Mapping short reads to a genomic sequence with circular structure

Costas S. Iliopoulos, Tewogboye A. Okanlawon, Solon P. Pissis, German Tischler

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

Abstract

The constant advances in sequencing technology are turning whole-genome sequencing into a routine procedure, resulting in massive amounts of data that need to be processed. Tens of gigabytes of data in the form of short reads need to be mapped back to reference sequences, a few gigabases long. These high-throughput (or next-generation) technologies allow researchers to characterise a bacterial genome during a single experiment and at a moderate cost. In this paper, as most of the bacteria have a single circular chromosome, we present a simple, yet efficient, accurate and consistent algorithm, to solve the practical problem of matching millions of short reads to a genomic sequence with circular structure.

Original languageEnglish
Title of host publicationITAB 2010 - 10th International Conference on Information Technology and Applications in Biomedicine
Subtitle of host publicationEmerging Technologies for Patient Specific Healthcare
DOIs
Publication statusPublished - 1 Dec 2010
Externally publishedYes
Event10th International Conference on Information Technology and Applications in Biomedicine: Emerging Technologies for Patient Specific Healthcare, ITAB 2010 - Corfu, Greece
Duration: 2 Nov 20105 Nov 2010

Publication series

NameProceedings of the IEEE/EMBS Region 8 International Conference on Information Technology Applications in Biomedicine, ITAB

Conference

Conference10th International Conference on Information Technology and Applications in Biomedicine: Emerging Technologies for Patient Specific Healthcare, ITAB 2010
CountryGreece
CityCorfu
Period2/11/105/11/10

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