Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update

Rebecca T. Karsten; Lisette van der Molen; Olga Hamming-Vrieze; Rob J.J.H. van Son; Frans J.M. Hilgers; Michiel W.M. van den Brekel; Martijn M. Stuiver; Ludi E. Smeele

doi:10.1002/hed.26120

Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update

Rebecca T. Karsten, Lisette van der Molen, Olga Hamming-Vrieze, Rob J.J.H. van Son, Frans J.M. Hilgers, Michiel W.M. van den Brekel, Martijn M. Stuiver, Ludi E. Smeele

Maxillofacial Surgery (AMC)

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: The objective of this study was to explore the 10-year plus outcomes of Intensity Modulated Radiotherapy with concomitant chemotherapy (CRT) combined with preventive swallowing rehabilitation (CRT+) for head and neck cancer (HNC). Methods: Subjective and objective swallowing, trismus, and speech related outcomes were assessed at 10-year plus after CRT+. Outcomes were compared to previously published 6-year results of the same cohort. Results: Fourteen of the 22 patients at 6-year follow-up were evaluable. Although objective swallowing-related outcomes showed no deterioration (eg, no feeding tube dependency and no pneumonia), swallowing-related quality of life slightly deteriorated over time. No patients had or perceived trismus. Voice and speech questionnaires showed little problems in daily life. Overall quality of life (QOL) was good. Conclusions: After CRT with preventive rehabilitation exercises for advanced HNC, swallowing, trismus, and speech related outcomes moderately deteriorated from 6 to 10 years, with an on average good overall QOL after.

Original language	English
Pages (from-to)	1907-1918
Journal	Head and Neck
Volume	42
Issue number	8
Early online date	29 Feb 2020
DOIs	https://doi.org/10.1002/hed.26120
Publication status	Published - Aug 2020

Funding

Catherine Middag from the imec-IDLAB in Gent is greatly acknowledged for performing the speech analyses in ASISTO. The NKI-AVL receives a research grant from ATOS Medical Sweden, which contributes to the existing infrastructure for health-related, quality-of-life research in the Department of Head and Neck Oncology and Surgery.

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Atos

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Karsten, R. T., van der Molen, L., Hamming-Vrieze, O., van Son, R. J. J. H., Hilgers, F. J. M., van den Brekel, M. W. M., Stuiver, M. M., & Smeele, L. E. (2020). Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update. Head and Neck, 42(8), 1907-1918. https://doi.org/10.1002/hed.26120

@article{bf849cda35b74664a28f7a14398dcd8b,

title = "Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update",

abstract = "Background: The objective of this study was to explore the 10-year plus outcomes of Intensity Modulated Radiotherapy with concomitant chemotherapy (CRT) combined with preventive swallowing rehabilitation (CRT+) for head and neck cancer (HNC). Methods: Subjective and objective swallowing, trismus, and speech related outcomes were assessed at 10-year plus after CRT+. Outcomes were compared to previously published 6-year results of the same cohort. Results: Fourteen of the 22 patients at 6-year follow-up were evaluable. Although objective swallowing-related outcomes showed no deterioration (eg, no feeding tube dependency and no pneumonia), swallowing-related quality of life slightly deteriorated over time. No patients had or perceived trismus. Voice and speech questionnaires showed little problems in daily life. Overall quality of life (QOL) was good. Conclusions: After CRT with preventive rehabilitation exercises for advanced HNC, swallowing, trismus, and speech related outcomes moderately deteriorated from 6 to 10 years, with an on average good overall QOL after.",

author = "Karsten, {Rebecca T.} and {van der Molen}, Lisette and Olga Hamming-Vrieze and {van Son}, {Rob J.J.H.} and Hilgers, {Frans J.M.} and {van den Brekel}, {Michiel W.M.} and Stuiver, {Martijn M.} and Smeele, {Ludi E.}",

year = "2020",

month = aug,

doi = "10.1002/hed.26120",

language = "English",

volume = "42",

pages = "1907--1918",

journal = "Head and Neck",

issn = "1043-3074",

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Karsten, RT, van der Molen, L, Hamming-Vrieze, O, van Son, RJJH, Hilgers, FJM, van den Brekel, MWM, Stuiver, MM & Smeele, LE 2020, 'Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update', Head and Neck, vol. 42, no. 8, pp. 1907-1918. https://doi.org/10.1002/hed.26120

Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update. / Karsten, Rebecca T.; van der Molen, Lisette; Hamming-Vrieze, Olga et al.
In: Head and Neck, Vol. 42, No. 8, 08.2020, p. 1907-1918.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update

AU - Karsten, Rebecca T.

AU - van der Molen, Lisette

AU - Hamming-Vrieze, Olga

AU - van Son, Rob J.J.H.

AU - Hilgers, Frans J.M.

AU - van den Brekel, Michiel W.M.

AU - Stuiver, Martijn M.

AU - Smeele, Ludi E.

PY - 2020/8

Y1 - 2020/8

N2 - Background: The objective of this study was to explore the 10-year plus outcomes of Intensity Modulated Radiotherapy with concomitant chemotherapy (CRT) combined with preventive swallowing rehabilitation (CRT+) for head and neck cancer (HNC). Methods: Subjective and objective swallowing, trismus, and speech related outcomes were assessed at 10-year plus after CRT+. Outcomes were compared to previously published 6-year results of the same cohort. Results: Fourteen of the 22 patients at 6-year follow-up were evaluable. Although objective swallowing-related outcomes showed no deterioration (eg, no feeding tube dependency and no pneumonia), swallowing-related quality of life slightly deteriorated over time. No patients had or perceived trismus. Voice and speech questionnaires showed little problems in daily life. Overall quality of life (QOL) was good. Conclusions: After CRT with preventive rehabilitation exercises for advanced HNC, swallowing, trismus, and speech related outcomes moderately deteriorated from 6 to 10 years, with an on average good overall QOL after.

AB - Background: The objective of this study was to explore the 10-year plus outcomes of Intensity Modulated Radiotherapy with concomitant chemotherapy (CRT) combined with preventive swallowing rehabilitation (CRT+) for head and neck cancer (HNC). Methods: Subjective and objective swallowing, trismus, and speech related outcomes were assessed at 10-year plus after CRT+. Outcomes were compared to previously published 6-year results of the same cohort. Results: Fourteen of the 22 patients at 6-year follow-up were evaluable. Although objective swallowing-related outcomes showed no deterioration (eg, no feeding tube dependency and no pneumonia), swallowing-related quality of life slightly deteriorated over time. No patients had or perceived trismus. Voice and speech questionnaires showed little problems in daily life. Overall quality of life (QOL) was good. Conclusions: After CRT with preventive rehabilitation exercises for advanced HNC, swallowing, trismus, and speech related outcomes moderately deteriorated from 6 to 10 years, with an on average good overall QOL after.

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DO - 10.1002/hed.26120

M3 - Article

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SN - 1043-3074

VL - 42

SP - 1907

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JO - Head and Neck

JF - Head and Neck

IS - 8

ER -

Long-term swallowing, trismus, and speech outcomes after combined chemoradiotherapy and preventive rehabilitation for head and neck cancer; 10-year plus update

Abstract

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UN SDGs

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