Long-term outcomes of acute treatment with cognitive therapy v. Interpersonal psychotherapy for adult depression: Follow-up of a randomized controlled trial

Lotte H.J.M. Lemmens, Suzanne C. Van Bronswijk, Frenk Peeters, Arnoud Arntz, Steven D. Hollon, Marcus J.H. Huibers

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Abstract

Background Although equally efficacious in the acute phase, it is not known how cognitive therapy (CT) and interpersonal psychotherapy (IPT) for major depressive disorder (MDD) compare in the long run. This study examined the long-term outcomes of CT v. IPT for MDD.Methods One hundred thirty-four adult (18-65) depressed outpatients who were treated with CT (n = 69) or IPT (n = 65) in a large open-label randomized controlled trial (parallel group design; computer-generated block randomization) were monitored across a 17-month follow-up phase. Mixed regression was used to determine the course of self-reported depressive symptom severity (Beck Depression Inventory II; BDI-II) after treatment termination, and to test whether CT and IPT differed throughout the follow-up phase. Analyses were conducted for the total sample (n = 134) and for the subsample of treatment responders (n = 85). Furthermore, for treatment responders, rates of relapse and sustained response were examined for self-reported (BDI-II) and clinician-rated (Longitudinal Interval Follow-up Evaluation; LIFE) depression using Cox regression.Results On average, the symptom reduction achieved during the 7-month treatment phase was maintained across follow-up (7-24 months) for CT and IPT, both in the total sample and in the responder sample. Two-thirds (67%) of the treatment responders did not relapse across the follow-up period on the BDI-II. Relapse rates assessed with the LIFE were somewhat lower. No differential effects between conditions were found.Conclusions Patients who responded to IPT were no more likely to relapse following treatment termination than patients who responded to CT. Given that CT appears to have a prophylactic effect following successful treatment, our findings suggest that IPT might have a prophylactic effect as well.

Original languageEnglish
Pages (from-to)465-473
Number of pages9
JournalPsychological Medicine
Volume49
Issue number3
Early online date24 May 2018
DOIs
Publication statusPublished - Feb 2019

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Cognitive Therapy
Psychotherapy
Randomized Controlled Trials
Depression
Recurrence
Major Depressive Disorder
Therapeutics
Random Allocation
Outpatients
Equipment and Supplies

Keywords

  • Cognitive therapy
  • interpersonal psychotherapy
  • long-term outcomes
  • major depression
  • outcome studies
  • relapse
  • sustained response.

Cite this

Lemmens, Lotte H.J.M. ; Van Bronswijk, Suzanne C. ; Peeters, Frenk ; Arntz, Arnoud ; Hollon, Steven D. ; Huibers, Marcus J.H. / Long-term outcomes of acute treatment with cognitive therapy v. Interpersonal psychotherapy for adult depression : Follow-up of a randomized controlled trial. In: Psychological Medicine. 2019 ; Vol. 49, No. 3. pp. 465-473.
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Long-term outcomes of acute treatment with cognitive therapy v. Interpersonal psychotherapy for adult depression : Follow-up of a randomized controlled trial. / Lemmens, Lotte H.J.M.; Van Bronswijk, Suzanne C.; Peeters, Frenk; Arntz, Arnoud; Hollon, Steven D.; Huibers, Marcus J.H.

In: Psychological Medicine, Vol. 49, No. 3, 02.2019, p. 465-473.

Research output: Contribution to JournalArticleAcademicpeer-review

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T1 - Long-term outcomes of acute treatment with cognitive therapy v. Interpersonal psychotherapy for adult depression

T2 - Follow-up of a randomized controlled trial

AU - Lemmens, Lotte H.J.M.

AU - Van Bronswijk, Suzanne C.

AU - Peeters, Frenk

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AU - Hollon, Steven D.

AU - Huibers, Marcus J.H.

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AB - Background Although equally efficacious in the acute phase, it is not known how cognitive therapy (CT) and interpersonal psychotherapy (IPT) for major depressive disorder (MDD) compare in the long run. This study examined the long-term outcomes of CT v. IPT for MDD.Methods One hundred thirty-four adult (18-65) depressed outpatients who were treated with CT (n = 69) or IPT (n = 65) in a large open-label randomized controlled trial (parallel group design; computer-generated block randomization) were monitored across a 17-month follow-up phase. Mixed regression was used to determine the course of self-reported depressive symptom severity (Beck Depression Inventory II; BDI-II) after treatment termination, and to test whether CT and IPT differed throughout the follow-up phase. Analyses were conducted for the total sample (n = 134) and for the subsample of treatment responders (n = 85). Furthermore, for treatment responders, rates of relapse and sustained response were examined for self-reported (BDI-II) and clinician-rated (Longitudinal Interval Follow-up Evaluation; LIFE) depression using Cox regression.Results On average, the symptom reduction achieved during the 7-month treatment phase was maintained across follow-up (7-24 months) for CT and IPT, both in the total sample and in the responder sample. Two-thirds (67%) of the treatment responders did not relapse across the follow-up period on the BDI-II. Relapse rates assessed with the LIFE were somewhat lower. No differential effects between conditions were found.Conclusions Patients who responded to IPT were no more likely to relapse following treatment termination than patients who responded to CT. Given that CT appears to have a prophylactic effect following successful treatment, our findings suggest that IPT might have a prophylactic effect as well.

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