Low-picomolar analysis of peptides by on-line coupling of fritless solid-phase extraction to sheathless capillary electrophoresis-mass spectrometry

S. Medina-Casanellas, E. Domínguez-Vega, F. Benavente, V. Sanz-Nebot, G.W. Somsen, G.J. de Jong

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A novel fritless solid-phase extraction (SPE) microcartridge was designed for combination with sheathless capillary electrophoresis-mass spectrometry (sheathless CE-MS) employing a prototype porous-tip capillary for nanoelectrospray ionization (nanoESI). The inlet of the separation capillary (30μm inner diameter (id), 150μm outer diameter (od)) was inserted in a 4mm long SPE microcartridge (150μm id, 365μm od) packed with a C
Original languageEnglish
Pages (from-to)1-6
JournalJournal of Chromatography A
Volume1328
DOIs
Publication statusPublished - 2014

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