

AU - Warrington, N.M.

AU - Gordon, S.

AU - Henders, A.K.

AU - Medland, S.E.

AU - Nyholt, DR

AU - de Geus, E.J.C.

AU - Hottenga, J.J.

AU - Willemsen, G.

AU - Beilin, L.J.

AU - Mori, T.A.

AU - Wright, M.J.

AU - Heath, A.C.

AU - Madden, P.A.F.

AU - Boomsma, D.I.

AU - Pennell, C.E.

AU - Montgomery, G.W.

AU - Martin, N.G.

AU - Whitfield, J.B.

PY - 2012

Y1 - 2012

N2 - Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers. We have discovered novel loci affecting GGT in a genome-wide association study (rs1497406 in an intergenic region of chromosome 1, P = 3.9 × 10

AB - Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers. We have discovered novel loci affecting GGT in a genome-wide association study (rs1497406 in an intergenic region of chromosome 1, P = 3.9 × 10

U2 - 10.1093/hmg/ddr478

DO - 10.1093/hmg/ddr478

M3 - Article

VL - 21

SP - 446

EP - 455

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 2

ER -

Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age X SNP interaction and Cardiometabolic Disease Associations

Abstract

Cohort Studies

UN SDGs

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