Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

Y.S. Aulchenko, S. Ripatti, I. Lindqvist, D.I. Boomsma, I.M. Heid, P.P. Pramstaller, B.W.J.H. Penninx, A.C.J.W. Janssen, J.F. Wilson, T. Spector, N.G. Martin, N.L. Pedersen, K.O. Kyvik, J. Kaprio, A. Hofman, N.B. Freimer, M.-R. Jarvelin, U. Gyllensten, H. Campbell, I. RudanA. Johansson, F. Marroni, C. Hayward, V. Vitart, I. Jonasson, C. Pattar, A. Wright, N. Hastie, I. Pichler, A.A. Hicks, M. Falchi, G. Willemsen, J.J. Hottenga, E.J.C. de Geus, GW Montgomery, J. Whitfield, P. Magnusson, J. Saharinen, M. Perola, K. Silander, A. Isaacs, E.J.G. Sijbrands, A.G. Uitterlinden, J.C.M. Witteman, B.A. Oostra, P. Elliott, A. Ruokonen, C. Sabatti, C. Gieger, T. Meitinger, F. Kronenberg, A. Döring, H.-E. Wichmann, J.H. Smit, M.I. McCarthy, C.M. van Duijn, L. Peltonen

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Abstract

Recent genome-wide association (GWA) studies of lipids have been conducted in samples ascertained for other phenotypes, particularly diabetes. Here we report the first GWA analysis of loci affecting total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides sampled randomly from 16 population-based cohorts and genotyped using mainly the Illumina HumanHap300-Duo platform. Our study included a total of 17,797-22,562 persons, aged 18-104 years and from geographic regions spanning from the Nordic countries to Southern Europe. We established 22 loci associated with serum lipid levels at a genome-wide significance level (P < 5 × 10
Original languageEnglish
Pages (from-to)47-55
JournalNature Genetics
Volume41
Issue number1
DOIs
Publication statusPublished - 2009

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