Loci Affecting Gamma-Glutamyl Transferase in Adults and Adolescents Show Age X SNP interaction and Cardiometabolic Disease Associations

R.P.S. Middelberg, B. Benyamin, M.H.M. de Moor, N.M. Warrington, S. Gordon, A.K. Henders, S.E. Medland, DR Nyholt, E.J.C. de Geus, J.J. Hottenga, G. Willemsen, L.J. Beilin, T.A. Mori, M.J. Wright, A.C. Heath, P.A.F. Madden, D.I. Boomsma, C.E. Pennell, G.W. Montgomery, N.G. MartinJ.B. Whitfield

Research output: Contribution to JournalArticleAcademicpeer-review


Serum gamma-glutamyl transferase (GGT) activity is a marker of liver disease which is also prospectively associated with the risk of all-cause mortality, cardiovascular disease, type 2 diabetes and cancers. We have discovered novel loci affecting GGT in a genome-wide association study (rs1497406 in an intergenic region of chromosome 1, P = 3.9 × 10
Original languageEnglish
Pages (from-to)446-455
JournalHuman Molecular Genetics
Issue number2
Publication statusPublished - 2012


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