Low-grade systemic inflammation in overweight children

M. Visser, L.M. Bouter, G.M. McQuillan, M.H. Wener, T.B. Harris

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    OBJECTIVE: Human adipose tissue expresses and releases the proinflammatory cytokine interleukin-6, potentially inducing low-grade systemic inflammation in persons with excess body fat. To limit potential confounding by inflammation-related diseases and subclinical cardiovascular disease, we tested the hypothesis that overweight is associated with low-grade systemic inflammation in children.

    DESIGN AND SETTING: The third National Health and Nutrition Examination Survey, 1988-1994, a representative sample of the US population.

    PARTICIPANTS: A total of 3512 children 8 to 16 years of age.

    OUTCOME MEASURES: Elevated serum C-reactive protein concentration (CRP; >/=.22 mg/dL) and white blood cell count (10(9) cells/L).

    RESULTS: Elevated CRP was present in 7.1% of the boys and 6.1% of the girls. Overweight children (defined as having a body mass index or a sum of 3 skinfolds (triceps, subscapula, and supra-iliac) above the gender-specific 85th percentile) were more likely to have elevated CRP than were their normal-weight counterparts. After adjustment for potential confounders, including smoking and health status, the odds ratio (OR) was 3.74 (95% confidence interval [CI]: 1.66-8.43) for overweight boys and the OR was 3.17 (95% CI: 1.60-6.28) for overweight girls, based on the body mass index. Based on the sum of 3 skinfolds, these ORs were 5.11 (95% CI: 2.36-11.06) and 2.89 (95% CI: 1.49-5.59) for boys and girls, respectively. Overweight was also associated with statistically significant higher white blood cell counts. The results were similar when restricted to healthy, nonsmoking, nonestrogen-using children.

    CONCLUSIONS: In children 8 to 16 years of age, overweight is associated with higher CRP concentrations and higher white blood cell counts. These findings suggest a state of low-grade systemic inflammation in overweight children. inflammation, obesity, children.

    Original languageEnglish
    Pages (from-to)E13
    Number of pages1
    Issue number1
    Publication statusPublished - Jan 2001


    • Adipose Tissue
    • Anthropometry
    • Biomarkers
    • Body Mass Index
    • C-Reactive Protein
    • Child
    • Cluster Analysis
    • Comorbidity
    • Confounding Factors (Epidemiology)
    • Female
    • Humans
    • Inflammation
    • Leukocyte Count
    • Male
    • Obesity
    • United States
    • Journal Article


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