Low-picomolar analysis of peptides by on-line coupling of fritless solid-phase extraction to sheathless capillary electrophoresis-mass spectrometry

S. Medina-Casanellas; E. Domínguez-Vega; F. Benavente; V. Sanz-Nebot; G.W. Somsen; G.J. de Jong

doi:10.1016/j.chroma.2013.12.080

Low-picomolar analysis of peptides by on-line coupling of fritless solid-phase extraction to sheathless capillary electrophoresis-mass spectrometry

S. Medina-Casanellas, E. Domínguez-Vega, F. Benavente, V. Sanz-Nebot, G.W. Somsen, G.J. de Jong

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Abstract

A novel fritless solid-phase extraction (SPE) microcartridge was designed for combination with sheathless capillary electrophoresis-mass spectrometry (sheathless CE-MS) employing a prototype porous-tip capillary for nanoelectrospray ionization (nanoESI). The inlet of the separation capillary (30μm inner diameter (id), 150μm outer diameter (od)) was inserted in a 4mm long SPE microcartridge (150μm id, 365μm od) packed with a C

Original language	English
Pages (from-to)	1-6
Journal	Journal of Chromatography A
Volume	1328
DOIs	https://doi.org/10.1016/j.chroma.2013.12.080
Publication status	Published - 2014

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10.1016/j.chroma.2013.12.080

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title = "Low-picomolar analysis of peptides by on-line coupling of fritless solid-phase extraction to sheathless capillary electrophoresis-mass spectrometry",

abstract = "A novel fritless solid-phase extraction (SPE) microcartridge was designed for combination with sheathless capillary electrophoresis-mass spectrometry (sheathless CE-MS) employing a prototype porous-tip capillary for nanoelectrospray ionization (nanoESI). The inlet of the separation capillary (30μm inner diameter (id), 150μm outer diameter (od)) was inserted in a 4mm long SPE microcartridge (150μm id, 365μm od) packed with a C",

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AU - Medina-Casanellas, S.

AU - Domínguez-Vega, E.

AU - Benavente, F.

AU - Sanz-Nebot, V.

AU - Somsen, G.W.

AU - de Jong, G.J.

PY - 2014

Y1 - 2014

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AB - A novel fritless solid-phase extraction (SPE) microcartridge was designed for combination with sheathless capillary electrophoresis-mass spectrometry (sheathless CE-MS) employing a prototype porous-tip capillary for nanoelectrospray ionization (nanoESI). The inlet of the separation capillary (30μm inner diameter (id), 150μm outer diameter (od)) was inserted in a 4mm long SPE microcartridge (150μm id, 365μm od) packed with a C

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DO - 10.1016/j.chroma.2013.12.080

M3 - Article

SN - 0021-9673

VL - 1328

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EP - 6

JO - Journal of Chromatography A

JF - Journal of Chromatography A

ER -

Low-picomolar analysis of peptides by on-line coupling of fritless solid-phase extraction to sheathless capillary electrophoresis-mass spectrometry

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