Loci influencing blood pressure identified using a cardiovascular gene-centric array

S.K. Ganesh; V. Tragante; W. Guo; Y.R. Guo; M.B. Lanktree; E.N. Smith; T. Johnson; B.A. Castillo; J. Barnard; J. Baumert; Y.P.C. Chang; C.C. Elbers; M. Farrall; M.E. Fischer; N. Franceschini; T.R. Gaunt; J.M.I.H. Gho; C. Gieger; Y. Gong; A. Isaacs; M.E. Kleber; I.M. Leach; C.W. McDonough; M.F.L. Meijs; O. Mellander; C.M. Molony; I.M. Nolte; S. Padmanabhan; T.S. Price; R. Rajagopalan; J. Shaffer; S. Shah; H.Q. Shen; N. Soranzo; P.J. van der Most; E.P.A. van Iperen; J.A. Van Setten; J.M. Vonk; L. Zhang; A.L. Beitelshees; G.S. Berenson; D.L. Bhatt; J.M.A. Boer; E. Boerwinkle; B. Burkley; A. Burt; A. Chakravarti; W. Chen; R.M. Cooper-DeHoff; S.P. Curtis; A. Dreisbach; D. Duggan; G.B. Ehret; R.R. Fabsitz; M. Fornage; E. Fox; C.E. Furlong; R.T. Gansevoort; M.H. Hofker; G.K. Hovingh; S.A. Kirkland; K. Kottke-Marchant; A. Kutlar; A.Z. LaCroix; T.Y. Langaee; Y.R. Li; H.H. Lin; K. Liu; S. Maiwald; R. Malik; G. Murugesan; C. Newton-Cheh; J.R. OConnell; N.C. Onland-Moret; W.H. Ouwehand; W. Palmas; B.W.J.H. Penninx; C.J. Pepine; M. Pettinger; J.F. Polak; V.S. Ramachandran; J. Ranchalis; S. Redline; P.M. Ridker; L.M. Rose; H. Scharnag; N.J. Schork; D. Shimbo; A.R. Shuldiner; S.R. Srinivasan; R.P Stolk; H.A. Taylor; B. Thorand; M.D. Trip; C.M. van Duijn; W.M. Verschuren; C. Wijmenga; B.R. Winkelmann; S. Wyatt; B.J. Keating; F.W. Asselbergs

doi:10.1093/hmg/dds555

Loci influencing blood pressure identified using a cardiovascular gene-centric array

S.K. Ganesh, V. Tragante, W. Guo, Y.R. Guo, M.B. Lanktree, E.N. Smith, T. Johnson, B.A. Castillo, J. Barnard, J. Baumert, Y.P.C. Chang, C.C. Elbers, M. Farrall, M.E. Fischer, N. Franceschini, T.R. Gaunt, J.M.I.H. Gho, C. Gieger, Y. Gong, A. IsaacsM.E. Kleber, I.M. Leach, C.W. McDonough, M.F.L. Meijs, O. Mellander, C.M. Molony, I.M. Nolte, S. Padmanabhan, T.S. Price, R. Rajagopalan, J. Shaffer, S. Shah, H.Q. Shen, N. Soranzo, P.J. van der Most, E.P.A. van Iperen, J.A. Van Setten, J.M. Vonk, L. Zhang, A.L. Beitelshees, G.S. Berenson, D.L. Bhatt, J.M.A. Boer, E. Boerwinkle, B. Burkley, A. Burt, A. Chakravarti, W. Chen, R.M. Cooper-DeHoff, S.P. Curtis, A. Dreisbach, D. Duggan, G.B. Ehret, R.R. Fabsitz, M. Fornage, E. Fox, C.E. Furlong, R.T. Gansevoort, M.H. Hofker, G.K. Hovingh, S.A. Kirkland, K. Kottke-Marchant, A. Kutlar, A.Z. LaCroix, T.Y. Langaee, Y.R. Li, H.H. Lin, K. Liu, S. Maiwald, R. Malik, G. Murugesan, C. Newton-Cheh, J.R. OConnell, N.C. Onland-Moret, W.H. Ouwehand, W. Palmas, B.W.J.H. Penninx, C.J. Pepine, M. Pettinger, J.F. Polak, V.S. Ramachandran, J. Ranchalis, S. Redline, P.M. Ridker, L.M. Rose, H. Scharnag, N.J. Schork, D. Shimbo, A.R. Shuldiner, S.R. Srinivasan, R.P Stolk, H.A. Taylor, B. Thorand, M.D. Trip, C.M. van Duijn, W.M. Verschuren, C. Wijmenga, B.R. Winkelmann, S. Wyatt, B.J. Keating, F.W. Asselbergs

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped ~50 000 single-nucleotide polymorphisms (SNPs) that capture variation in ~2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P < 2.4 × 10

Original language	English
Pages (from-to)	1663-1678
Journal	Human Molecular Genetics
Volume	22
Issue number	8
DOIs	https://doi.org/10.1093/hmg/dds555
Publication status	Published - 2013

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Ganesh, S. K., Tragante, V., Guo, W., Guo, Y. R., Lanktree, M. B., Smith, E. N., Johnson, T., Castillo, B. A., Barnard, J., Baumert, J., Chang, Y. P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Franceschini, N., Gaunt, T. R., Gho, J. M. I. H., Gieger, C., Gong, Y., ... Asselbergs, F. W. (2013). Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics, 22(8), 1663-1678. https://doi.org/10.1093/hmg/dds555

@article{2e18d1ca08c845de92c3567a47288989,

title = "Loci influencing blood pressure identified using a cardiovascular gene-centric array",

abstract = "Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped ~50 000 single-nucleotide polymorphisms (SNPs) that capture variation in ~2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P < 2.4 × 10",

author = "S.K. Ganesh and V. Tragante and W. Guo and Y.R. Guo and M.B. Lanktree and E.N. Smith and T. Johnson and B.A. Castillo and J. Barnard and J. Baumert and Y.P.C. Chang and C.C. Elbers and M. Farrall and M.E. Fischer and N. Franceschini and T.R. Gaunt and J.M.I.H. Gho and C. Gieger and Y. Gong and A. Isaacs and M.E. Kleber and I.M. Leach and C.W. McDonough and M.F.L. Meijs and O. Mellander and C.M. Molony and I.M. Nolte and S. Padmanabhan and T.S. Price and R. Rajagopalan and J. Shaffer and S. Shah and H.Q. Shen and N. Soranzo and {van der Most}, P.J. and {van Iperen}, E.P.A. and {Van Setten}, J.A. and J.M. Vonk and L. Zhang and A.L. Beitelshees and G.S. Berenson and D.L. Bhatt and J.M.A. Boer and E. Boerwinkle and B. Burkley and A. Burt and A. Chakravarti and W. Chen and R.M. Cooper-DeHoff and S.P. Curtis and A. Dreisbach and D. Duggan and G.B. Ehret and R.R. Fabsitz and M. Fornage and E. Fox and C.E. Furlong and R.T. Gansevoort and M.H. Hofker and G.K. Hovingh and S.A. Kirkland and K. Kottke-Marchant and A. Kutlar and A.Z. LaCroix and T.Y. Langaee and Y.R. Li and H.H. Lin and K. Liu and S. Maiwald and R. Malik and G. Murugesan and C. Newton-Cheh and J.R. OConnell and N.C. Onland-Moret and W.H. Ouwehand and W. Palmas and B.W.J.H. Penninx and C.J. Pepine and M. Pettinger and J.F. Polak and V.S. Ramachandran and J. Ranchalis and S. Redline and P.M. Ridker and L.M. Rose and H. Scharnag and N.J. Schork and D. Shimbo and A.R. Shuldiner and S.R. Srinivasan and R.P Stolk and H.A. Taylor and B. Thorand and M.D. Trip and {van Duijn}, C.M. and W.M. Verschuren and C. Wijmenga and B.R. Winkelmann and S. Wyatt and B.J. Keating and F.W. Asselbergs",

year = "2013",

doi = "10.1093/hmg/dds555",

language = "English",

volume = "22",

pages = "1663--1678",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "8",

}

Ganesh, SK, Tragante, V, Guo, W, Guo, YR, Lanktree, MB, Smith, EN, Johnson, T, Castillo, BA, Barnard, J, Baumert, J, Chang, YPC, Elbers, CC, Farrall, M, Fischer, ME, Franceschini, N, Gaunt, TR, Gho, JMIH, Gieger, C, Gong, Y, Isaacs, A, Kleber, ME, Leach, IM, McDonough, CW, Meijs, MFL, Mellander, O, Molony, CM, Nolte, IM, Padmanabhan, S, Price, TS, Rajagopalan, R, Shaffer, J, Shah, S, Shen, HQ, Soranzo, N, van der Most, PJ, van Iperen, EPA, Van Setten, JA, Vonk, JM, Zhang, L, Beitelshees, AL, Berenson, GS, Bhatt, DL, Boer, JMA, Boerwinkle, E, Burkley, B, Burt, A, Chakravarti, A, Chen, W, Cooper-DeHoff, RM, Curtis, SP, Dreisbach, A, Duggan, D, Ehret, GB, Fabsitz, RR, Fornage, M, Fox, E, Furlong, CE, Gansevoort, RT, Hofker, MH, Hovingh, GK, Kirkland, SA, Kottke-Marchant, K, Kutlar, A, LaCroix, AZ, Langaee, TY, Li, YR, Lin, HH, Liu, K, Maiwald, S, Malik, R, Murugesan, G, Newton-Cheh, C, OConnell, JR, Onland-Moret, NC, Ouwehand, WH, Palmas, W, Penninx, BWJH, Pepine, CJ, Pettinger, M, Polak, JF, Ramachandran, VS, Ranchalis, J, Redline, S, Ridker, PM, Rose, LM, Scharnag, H, Schork, NJ, Shimbo, D, Shuldiner, AR, Srinivasan, SR, Stolk, RP, Taylor, HA, Thorand, B, Trip, MD, van Duijn, CM, Verschuren, WM, Wijmenga, C, Winkelmann, BR, Wyatt, S, Keating, BJ & Asselbergs, FW 2013, 'Loci influencing blood pressure identified using a cardiovascular gene-centric array', Human Molecular Genetics, vol. 22, no. 8, pp. 1663-1678. https://doi.org/10.1093/hmg/dds555

TY - JOUR

T1 - Loci influencing blood pressure identified using a cardiovascular gene-centric array

AU - Ganesh, S.K.

AU - Tragante, V.

AU - Guo, W.

AU - Guo, Y.R.

AU - Lanktree, M.B.

AU - Smith, E.N.

AU - Johnson, T.

AU - Castillo, B.A.

AU - Barnard, J.

AU - Baumert, J.

AU - Chang, Y.P.C.

AU - Elbers, C.C.

AU - Farrall, M.

AU - Fischer, M.E.

AU - Franceschini, N.

AU - Gaunt, T.R.

AU - Gho, J.M.I.H.

AU - Gieger, C.

AU - Gong, Y.

AU - Isaacs, A.

AU - Kleber, M.E.

AU - Leach, I.M.

AU - McDonough, C.W.

AU - Meijs, M.F.L.

AU - Mellander, O.

AU - Molony, C.M.

AU - Nolte, I.M.

AU - Padmanabhan, S.

AU - Price, T.S.

AU - Rajagopalan, R.

AU - Shaffer, J.

AU - Shah, S.

AU - Shen, H.Q.

AU - Soranzo, N.

AU - van der Most, P.J.

AU - van Iperen, E.P.A.

AU - Van Setten, J.A.

AU - Vonk, J.M.

AU - Zhang, L.

AU - Beitelshees, A.L.

AU - Berenson, G.S.

AU - Bhatt, D.L.

AU - Boer, J.M.A.

AU - Boerwinkle, E.

AU - Burkley, B.

AU - Burt, A.

AU - Chakravarti, A.

AU - Chen, W.

AU - Cooper-DeHoff, R.M.

AU - Curtis, S.P.

AU - Dreisbach, A.

AU - Duggan, D.

AU - Ehret, G.B.

AU - Fabsitz, R.R.

AU - Fornage, M.

AU - Fox, E.

AU - Furlong, C.E.

AU - Gansevoort, R.T.

AU - Hofker, M.H.

AU - Hovingh, G.K.

AU - Kirkland, S.A.

AU - Kottke-Marchant, K.

AU - Kutlar, A.

AU - LaCroix, A.Z.

AU - Langaee, T.Y.

AU - Li, Y.R.

AU - Lin, H.H.

AU - Liu, K.

AU - Maiwald, S.

AU - Malik, R.

AU - Murugesan, G.

AU - Newton-Cheh, C.

AU - OConnell, J.R.

AU - Onland-Moret, N.C.

AU - Ouwehand, W.H.

AU - Palmas, W.

AU - Penninx, B.W.J.H.

AU - Pepine, C.J.

AU - Pettinger, M.

AU - Polak, J.F.

AU - Ramachandran, V.S.

AU - Ranchalis, J.

AU - Redline, S.

AU - Ridker, P.M.

AU - Rose, L.M.

AU - Scharnag, H.

AU - Schork, N.J.

AU - Shimbo, D.

AU - Shuldiner, A.R.

AU - Srinivasan, S.R.

AU - Stolk, R.P

AU - Taylor, H.A.

AU - Thorand, B.

AU - Trip, M.D.

AU - van Duijn, C.M.

AU - Verschuren, W.M.

AU - Wijmenga, C.

AU - Winkelmann, B.R.

AU - Wyatt, S.

AU - Keating, B.J.

AU - Asselbergs, F.W.

PY - 2013

Y1 - 2013

N2 - Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped ~50 000 single-nucleotide polymorphisms (SNPs) that capture variation in ~2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P < 2.4 × 10

AB - Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped ~50 000 single-nucleotide polymorphisms (SNPs) that capture variation in ~2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P < 2.4 × 10

U2 - 10.1093/hmg/dds555

DO - 10.1093/hmg/dds555

M3 - Article

SN - 0964-6906

VL - 22

SP - 1663

EP - 1678

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 8

ER -

Loci influencing blood pressure identified using a cardiovascular gene-centric array

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