Malnutrition risk and frailty in head and neck cancer patients: coexistent but distinct conditions

Priya Dewansingh; Linda Bras; Lies ter Beek; Wim P. Krijnen; Jan L.N. Roodenburg; Cees P. van der Schans; Gyorgy B. Halmos; Harriët Jager-Wittenaar

doi:10.1007/s00405-022-07728-6

Malnutrition risk and frailty in head and neck cancer patients: coexistent but distinct conditions

Priya Dewansingh, Linda Bras^*, Lies ter Beek, Wim P. Krijnen, Jan L.N. Roodenburg, Cees P. van der Schans, Gyorgy B. Halmos, Harriët Jager-Wittenaar

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

PURPOSE: Both malnutrition and frailty are associated with adverse treatment outcomes. Malnutrition (risk) and frailty are each commonly present in patients with head and neck cancer (HNC). However, their coexistence and association is unknown. Main goal of this study is to determine the coexistence of, and the association between malnutrition risk and frailty in patients with HNC.

METHODS: In this retrospective analysis on prospectively collected data, newly diagnosed patients with HNC, enrolled in the OncoLifeS databiobank were included. The Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF) was used to assess malnutrition risk. The Groningen Frailty Indicator (GFI) was used to assess frailty status. Multivariate logistic regression analyses were performed, taking into account several patient- and tumor-related factors.

RESULTS: In total, 197 patients were included. Seventy-six patients (39%) had a medium or high malnutrition risk and 71 patients (36%) were frail. In 38 patients (19%), malnutrition risk coexisted with frailty. Patients with medium and high malnutrition risk were, respectively, 4.0 (95% CI 1.5-11.2) and 13.4 (95% CI 4.0-48.7) times more likely to be frail, compared to patients with low malnutrition risk. In turn, frail patients were 6.4 times (95% CI 2.6-14.9) more likely to have malnutrition risk compared to non-frail patients.

CONCLUSIONS: Malnutrition risk and frailty frequently coexist but not fully overlap in newly diagnosed patients with HNC. Therefore, screening for both conditions is recommended.

Original language	English
Pages (from-to)	1893-1902
Number of pages	10
Journal	European Archives of Oto-Rhino-Laryngology
Volume	280
Issue number	4
Early online date	9 Dec 2022
DOIs	https://doi.org/10.1007/s00405-022-07728-6
Publication status	Published - Apr 2023

Bibliographical note

Funding Information:
The authors thank the patients for participating in the study, and the medical administration and nurses from the Department of Otorhinolaryngology/Head and Neck Surgery of the UMCG for their help with the data collection.

Publisher Copyright:
© 2022, The Author(s).

Keywords

Frailty
Head and neck cancer
Malnutrition risk
Oncology
PG-SGA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00405-022-07728-6

Persistent URL (handle)

Copy link address

Cite this

@article{dd08c2a23bd24ed4ac0e27eaef6768b6,

title = "Malnutrition risk and frailty in head and neck cancer patients: coexistent but distinct conditions",

abstract = "PURPOSE: Both malnutrition and frailty are associated with adverse treatment outcomes. Malnutrition (risk) and frailty are each commonly present in patients with head and neck cancer (HNC). However, their coexistence and association is unknown. Main goal of this study is to determine the coexistence of, and the association between malnutrition risk and frailty in patients with HNC.METHODS: In this retrospective analysis on prospectively collected data, newly diagnosed patients with HNC, enrolled in the OncoLifeS databiobank were included. The Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF) was used to assess malnutrition risk. The Groningen Frailty Indicator (GFI) was used to assess frailty status. Multivariate logistic regression analyses were performed, taking into account several patient- and tumor-related factors.RESULTS: In total, 197 patients were included. Seventy-six patients (39%) had a medium or high malnutrition risk and 71 patients (36%) were frail. In 38 patients (19%), malnutrition risk coexisted with frailty. Patients with medium and high malnutrition risk were, respectively, 4.0 (95% CI 1.5-11.2) and 13.4 (95% CI 4.0-48.7) times more likely to be frail, compared to patients with low malnutrition risk. In turn, frail patients were 6.4 times (95% CI 2.6-14.9) more likely to have malnutrition risk compared to non-frail patients.CONCLUSIONS: Malnutrition risk and frailty frequently coexist but not fully overlap in newly diagnosed patients with HNC. Therefore, screening for both conditions is recommended.",

keywords = "Frailty, Head and neck cancer, Malnutrition risk, Oncology, PG-SGA",

author = "Priya Dewansingh and Linda Bras and {ter Beek}, Lies and Krijnen, {Wim P.} and Roodenburg, {Jan L.N.} and {van der Schans}, {Cees P.} and Halmos, {Gyorgy B.} and Harri{\"e}t Jager-Wittenaar",

note = "Funding Information: The authors thank the patients for participating in the study, and the medical administration and nurses from the Department of Otorhinolaryngology/Head and Neck Surgery of the UMCG for their help with the data collection. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2023",

month = apr,

doi = "10.1007/s00405-022-07728-6",

language = "English",

volume = "280",

pages = "1893--1902",

journal = "European Archives of Oto-Rhino-Laryngology",

issn = "0937-4477",

publisher = "Springer Verlag",

number = "4",

}

TY - JOUR

T1 - Malnutrition risk and frailty in head and neck cancer patients: coexistent but distinct conditions

AU - Dewansingh, Priya

AU - Bras, Linda

AU - ter Beek, Lies

AU - Krijnen, Wim P.

AU - Roodenburg, Jan L.N.

AU - van der Schans, Cees P.

AU - Halmos, Gyorgy B.

AU - Jager-Wittenaar, Harriët

N1 - Funding Information: The authors thank the patients for participating in the study, and the medical administration and nurses from the Department of Otorhinolaryngology/Head and Neck Surgery of the UMCG for their help with the data collection. Publisher Copyright: © 2022, The Author(s).

PY - 2023/4

Y1 - 2023/4

N2 - PURPOSE: Both malnutrition and frailty are associated with adverse treatment outcomes. Malnutrition (risk) and frailty are each commonly present in patients with head and neck cancer (HNC). However, their coexistence and association is unknown. Main goal of this study is to determine the coexistence of, and the association between malnutrition risk and frailty in patients with HNC.METHODS: In this retrospective analysis on prospectively collected data, newly diagnosed patients with HNC, enrolled in the OncoLifeS databiobank were included. The Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF) was used to assess malnutrition risk. The Groningen Frailty Indicator (GFI) was used to assess frailty status. Multivariate logistic regression analyses were performed, taking into account several patient- and tumor-related factors.RESULTS: In total, 197 patients were included. Seventy-six patients (39%) had a medium or high malnutrition risk and 71 patients (36%) were frail. In 38 patients (19%), malnutrition risk coexisted with frailty. Patients with medium and high malnutrition risk were, respectively, 4.0 (95% CI 1.5-11.2) and 13.4 (95% CI 4.0-48.7) times more likely to be frail, compared to patients with low malnutrition risk. In turn, frail patients were 6.4 times (95% CI 2.6-14.9) more likely to have malnutrition risk compared to non-frail patients.CONCLUSIONS: Malnutrition risk and frailty frequently coexist but not fully overlap in newly diagnosed patients with HNC. Therefore, screening for both conditions is recommended.

AB - PURPOSE: Both malnutrition and frailty are associated with adverse treatment outcomes. Malnutrition (risk) and frailty are each commonly present in patients with head and neck cancer (HNC). However, their coexistence and association is unknown. Main goal of this study is to determine the coexistence of, and the association between malnutrition risk and frailty in patients with HNC.METHODS: In this retrospective analysis on prospectively collected data, newly diagnosed patients with HNC, enrolled in the OncoLifeS databiobank were included. The Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF) was used to assess malnutrition risk. The Groningen Frailty Indicator (GFI) was used to assess frailty status. Multivariate logistic regression analyses were performed, taking into account several patient- and tumor-related factors.RESULTS: In total, 197 patients were included. Seventy-six patients (39%) had a medium or high malnutrition risk and 71 patients (36%) were frail. In 38 patients (19%), malnutrition risk coexisted with frailty. Patients with medium and high malnutrition risk were, respectively, 4.0 (95% CI 1.5-11.2) and 13.4 (95% CI 4.0-48.7) times more likely to be frail, compared to patients with low malnutrition risk. In turn, frail patients were 6.4 times (95% CI 2.6-14.9) more likely to have malnutrition risk compared to non-frail patients.CONCLUSIONS: Malnutrition risk and frailty frequently coexist but not fully overlap in newly diagnosed patients with HNC. Therefore, screening for both conditions is recommended.

KW - Frailty

KW - Head and neck cancer

KW - Malnutrition risk

KW - Oncology

KW - PG-SGA

UR - http://www.scopus.com/inward/record.url?scp=85143501429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85143501429&partnerID=8YFLogxK

U2 - 10.1007/s00405-022-07728-6

DO - 10.1007/s00405-022-07728-6

M3 - Article

C2 - 36484854

SN - 0937-4477

VL - 280

SP - 1893

EP - 1902

JO - European Archives of Oto-Rhino-Laryngology

JF - European Archives of Oto-Rhino-Laryngology

IS - 4

ER -

Malnutrition risk and frailty in head and neck cancer patients: coexistent but distinct conditions

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this