Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium

Karolinska Schizophrenia Project (KaSP), Karolinska Schizophrenia Project (KaSP) consortium, ENIGMA Laterality Working Group

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.

Original languageEnglish
Pages (from-to)E5154-E5163
JournalProceedings of the National Academy of Sciences of the United States of America
Volume115
Issue number22
DOIs
Publication statusPublished - 29 May 2018

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Brain Mapping
Neuroimaging
Meta-Analysis
Brain
Parahippocampal Gyrus
Entorhinal Cortex
Functional Laterality
Auditory Cortex
Pedigree
Prefrontal Cortex
Nervous System Diseases
Psychiatry
Language
Magnetic Resonance Imaging
Population
Datasets

Keywords

  • Brain asymmetry
  • Cortical thickness
  • Lateralization
  • Meta-analysis
  • Surface area

Cite this

Karolinska Schizophrenia Project (KaSP), Karolinska Schizophrenia Project (KaSP) consortium, & ENIGMA Laterality Working Group (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium. Proceedings of the National Academy of Sciences of the United States of America, 115(22), E5154-E5163. https://doi.org/10.1073/pnas.1718418115
Karolinska Schizophrenia Project (KaSP) ; Karolinska Schizophrenia Project (KaSP) consortium ; ENIGMA Laterality Working Group. / Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium. In: Proceedings of the National Academy of Sciences of the United States of America. 2018 ; Vol. 115, No. 22. pp. E5154-E5163.
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Karolinska Schizophrenia Project (KaSP), Karolinska Schizophrenia Project (KaSP) consortium & ENIGMA Laterality Working Group 2018, 'Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium' Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 22, pp. E5154-E5163. https://doi.org/10.1073/pnas.1718418115

Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium. / Karolinska Schizophrenia Project (KaSP); Karolinska Schizophrenia Project (KaSP) consortium; ENIGMA Laterality Working Group.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 22, 29.05.2018, p. E5154-E5163.

Research output: Contribution to JournalArticleAcademicpeer-review

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AU - Kong, Xiang Zhen

AU - Mathias, Samuel R.

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AU - Akudjedu, Theophilus N.

AU - Aleman, Andre

AU - Alhusaini, Saud

AU - Allen, Nicholas B.

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AU - Andreassen, Ole A.

AU - Vasquez, Alejandro Arias

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AU - Bastin, Mark E.

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AU - Bauer, Jochen

AU - Baune, Bernhard T.

AU - Baur-Streubel, Ramona

AU - Biederman, Joseph

AU - Blaine, Sara K.

AU - Boedhoe, Premika

AU - Bøen, Erlend

AU - Bose, Anushree

AU - Bralten, Janita

AU - Brandeis, Daniel

AU - Brem, Silvia

AU - Brodaty, Henry

AU - Yüksel, Dilara

AU - Brooks, Samantha J.

AU - Buitelaar, Jan

AU - Bürger, Christian

AU - Bülow, Robin

AU - Calhoun, Vince

AU - Calvo, Anna

AU - Canales-Rodríguez, Erick Jorge

AU - Canive, Jose M.

AU - Cannon, Dara M.

AU - Caparelli, Elisabeth C.

AU - Castellanos, Francisco X.

AU - Cavalleri, Gianpiero L.

AU - Cendes, Fernando

AU - Chaim-Avancini, Tiffany Moukbel

AU - Chantiluke, Kaylita

AU - Chen, Qun Lin

AU - Chen, Xiayu

AU - Cheng, Yuqi

AU - Goudriaan, Anna E.

AU - Heslenfeld, Dirk

AU - Oosterlaan, Jaap

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KW - Lateralization

KW - Meta-analysis

KW - Surface area

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Karolinska Schizophrenia Project (KaSP), Karolinska Schizophrenia Project (KaSP) consortium, ENIGMA Laterality Working Group. Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA consortium. Proceedings of the National Academy of Sciences of the United States of America. 2018 May 29;115(22):E5154-E5163. https://doi.org/10.1073/pnas.1718418115