Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Yu-Xuan Lyu; Qiang Fu; Dominika Wilczok; Kejun Ying; Aaron King; Adam Antebi; Aleksandar Vojta; Alexandra Stolzing; Alexey Moskalev; Anastasia Georgievskaya; Andrea B Maier; Andrea Olsen; Anja Groth; Anna Katharina Simon; Anne Brunet; Aisyah Jamil; Anton Kulaga; Asif Bhatti; Benjamin Yaden; Bente Klarlund Pedersen; Björn Schumacher; Boris Djordjevic; Brian Kennedy; Chieh Chen; Christine Yuan Huang; Christoph U Correll; Coleen T Murphy; Collin Y Ewald; Danica Chen; Dario Riccardo Valenzano; Dariusz Sołdacki; David Erritzoe; David Meyer; David A Sinclair; Eduardo Nunes Chini; Emma C Teeling; Eric Morgen; Eric Verdin; Erik Vernet; Estefano Pinilla; Evandro F Fang; Evelyne Bischof; Evi M Mercken; Fabian Finger; Folkert Kuipers; Frank W Pun; Gabor Gyülveszi; Gabriele Civiletto; Garri Zmudze; Gil Blander; Harold A Pincus; Joshua McClure; James L Kirkland; James Peyer; Jamie N Justice; Jan Vijg; Jennifer R Gruhn; Jerry McLaughlin; Joan Mannick; João Passos; Joseph A Baur; Joe Betts-LaCroix; John M Sedivy; John R Speakman; Jordan Shlain; Julia von Maltzahn; Katrin I Andreasson; Kelsey Moody; Konstantinos Palikaras; Kristen Fortney; Laura J Niedernhofer; Lene Juel Rasmussen; Liesbeth M Veenhoff; Lisa Melton; Luigi Ferrucci; Marco Quarta; Maria Koval; Maria Marinova; Mark Hamalainen; Maximilian Unfried; Michael S Ringel; Milos Filipovic; Mourad Topors; Natalia Mitin; Nawal Roy; Nika Pintar; Nir Barzilai; Paolo Binetti; Parminder Singh; Paul Kohlhaas; Paul D Robbins; Paul Rubin; Peter O Fedichev; Petrina Kamya; Pura Muñoz-Canoves; Rafael de Cabo; Richard G A Faragher; Rob Konrad; Roberto Ripa; Robin Mansukhani; Sabrina Büttner; Sara A Wickström; Sebastian Brunemeier; Sergey Jakimov; Shan Luo; Sharon Rosenzweig-Lipson; Shih-Yin Tsai; Stefanie Dimmeler; Thomas A Rando; Tim R Peterson; Tina Woods; Tony Wyss-Coray; Toren Finkel; Tzipora Strauss; Vadim N Gladyshev; Valter D Longo; Varun B Dwaraka; Vera Gorbunova; Victoria A Acosta-Rodríguez; Vincenzo Sorrentino; Vittorio Sebastiano; Wenbin Li; Yousin Suh; Alex Zhavoronkov; Morten Scheibye-Knudsen; Daniela Bakula

doi:10.18632/aging.206135

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

Yu-Xuan Lyu, Qiang Fu, Dominika Wilczok, Kejun Ying, Aaron King, Adam Antebi, Aleksandar Vojta, Alexandra Stolzing, Alexey Moskalev, Anastasia Georgievskaya, Andrea B Maier, Andrea Olsen, Anja Groth, Anna Katharina Simon, Anne Brunet, Aisyah Jamil, Anton Kulaga, Asif Bhatti, Benjamin Yaden, Bente Klarlund PedersenBjörn Schumacher, Boris Djordjevic, Brian Kennedy, Chieh Chen, Christine Yuan Huang, Christoph U Correll, Coleen T Murphy, Collin Y Ewald, Danica Chen, Dario Riccardo Valenzano, Dariusz Sołdacki, David Erritzoe, David Meyer, David A Sinclair, Eduardo Nunes Chini, Emma C Teeling, Eric Morgen, Eric Verdin, Erik Vernet, Estefano Pinilla, Evandro F Fang, Evelyne Bischof, Evi M Mercken, Fabian Finger, Folkert Kuipers, Frank W Pun, Gabor Gyülveszi, Gabriele Civiletto, Garri Zmudze, Gil Blander, Harold A Pincus, Joshua McClure, James L Kirkland, James Peyer, Jamie N Justice, Jan Vijg, Jennifer R Gruhn, Jerry McLaughlin, Joan Mannick, João Passos, Joseph A Baur, Joe Betts-LaCroix, John M Sedivy, John R Speakman, Jordan Shlain, Julia von Maltzahn, Katrin I Andreasson, Kelsey Moody, Konstantinos Palikaras, Kristen Fortney, Laura J Niedernhofer, Lene Juel Rasmussen, Liesbeth M Veenhoff, Lisa Melton, Luigi Ferrucci, Marco Quarta, Maria Koval, Maria Marinova, Mark Hamalainen, Maximilian Unfried, Michael S Ringel, Milos Filipovic, Mourad Topors, Natalia Mitin, Nawal Roy, Nika Pintar, Nir Barzilai, Paolo Binetti, Parminder Singh, Paul Kohlhaas, Paul D Robbins, Paul Rubin, Peter O Fedichev, Petrina Kamya, Pura Muñoz-Canoves, Rafael de Cabo, Richard G A Faragher, Rob Konrad, Roberto Ripa, Robin Mansukhani, Sabrina Büttner, Sara A Wickström, Sebastian Brunemeier, Sergey Jakimov, Shan Luo, Sharon Rosenzweig-Lipson, Shih-Yin Tsai, Stefanie Dimmeler, Thomas A Rando, Tim R Peterson, Tina Woods, Tony Wyss-Coray, Toren Finkel, Tzipora Strauss, Vadim N Gladyshev, Valter D Longo, Varun B Dwaraka, Vera Gorbunova, Victoria A Acosta-Rodríguez, Vincenzo Sorrentino, Vittorio Sebastiano, Wenbin Li, Yousin Suh, Alex Zhavoronkov, Morten Scheibye-Knudsen, Daniela Bakula

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

Original language	English
Pages (from-to)	12955-12976
Number of pages	22
Journal	Aging
Volume	16
Issue number	20
DOIs	https://doi.org/10.18632/aging.206135
Publication status	Published - 16 Oct 2024

Funding

South Wales, Sydney, New South Wales, Australia 87Longevity Biotech Fellowship, Longevity Acceleration Fund, Vitalism, SF Bay, CA 94101, USA 88Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117608, Singapore 89Boston Consulting Group, Boston, MA 02210, USA 90Leibniz-Institut F\u00FCr Analytische Wissenschaften-ISAS-E.V., Dortmund, Germany 91Repair Biotechnologies, Inc., Syracuse, NY 13210, USA 92Sapere Bio, Triangle Research Park, NC 27213, USA 93Holmusk, New York, NY 10012, USA 94AniBiome, Zagreb, Croatia 95Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10452, USA 96Molecule, Neuhausen am Rheinfall, Switzerland 97Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology, and Biochemistry, University of Minnesota, Minneapolis, MN 55111, USA 98Gero PTE, Singapore, Singapore 99Insilico Medicine Canada Inc., Montreal, Quebec H3B 4W8, Canada 100Altos Labs Inc., San Diego Institute of Science, San Diego, CA 92121, USA 101Translational Gerontology Branch, Intramural Research Program, National Institute on Aging (NIH), Baltimore, MD 21201, USA 102Huxley Building, School of Applied Sciences, University of Brighton, Brighton, UK 103Biolytica, Zug, Switzerland 104Deciduous Therapeutics, San Francisco, CA 94107, USA 105Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm 10691, Sweden 106Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, M\u00FCnster, Germany 107Healthspan Capital, El Cerrito, CA 94530, USA 108School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 109Department of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 110Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Germany 111Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA 112Bioio, Inc., St. Louis, MO 63110, USA 113Collider Heath, London, UK 114Healthy Longevity Champion, National Innovation Centre for Ageing, UK 115Aging Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15106, USA 116Sheba Longevity Center, Sheba Medical Center, Tel Hashomer, Israel 117Tel Aviv Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 118Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90001, USA 119TruDiagnostic, Lexington, KY 40503, USA 120Department of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA 121Department?of?Neuroscience,?Peter?O\u2019Donnell?Jr.?Brain?Institute,?University?of?Texas?Southwestern?Medical? A.K.S. supported by grants from the Wellcome Trust (Investigator award 220784/Z/20/Z). B.K.P The Centre for Physical Activity Research (CFAS) is supported by TrygFonden (grants ID 101390, ID 20045, and ID 125132). C.C. was supported by the Oppenheimer Program, UCLA Jonsson Cancer Center Foundation, Margaret E. Early Medical Research Trust, and National Center for Advancing Translational Sciences UCLA Clinical and Translational Science Institute (CTSI) Grant UL1TR000124. D.C. was supported by NIH R01AG082105, R01DK 117481, R01AG063404, and R01AG 063389. E.C.T. was supported by an Irish Research Council Laureate Award IRCLA/2017/58 and Science Foundation Ireland Future Frontiers 19/FFP/6790. J.V. is funded by grants from the US National Institutes of Health (grants U19AG056278, U01HL145560, U01ES029519, P01AG017242, P01AG047200). J.P. would like to acknowledge NIH grants R01AG068048, R01AG82708, UG3CA268103, and P01 AG062413. J.L.K. is supported by the National Institutes of Health (grants R37AG013925 and R33AG061456), the Connor Fund, the Robert J. and Theresa W. Ryan Fund, and the Noaber Foundation. K.M. was supported by NEI of the National Institutes of Health no. 1R43EY034403-01. L.J.N. and P.D.R. are supported by NIH (R01AG063543, U19AG056278, U54AG076041, U54AG079754). M.H. is funded by Longevity Biotech Fellowship. M.Q. from Rubedo Life Sciences received award from California Institute of Regenerative Medicine (CIRM #DISC-14096) for its pharmacological program on targeting senescent lung stem cells in Idiopathic Pulmonary Fibrosis. P.M. is funded from grant number ERC-2016AdG-741966. Q.F. received a grant from the Shandong Provincial Natural Science Foundation (ZR2023MH262), Yantai Double Hundred Program, University and Locality Collaborative Program (2021XDHZ082). S.L. was supported by the Healthy Longevity Catalyst Awards (Hong Kong): National Academy of Medicine, USA. T.A.R. is supported by grants from NIH AG68667 and AG82764. V.G. is supported by grants from the US National Institute on Aging, Impetus grants, Michael Antonov Foundation. V.S. research is supported by the NUHS Internal Grant Funding under NUS Start-up grant NUHSRO/2022/047/Startup/11. Y-X.L. is supported by grants from the Southern University of Science and Technology, China, and from the Max Planck Society, Germany. A.G. is affiliated with Haut.AI. A.K.S. is consulting for The Longevity Lab and Primeadine. D.S. is an employee of the Longevity Center Group. J.L.K. has a financial interest related to this research, including patents and pending patents covering senolytic drugs and their uses that are held by Mayo Clinic. This research has been reviewed by the Mayo Clinic Conflict of Interest Review Board and was conducted in compliance with Mayo Clinic conflict of interest policies. G.B. is an InsideTracker employee, and InsideTracker is the sole funder of Dr. Blander. G.C is the employee of DSM-Firmenich (Kaiseraugst, Switzerland). J.H. is a founder and scientific advisory board member of LongLifeRx and Aiance. J.S. is affiliated with Private Medical. J.V. is a co-founder of Singulomics Inc. and Mutagentech Inc. K.J.M. holds equity in Lysoclear, Inc. which is commercializing the presented technology. K.P. is funded by the Fondation Sant\u00E9 (19656) and the European Union (European Research Council; ERC), under grant agreement \u201CERC-GA101077374-SynaptoMitophagy\u201D. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Council. Neither the European Union nor the granting authority can be held responsible for them. M.H. is affiliated with Synthego, Frontier Bio, Ligandal, Longshot Space. M.S-K. is supported by the Novo Nordisk Foundation Challenge Programme (NNF17OC0027812), the Nordea Foundation (02-2017-1749), the Neye Foundation, the Lundbeck Foundation (R324-2019-1492), the Ministry of Higher Education and Science (0238-00003B), VitaDAO and Insilico Medicine. M.Q. is a founder and shareholder of Rubedo Life Sciences and Turn Biotechnologies. P.K., F.W.P., A.J. and A.Z. are employed at Insilico Medicine. P.M. was employed at Pompeu Fabra University and is currently employed at Altos Labs. T.F. is a co-founder and equity holder of Generian Pharmaceuticals and Coloma Therapeutics. A.K.S. supported by grants from the Wellcome Trust (Investigator award 220784/Z/20/Z). B.K.P The Centre for Physical Activity Research (CFAS) is supported by TrygFonden (grants ID 101390, ID 20045, and ID 125132). C.C. was supported by the Oppenheimer Program, UCLA Jonsson Cancer Center Foundation, Margaret E. Early Medical Research Trust, and National Center for Advancing Translational Sciences UCLA Clinical and Translational Science Institute (CTSI) Grant UL1TR000124. D.C. was supported by NIH R01AG082105, R01DK 117481, R01AG063404, and R01AG 063389. E.C.T. was supported by an Irish Research Council Laureate Award IRCLA/2017/58 and Science Foundation Ireland Future Frontiers 19/FFP/6790. J.V. is funded by grants from the US National Institutes of Health (grants U19AG056278, U01HL145560, U01ES029519, P01AG017242, P01AG047200). J.P. would like to acknowledge NIH grants R01AG068048, R01AG82708, UG3CA268103, and P01 AG062413. J.L.K. is supported by the National Institutes of Health (grants R37AG013925 and R33AG061456), the Connor Fund, the Robert J. and Theresa W. Ryan Fund, and the Noaber Foundation. K.M. was supported by NEI of the National Institutes of Health no. 1R43EY034403-01. L.J.N. and P.D.R. are supported by NIH (R01AG063543, U19AG056278, U54AG076041, U54AG079754). M.H. is funded by Longevity Biotech Fellowship. M.Q. from Rubedo Life Sciences received award from California Institute of Regenerative Medicine (CIRM #DISC-14096) for its pharmacological program on targeting senescent lung stem cells in Idiopathic Pulmonary Fibrosis. P.M. is funded from grant number ERC-2016-AdG-741966. Q.F. received a grant from the Shandong Provincial Natural Science Foundation (ZR2023MH262), Yantai Double Hundred Program, University and Locality Collaborative Program (2021XDHZ082). S.L. was supported by the Healthy Longevity Catalyst Awards (Hong Kong): National Academy of Medicine, USA. T.A.R. is supported by grants from NIH AG68667 and AG82764. V.G. is supported by grants from the US National Institute on Aging, Impetus grants, Michael Antonov Foundation. V.S. research is supported by the NUHS Internal Grant Funding under NUS Start-up grant NUHSRO/2022/047/Startup/11. Y-X.L. is supported by grants from the Southern University of Science and Technology, China, and from the Max Planck Society, Germany.

Funders	Funder number
Li Ka Shing Faculty of Medicine, University of Hong Kong
Stockholms Universitet
University of Minnesota
Michael Antonov Foundation
Noaber Foundation
Insilico Medicine
Neye Foundation
Connor Fund
National Center for Advancing Translational Sciences UCLA Clinical and Translational Science Institute
Edythe Broad Center of Regenerative Medicine and Stem Cell Research
Max-Planck-Gesellschaft
Wenner-Gren Institute
Jonsson Cancer Center Foundation
National University Health System
USA 105Department of Molecular Biosciences
European Commission
VitaDAO
Oppenheimer Program
University of Pittsburgh
Margaret E. Early Medical Research Trust
California Institute of Regenerative Medicine
Medicine Canada Inc.
Labs Inc.
Goethe-Universität Frankfurt am Main
European Research Council
National Institute on Aging
Centre for Physical Activity Research
Southern University of Science and Technology
National Eye Institute	R01AG063543, 1R43EY034403-01, U54AG076041, U54AG079754, ERC-2016-AdG-741966
TrygFonden	20045, 125132, ID 101390
Natural Science Foundation of Shandong Province	2021XDHZ082, ZR2023MH262
Irish Research Council	IRCLA/2017/58
Fondation Santé	19656
Lundbeck Foundation	R324-2019-1492
Science Foundation Ireland	19/FFP/6790
National Academy of Medicine	AG82764, AG68667
Max Planck Institute for Molecular Biomedicine, Münster, Germany 107Healthspan Capital	CA 94530
California Institute for Regenerative Medicine	-14096, ERC-2016AdG-741966
Tel Aviv University	CA 90001
National Institutes of Health	CA 94107, U01ES029519, P01AG017242, R01AG063404, R01AG 063389, R33AG061456, UG3CA268103, P01AG047200, U19AG056278, R01DK 117481, R01AG82708, R37AG013925, U01HL145560, R01AG068048, P01 AG062413, R01AG082105
Uddannelses- og Forskningsministeriet	0238-00003B
Wellcome Trust	220784/Z/20/Z
National University of Singapore	NUHSRO/2022/047/Startup/11
Indiana Clinical and Translational Sciences Institute	UL1TR000124
Novo Nordisk Foundation Challenge Programme	NNF17OC0027812
Nordea-fonden	02-2017-1749
University of California	CA 90095

Keywords

Humans
Aging/physiology
Artificial Intelligence
Biomarkers/metabolism
Biotechnology/methods
Geroscience/methods
Longevity/physiology

Access to Document

10.18632/aging.206135

Persistent URL (handle)

Persistent link

Cite this

Lyu, Y.-X., Fu, Q., Wilczok, D., Ying, K., King, A., Antebi, A., Vojta, A., Stolzing, A., Moskalev, A., Georgievskaya, A., Maier, A. B., Olsen, A., Groth, A., Simon, A. K., Brunet, A., Jamil, A., Kulaga, A., Bhatti, A., Yaden, B., ... Bakula, D. (2024). Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging, 16(20), 12955-12976. https://doi.org/10.18632/aging.206135

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title = "Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity",

abstract = "The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.",

keywords = "Humans, Aging/physiology, Artificial Intelligence, Biomarkers/metabolism, Biotechnology/methods, Geroscience/methods, Longevity/physiology",

author = "Yu-Xuan Lyu and Qiang Fu and Dominika Wilczok and Kejun Ying and Aaron King and Adam Antebi and Aleksandar Vojta and Alexandra Stolzing and Alexey Moskalev and Anastasia Georgievskaya and Maier, {Andrea B} and Andrea Olsen and Anja Groth and Simon, {Anna Katharina} and Anne Brunet and Aisyah Jamil and Anton Kulaga and Asif Bhatti and Benjamin Yaden and Pedersen, {Bente Klarlund} and Bj{\"o}rn Schumacher and Boris Djordjevic and Brian Kennedy and Chieh Chen and Huang, {Christine Yuan} and Correll, {Christoph U} and Murphy, {Coleen T} and Ewald, {Collin Y} and Danica Chen and Valenzano, {Dario Riccardo} and Dariusz So{\l}dacki and David Erritzoe and David Meyer and Sinclair, {David A} and Chini, {Eduardo Nunes} and Teeling, {Emma C} and Eric Morgen and Eric Verdin and Erik Vernet and Estefano Pinilla and Fang, {Evandro F} and Evelyne Bischof and Mercken, {Evi M} and Fabian Finger and Folkert Kuipers and Pun, {Frank W} and Gabor Gy{\"u}lveszi and Gabriele Civiletto and Garri Zmudze and Gil Blander and Pincus, {Harold A} and Joshua McClure and Kirkland, {James L} and James Peyer and Justice, {Jamie N} and Jan Vijg and Gruhn, {Jennifer R} and Jerry McLaughlin and Joan Mannick and Jo{\~a}o Passos and Baur, {Joseph A} and Joe Betts-LaCroix and Sedivy, {John M} and Speakman, {John R} and Jordan Shlain and {von Maltzahn}, Julia and Andreasson, {Katrin I} and Kelsey Moody and Konstantinos Palikaras and Kristen Fortney and Niedernhofer, {Laura J} and Rasmussen, {Lene Juel} and Veenhoff, {Liesbeth M} and Lisa Melton and Luigi Ferrucci and Marco Quarta and Maria Koval and Maria Marinova and Mark Hamalainen and Maximilian Unfried and Ringel, {Michael S} and Milos Filipovic and Mourad Topors and Natalia Mitin and Nawal Roy and Nika Pintar and Nir Barzilai and Paolo Binetti and Parminder Singh and Paul Kohlhaas and Robbins, {Paul D} and Paul Rubin and Fedichev, {Peter O} and Petrina Kamya and Pura Mu{\~n}oz-Canoves and {de Cabo}, Rafael and Faragher, {Richard G A} and Rob Konrad and Roberto Ripa and Robin Mansukhani and Sabrina B{\"u}ttner and Wickstr{\"o}m, {Sara A} and Sebastian Brunemeier and Sergey Jakimov and Shan Luo and Sharon Rosenzweig-Lipson and Shih-Yin Tsai and Stefanie Dimmeler and Rando, {Thomas A} and Peterson, {Tim R} and Tina Woods and Tony Wyss-Coray and Toren Finkel and Tzipora Strauss and Gladyshev, {Vadim N} and Longo, {Valter D} and Dwaraka, {Varun B} and Vera Gorbunova and Acosta-Rodr{\'i}guez, {Victoria A} and Vincenzo Sorrentino and Vittorio Sebastiano and Wenbin Li and Yousin Suh and Alex Zhavoronkov and Morten Scheibye-Knudsen and Daniela Bakula",

year = "2024",

month = oct,

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doi = "10.18632/aging.206135",

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volume = "16",

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journal = "Aging",

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Lyu, Y-X, Fu, Q, Wilczok, D, Ying, K, King, A, Antebi, A, Vojta, A, Stolzing, A, Moskalev, A, Georgievskaya, A, Maier, AB, Olsen, A, Groth, A, Simon, AK, Brunet, A, Jamil, A, Kulaga, A, Bhatti, A, Yaden, B, Pedersen, BK, Schumacher, B, Djordjevic, B, Kennedy, B, Chen, C, Huang, CY, Correll, CU, Murphy, CT, Ewald, CY, Chen, D, Valenzano, DR, Sołdacki, D, Erritzoe, D, Meyer, D, Sinclair, DA, Chini, EN, Teeling, EC, Morgen, E, Verdin, E, Vernet, E, Pinilla, E, Fang, EF, Bischof, E, Mercken, EM, Finger, F, Kuipers, F, Pun, FW, Gyülveszi, G, Civiletto, G, Zmudze, G, Blander, G, Pincus, HA, McClure, J, Kirkland, JL, Peyer, J, Justice, JN, Vijg, J, Gruhn, JR, McLaughlin, J, Mannick, J, Passos, J, Baur, JA, Betts-LaCroix, J, Sedivy, JM, Speakman, JR, Shlain, J, von Maltzahn, J, Andreasson, KI, Moody, K, Palikaras, K, Fortney, K, Niedernhofer, LJ, Rasmussen, LJ, Veenhoff, LM, Melton, L, Ferrucci, L, Quarta, M, Koval, M, Marinova, M, Hamalainen, M, Unfried, M, Ringel, MS, Filipovic, M, Topors, M, Mitin, N, Roy, N, Pintar, N, Barzilai, N, Binetti, P, Singh, P, Kohlhaas, P, Robbins, PD, Rubin, P, Fedichev, PO, Kamya, P, Muñoz-Canoves, P, de Cabo, R, Faragher, RGA, Konrad, R, Ripa, R, Mansukhani, R, Büttner, S, Wickström, SA, Brunemeier, S, Jakimov, S, Luo, S, Rosenzweig-Lipson, S, Tsai, S-Y, Dimmeler, S, Rando, TA, Peterson, TR, Woods, T, Wyss-Coray, T, Finkel, T, Strauss, T, Gladyshev, VN, Longo, VD, Dwaraka, VB, Gorbunova, V, Acosta-Rodríguez, VA, Sorrentino, V, Sebastiano, V, Li, W, Suh, Y, Zhavoronkov, A, Scheibye-Knudsen, M & Bakula, D 2024, 'Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity', Aging, vol. 16, no. 20, pp. 12955-12976. https://doi.org/10.18632/aging.206135

TY - JOUR

T1 - Longevity biotechnology

T2 - bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

AU - Lyu, Yu-Xuan

AU - Fu, Qiang

AU - Wilczok, Dominika

AU - Ying, Kejun

AU - King, Aaron

AU - Antebi, Adam

AU - Vojta, Aleksandar

AU - Stolzing, Alexandra

AU - Moskalev, Alexey

AU - Georgievskaya, Anastasia

AU - Maier, Andrea B

AU - Olsen, Andrea

AU - Groth, Anja

AU - Simon, Anna Katharina

AU - Brunet, Anne

AU - Jamil, Aisyah

AU - Kulaga, Anton

AU - Bhatti, Asif

AU - Yaden, Benjamin

AU - Pedersen, Bente Klarlund

AU - Schumacher, Björn

AU - Djordjevic, Boris

AU - Kennedy, Brian

AU - Chen, Chieh

AU - Huang, Christine Yuan

AU - Correll, Christoph U

AU - Murphy, Coleen T

AU - Ewald, Collin Y

AU - Chen, Danica

AU - Valenzano, Dario Riccardo

AU - Sołdacki, Dariusz

AU - Erritzoe, David

AU - Meyer, David

AU - Sinclair, David A

AU - Chini, Eduardo Nunes

AU - Teeling, Emma C

AU - Morgen, Eric

AU - Verdin, Eric

AU - Vernet, Erik

AU - Pinilla, Estefano

AU - Fang, Evandro F

AU - Bischof, Evelyne

AU - Mercken, Evi M

AU - Finger, Fabian

AU - Kuipers, Folkert

AU - Pun, Frank W

AU - Gyülveszi, Gabor

AU - Civiletto, Gabriele

AU - Zmudze, Garri

AU - Blander, Gil

AU - Pincus, Harold A

AU - McClure, Joshua

AU - Kirkland, James L

AU - Peyer, James

AU - Justice, Jamie N

AU - Vijg, Jan

AU - Gruhn, Jennifer R

AU - McLaughlin, Jerry

AU - Mannick, Joan

AU - Passos, João

AU - Baur, Joseph A

AU - Betts-LaCroix, Joe

AU - Sedivy, John M

AU - Speakman, John R

AU - Shlain, Jordan

AU - von Maltzahn, Julia

AU - Andreasson, Katrin I

AU - Moody, Kelsey

AU - Palikaras, Konstantinos

AU - Fortney, Kristen

AU - Niedernhofer, Laura J

AU - Rasmussen, Lene Juel

AU - Veenhoff, Liesbeth M

AU - Melton, Lisa

AU - Ferrucci, Luigi

AU - Quarta, Marco

AU - Koval, Maria

AU - Marinova, Maria

AU - Hamalainen, Mark

AU - Unfried, Maximilian

AU - Ringel, Michael S

AU - Filipovic, Milos

AU - Topors, Mourad

AU - Mitin, Natalia

AU - Roy, Nawal

AU - Pintar, Nika

AU - Barzilai, Nir

AU - Binetti, Paolo

AU - Singh, Parminder

AU - Kohlhaas, Paul

AU - Robbins, Paul D

AU - Rubin, Paul

AU - Fedichev, Peter O

AU - Kamya, Petrina

AU - Muñoz-Canoves, Pura

AU - de Cabo, Rafael

AU - Faragher, Richard G A

AU - Konrad, Rob

AU - Ripa, Roberto

AU - Mansukhani, Robin

AU - Büttner, Sabrina

AU - Wickström, Sara A

AU - Brunemeier, Sebastian

AU - Jakimov, Sergey

AU - Luo, Shan

AU - Rosenzweig-Lipson, Sharon

AU - Tsai, Shih-Yin

AU - Dimmeler, Stefanie

AU - Rando, Thomas A

AU - Peterson, Tim R

AU - Woods, Tina

AU - Wyss-Coray, Tony

AU - Finkel, Toren

AU - Strauss, Tzipora

AU - Gladyshev, Vadim N

AU - Longo, Valter D

AU - Dwaraka, Varun B

AU - Gorbunova, Vera

AU - Acosta-Rodríguez, Victoria A

AU - Sorrentino, Vincenzo

AU - Sebastiano, Vittorio

AU - Li, Wenbin

AU - Suh, Yousin

AU - Zhavoronkov, Alex

AU - Scheibye-Knudsen, Morten

AU - Bakula, Daniela

PY - 2024/10/16

Y1 - 2024/10/16

N2 - The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

AB - The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

KW - Humans

KW - Aging/physiology

KW - Artificial Intelligence

KW - Biomarkers/metabolism

KW - Biotechnology/methods

KW - Geroscience/methods

KW - Longevity/physiology

U2 - 10.18632/aging.206135

DO - 10.18632/aging.206135

M3 - Review article

C2 - 39418098

SN - 1945-4589

VL - 16

SP - 12955

EP - 12976

JO - Aging

JF - Aging

IS - 20

ER -

Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity

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