Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin

Gino Agbota, Katja Polman, Frank T. Wieringa, Maiza Campos-Ponce, Manfred Accrombessi, Emmanuel Yovo, Clémentine Roucher, Sem Ezinmègnon, Javier Yugueros Marcos, Laurence Vachot, Pierre Tissières, Achille Massougbodji, Nadine Fievet, Michel Cot, Valérie Briand

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background Malaria and schistosomiasis represent two of the most prevalent and disabling parasitic infections in developing countries. Few studies have evaluated the effect of maternal schistosomiasis and malaria in the peri-conceptional period on infant’s risk of infection. Methods In Benin, women were followed from the preconception period until delivery. Subsequently, their children were followed from birth to 3 months of age. Pre-pregnancy malaria, malaria in pregnancy (MiP)—determined monthly using a thick blood smear—and urinary schistosomiasis—determined once before pregnancy and once at delivery using urine filtration—were the main maternal exposures. Infant’s febrile infection (fever with respiratory, gastrointestinal and/or cutaneous clinical signs anytime during follow-up) was the main outcome. In a secondary analysis, we checked the relation of malaria and schistosomiasis with infant’s hemoglobin (Hb) concentration. Both effects were separately assessed using logistic/mixed linear regression models. Results The prevalence of MiP was 35.7% with 10.8% occurring during the 1st trimester, and the prevalence of schistosomiasis was 21.8%. From birth to 3 months, 25.3% of infants had at least one episode of febrile infection. In multivariate analysis, MiP, particularly malaria in the 1st trimester, was significantly associated with a higher risk of infant’s febrile infection (aOR = 4.99 [1.1; 22.6], p = 0.03). In secondary results, pre-pregnancy malaria and schistosomiasis were significantly associated with a lower infant’s Hb concentration during the first 3 months. Conclusion We evidenced the deleterious effect of maternal parasitic infections on infant’s health. Our results argue in favor of the implementation of preventive strategies as early as in the peri-conception.

Original languageEnglish
Article numbere0222864
Pages (from-to)1-13
Number of pages13
JournalPLoS ONE
Volume14
Issue number9
DOIs
Publication statusPublished - 19 Sep 2019

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Benin
schistosomiasis
Schistosomiasis
malaria
Malaria
fever
Hemoglobins
Fever
Mothers
Infection
Developing countries
Linear regression
pregnancy
infection
Logistics
Pregnancy
Blood
Health
Parasitic Diseases
parasitoses

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Agbota, Gino ; Polman, Katja ; Wieringa, Frank T. ; Campos-Ponce, Maiza ; Accrombessi, Manfred ; Yovo, Emmanuel ; Roucher, Clémentine ; Ezinmègnon, Sem ; Marcos, Javier Yugueros ; Vachot, Laurence ; Tissières, Pierre ; Massougbodji, Achille ; Fievet, Nadine ; Cot, Michel ; Briand, Valérie. / Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life : A mother-child cohort in Benin. In: PLoS ONE. 2019 ; Vol. 14, No. 9. pp. 1-13.
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title = "Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin",
abstract = "Background Malaria and schistosomiasis represent two of the most prevalent and disabling parasitic infections in developing countries. Few studies have evaluated the effect of maternal schistosomiasis and malaria in the peri-conceptional period on infant’s risk of infection. Methods In Benin, women were followed from the preconception period until delivery. Subsequently, their children were followed from birth to 3 months of age. Pre-pregnancy malaria, malaria in pregnancy (MiP)—determined monthly using a thick blood smear—and urinary schistosomiasis—determined once before pregnancy and once at delivery using urine filtration—were the main maternal exposures. Infant’s febrile infection (fever with respiratory, gastrointestinal and/or cutaneous clinical signs anytime during follow-up) was the main outcome. In a secondary analysis, we checked the relation of malaria and schistosomiasis with infant’s hemoglobin (Hb) concentration. Both effects were separately assessed using logistic/mixed linear regression models. Results The prevalence of MiP was 35.7{\%} with 10.8{\%} occurring during the 1st trimester, and the prevalence of schistosomiasis was 21.8{\%}. From birth to 3 months, 25.3{\%} of infants had at least one episode of febrile infection. In multivariate analysis, MiP, particularly malaria in the 1st trimester, was significantly associated with a higher risk of infant’s febrile infection (aOR = 4.99 [1.1; 22.6], p = 0.03). In secondary results, pre-pregnancy malaria and schistosomiasis were significantly associated with a lower infant’s Hb concentration during the first 3 months. Conclusion We evidenced the deleterious effect of maternal parasitic infections on infant’s health. Our results argue in favor of the implementation of preventive strategies as early as in the peri-conception.",
author = "Gino Agbota and Katja Polman and Wieringa, {Frank T.} and Maiza Campos-Ponce and Manfred Accrombessi and Emmanuel Yovo and Cl{\'e}mentine Roucher and Sem Ezinm{\`e}gnon and Marcos, {Javier Yugueros} and Laurence Vachot and Pierre Tissi{\`e}res and Achille Massougbodji and Nadine Fievet and Michel Cot and Val{\'e}rie Briand",
year = "2019",
month = "9",
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Agbota, G, Polman, K, Wieringa, FT, Campos-Ponce, M, Accrombessi, M, Yovo, E, Roucher, C, Ezinmègnon, S, Marcos, JY, Vachot, L, Tissières, P, Massougbodji, A, Fievet, N, Cot, M & Briand, V 2019, 'Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin' PLoS ONE, vol. 14, no. 9, e0222864, pp. 1-13. https://doi.org/10.1371/journal.pone.0222864

Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life : A mother-child cohort in Benin. / Agbota, Gino; Polman, Katja; Wieringa, Frank T.; Campos-Ponce, Maiza; Accrombessi, Manfred; Yovo, Emmanuel; Roucher, Clémentine; Ezinmègnon, Sem; Marcos, Javier Yugueros; Vachot, Laurence; Tissières, Pierre; Massougbodji, Achille; Fievet, Nadine; Cot, Michel; Briand, Valérie.

In: PLoS ONE, Vol. 14, No. 9, e0222864, 19.09.2019, p. 1-13.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life

T2 - A mother-child cohort in Benin

AU - Agbota, Gino

AU - Polman, Katja

AU - Wieringa, Frank T.

AU - Campos-Ponce, Maiza

AU - Accrombessi, Manfred

AU - Yovo, Emmanuel

AU - Roucher, Clémentine

AU - Ezinmègnon, Sem

AU - Marcos, Javier Yugueros

AU - Vachot, Laurence

AU - Tissières, Pierre

AU - Massougbodji, Achille

AU - Fievet, Nadine

AU - Cot, Michel

AU - Briand, Valérie

PY - 2019/9/19

Y1 - 2019/9/19

N2 - Background Malaria and schistosomiasis represent two of the most prevalent and disabling parasitic infections in developing countries. Few studies have evaluated the effect of maternal schistosomiasis and malaria in the peri-conceptional period on infant’s risk of infection. Methods In Benin, women were followed from the preconception period until delivery. Subsequently, their children were followed from birth to 3 months of age. Pre-pregnancy malaria, malaria in pregnancy (MiP)—determined monthly using a thick blood smear—and urinary schistosomiasis—determined once before pregnancy and once at delivery using urine filtration—were the main maternal exposures. Infant’s febrile infection (fever with respiratory, gastrointestinal and/or cutaneous clinical signs anytime during follow-up) was the main outcome. In a secondary analysis, we checked the relation of malaria and schistosomiasis with infant’s hemoglobin (Hb) concentration. Both effects were separately assessed using logistic/mixed linear regression models. Results The prevalence of MiP was 35.7% with 10.8% occurring during the 1st trimester, and the prevalence of schistosomiasis was 21.8%. From birth to 3 months, 25.3% of infants had at least one episode of febrile infection. In multivariate analysis, MiP, particularly malaria in the 1st trimester, was significantly associated with a higher risk of infant’s febrile infection (aOR = 4.99 [1.1; 22.6], p = 0.03). In secondary results, pre-pregnancy malaria and schistosomiasis were significantly associated with a lower infant’s Hb concentration during the first 3 months. Conclusion We evidenced the deleterious effect of maternal parasitic infections on infant’s health. Our results argue in favor of the implementation of preventive strategies as early as in the peri-conception.

AB - Background Malaria and schistosomiasis represent two of the most prevalent and disabling parasitic infections in developing countries. Few studies have evaluated the effect of maternal schistosomiasis and malaria in the peri-conceptional period on infant’s risk of infection. Methods In Benin, women were followed from the preconception period until delivery. Subsequently, their children were followed from birth to 3 months of age. Pre-pregnancy malaria, malaria in pregnancy (MiP)—determined monthly using a thick blood smear—and urinary schistosomiasis—determined once before pregnancy and once at delivery using urine filtration—were the main maternal exposures. Infant’s febrile infection (fever with respiratory, gastrointestinal and/or cutaneous clinical signs anytime during follow-up) was the main outcome. In a secondary analysis, we checked the relation of malaria and schistosomiasis with infant’s hemoglobin (Hb) concentration. Both effects were separately assessed using logistic/mixed linear regression models. Results The prevalence of MiP was 35.7% with 10.8% occurring during the 1st trimester, and the prevalence of schistosomiasis was 21.8%. From birth to 3 months, 25.3% of infants had at least one episode of febrile infection. In multivariate analysis, MiP, particularly malaria in the 1st trimester, was significantly associated with a higher risk of infant’s febrile infection (aOR = 4.99 [1.1; 22.6], p = 0.03). In secondary results, pre-pregnancy malaria and schistosomiasis were significantly associated with a lower infant’s Hb concentration during the first 3 months. Conclusion We evidenced the deleterious effect of maternal parasitic infections on infant’s health. Our results argue in favor of the implementation of preventive strategies as early as in the peri-conception.

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