TY - JOUR
T1 - Maternal mortality due to cardiac disease in low- and middle-income countries
AU - Heemelaar, Steffie
AU - Petrus, Annelieke
AU - Knight, Marian
AU - van den Akker, Thomas
PY - 2020/6
Y1 - 2020/6
N2 - Objectives: To assess the frequency of maternal death (MD) due to cardiac disease in low- and middle-income countries (LMIC). Methods: Systematic review searching Medline, EMBASE, Web of Science, Cochrane Library, Emcare, LILACS, African Index Medicus, IMEMR, IndMED, WPRIM, IMSEAR up to 01/Nov/2017. Maternal mortality reports from LMIC reviewing all MD in a given geographical area were included. Hospital-based reports or those solely based on verbal autopsies were excluded. Numbers of MD and cardiac-related deaths were extracted. We calculated cardiac disease MMR (cMMR, cardiac-related MD/100 000 live births) and proportion of cardiac-related MDs among all MDs. Frequency of cardiac MD was compared with the MMR of the country. Results: Forty-seven reports were included, which reported on 38,486 maternal deaths in LMIC. Reported cMMR ranged from 0/100 000 live births (Moldova, Ghana) to 31.9/100 000 (Zimbabwe). The proportion of cardiac-related MD ranged from 0% (Moldova, Ghana) to 24.8% (Sri Lanka). In countries with a higher MMR, cMMR was also higher. However, the proportion of cardiac-related MD was higher in countries with a lower MMR. Conclusions: The burden of cardiac-related mortality is difficult to assess due limited availability of mortality reports. The proportion of cardiac deaths among all MD appeared to be higher in countries with a lower MMR. This is in line with what has been called ‘obstetric transition’: pre-existing medical diseases including cardiac disease are becoming relatively more important where the MMR falls.
AB - Objectives: To assess the frequency of maternal death (MD) due to cardiac disease in low- and middle-income countries (LMIC). Methods: Systematic review searching Medline, EMBASE, Web of Science, Cochrane Library, Emcare, LILACS, African Index Medicus, IMEMR, IndMED, WPRIM, IMSEAR up to 01/Nov/2017. Maternal mortality reports from LMIC reviewing all MD in a given geographical area were included. Hospital-based reports or those solely based on verbal autopsies were excluded. Numbers of MD and cardiac-related deaths were extracted. We calculated cardiac disease MMR (cMMR, cardiac-related MD/100 000 live births) and proportion of cardiac-related MDs among all MDs. Frequency of cardiac MD was compared with the MMR of the country. Results: Forty-seven reports were included, which reported on 38,486 maternal deaths in LMIC. Reported cMMR ranged from 0/100 000 live births (Moldova, Ghana) to 31.9/100 000 (Zimbabwe). The proportion of cardiac-related MD ranged from 0% (Moldova, Ghana) to 24.8% (Sri Lanka). In countries with a higher MMR, cMMR was also higher. However, the proportion of cardiac-related MD was higher in countries with a lower MMR. Conclusions: The burden of cardiac-related mortality is difficult to assess due limited availability of mortality reports. The proportion of cardiac deaths among all MD appeared to be higher in countries with a lower MMR. This is in line with what has been called ‘obstetric transition’: pre-existing medical diseases including cardiac disease are becoming relatively more important where the MMR falls.
KW - cardiac disease
KW - low- and middle-income countries
KW - maternal mortality
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U2 - 10.1111/tmi.13386
DO - 10.1111/tmi.13386
M3 - Article
C2 - 32133737
AN - SCOPUS:85082874285
SN - 1360-2276
VL - 25
SP - 673
EP - 686
JO - Tropical Medicine and International Health
JF - Tropical Medicine and International Health
IS - 6
ER -