Lower cognitive function in older patients with lower muscle strength and muscle mass

Romee Van Dam; Jeanine M. Van Ancum; Sjors Verlaan; Kira Scheerman; Carel G.M. Meskers; Andrea B. Maier

doi:10.1159/000486711

Lower cognitive function in older patients with lower muscle strength and muscle mass

Romee Van Dam, Jeanine M. Van Ancum, Sjors Verlaan, Kira Scheerman, Carel G.M. Meskers, Andrea B. Maier

Biomechanics

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND: Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients.

METHODS: This prospective inception cohort included 378 patients aged 70 years or older. At admission patients were assessed for cognitive functioning by use of the Six-Item Cognitive Impairment Test (6-CIT). Muscle strength and muscle mass were assessed using handheld dynamometry and segmental multifrequency bioelectrical impedance analysis, within 48 h after admission and on day 7, or earlier on the day of discharge.

RESULTS: The data of 371 patients (mean age ± standard deviation 80.1 ± 6.4 years, 49.3% female) were available for analyses. The median (interquartile range) 6-CIT score was 4 (0-8) points. At admission, lower cognitive functioning was associated with lower muscle strength, lower skeletal muscle mass (SMM), lower appendicular lean mass, and lower SMM index. Cognitive functioning was not associated with change in muscle strength and muscle mass during hospitalization.

CONCLUSION: This study further strengthens evidence for an association between lower cognitive functioning and lower muscle strength and muscle mass, but without a further decline during hospitalization.

Original language	English
Pages (from-to)	243-250
Number of pages	8
Journal	Dementia and Geriatric Cognitive Disorders
Volume	45
Issue number	3-4
Early online date	18 Jun 2018
DOIs	https://doi.org/10.1159/000486711
Publication status	Published - Jul 2018

Bibliographical note

Funding

This work was supported by the seventh framework program MYOAGE [HEALTH-2007-2.4.5-10]; the European Union’s Horizon 2020 research and innovation program [689238, 675003], and Nutricia Research, Nutricia Advanced Medical Nutrition, The Netherlands.

Funders	Funder number
European Union’s Horizon 2020 research and innovation program	689238, 675003
Nutricia Advanced Medical Nutrition
Nutricia Research Foundation
seventh framework program MYOAGE	HEALTH-2007-2.4.5-10

Keywords

Aged
Aged, 80 and over
Cognition
Cognitive Dysfunction/diagnosis
Female
Geriatric Assessment/methods
Hospitalization/statistics & numerical data
Humans
Male
Muscle Strength
Muscle Weakness/diagnosis
Muscle, Skeletal/pathology
Netherlands
Prospective Studies
Statistics as Topic

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10.1159/000486711

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title = "Lower cognitive function in older patients with lower muscle strength and muscle mass",

abstract = "BACKGROUND: Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients.METHODS: This prospective inception cohort included 378 patients aged 70 years or older. At admission patients were assessed for cognitive functioning by use of the Six-Item Cognitive Impairment Test (6-CIT). Muscle strength and muscle mass were assessed using handheld dynamometry and segmental multifrequency bioelectrical impedance analysis, within 48 h after admission and on day 7, or earlier on the day of discharge.RESULTS: The data of 371 patients (mean age ± standard deviation 80.1 ± 6.4 years, 49.3% female) were available for analyses. The median (interquartile range) 6-CIT score was 4 (0-8) points. At admission, lower cognitive functioning was associated with lower muscle strength, lower skeletal muscle mass (SMM), lower appendicular lean mass, and lower SMM index. Cognitive functioning was not associated with change in muscle strength and muscle mass during hospitalization.CONCLUSION: This study further strengthens evidence for an association between lower cognitive functioning and lower muscle strength and muscle mass, but without a further decline during hospitalization.",

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AU - Van Ancum, Jeanine M.

AU - Verlaan, Sjors

AU - Scheerman, Kira

AU - Meskers, Carel G.M.

AU - Maier, Andrea B.

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AB - BACKGROUND: Low muscle strength and muscle mass are associated with adverse outcomes in older hospitalized patients. The aim of this study was to assess the association between cognitive functioning and muscle strength and muscle mass in hospitalized older patients.METHODS: This prospective inception cohort included 378 patients aged 70 years or older. At admission patients were assessed for cognitive functioning by use of the Six-Item Cognitive Impairment Test (6-CIT). Muscle strength and muscle mass were assessed using handheld dynamometry and segmental multifrequency bioelectrical impedance analysis, within 48 h after admission and on day 7, or earlier on the day of discharge.RESULTS: The data of 371 patients (mean age ± standard deviation 80.1 ± 6.4 years, 49.3% female) were available for analyses. The median (interquartile range) 6-CIT score was 4 (0-8) points. At admission, lower cognitive functioning was associated with lower muscle strength, lower skeletal muscle mass (SMM), lower appendicular lean mass, and lower SMM index. Cognitive functioning was not associated with change in muscle strength and muscle mass during hospitalization.CONCLUSION: This study further strengthens evidence for an association between lower cognitive functioning and lower muscle strength and muscle mass, but without a further decline during hospitalization.

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Lower cognitive function in older patients with lower muscle strength and muscle mass

Abstract

Bibliographical note

Funding

Keywords

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Supplementary Material for: Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass

Supplementary Material for: Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass

Cite this

Lower cognitive function in older patients with lower muscle strength and muscle mass

Abstract

Bibliographical note

Funding

Keywords

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Datasets

Supplementary Material for: Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass

Supplementary Material for: Lower Cognitive Function in Older Patients with Lower Muscle Strength and Muscle Mass

Cite this