Maternal obesity and attention-related symptoms in the preterm offspring

Jelske W van der Burg; Elizabeth T Jensen; Margot van de Bor; Robert M Joseph; T Michael O'Shea; Karl Kuban; Elizabeth N Allred; Megan Scott; Scott Hunter; Stephen R Hooper; Olaf Dammann; Alan Leviton

doi:10.1016/j.earlhumdev.2017.08.002

Maternal obesity and attention-related symptoms in the preterm offspring

Jelske W van der Burg, Elizabeth T Jensen, Margot van de Bor, Robert M Joseph, T Michael O'Shea, Karl Kuban, Elizabeth N Allred, Megan Scott, Scott Hunter, Stephen R Hooper, Olaf Dammann, Alan Leviton

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Abstract

BACKGROUND: Maternal pre-pregnancy obesity, in term-born children, is associated with an increased risk of attention problems, however this relationship has not been explored among children born extremely preterm.

AIM: To estimate the risk of attention problems at age 10years in children born very preterm to overweight (i.e., body mass index (BMI) 25-29kg/m2) and obese (i.e., BMI≥30kg/m2) women relative to the risk among children born to women who were neither overweight nor obese (i.e. BMI<25kg/m2).

STUDY DESIGN: Multi-center prospective cohort study.

METHODS: A total of 764 children born before the 28th week of gestation and whose mother's pre-pregnancy height and pre-pregnancy weight were obtained at birth had an IQ≥70 at age 10years when parents and teachers completed Child Symptom Inventory-4 questionnaires that included items about the presence of ADHD.

RESULTS: Compared to children whose mother's pre-pregnancy weight was in the normal range (BMI<25kg/m2), children were at increased risk of parent-identified ADHD behaviors if their mother was overweight (odds ratio (OR)=1.9; 95% confidence interval (CI): 1.1, 3.3), or obese (OR=2.3; 95% CI: 1.4, 3.9). They were not at increased risk of teacher-identified ADHD characteristics if their mother was overweight before her pregnancy (OR=1.0; 95% CI: 0.6, 1.8), or obese (OR=1.0; 95% CI: 0.6, 1.6).

CONCLUSION: Maternal overweight and obesity are associated with increased risk of parent-identified ADHD characteristics at 10years of age in children born extremely preterm.

Original language	English
Pages (from-to)	9-15
Number of pages	7
Journal	Early Human Development
Volume	115
Early online date	17 Aug 2017
DOIs	https://doi.org/10.1016/j.earlhumdev.2017.08.002
Publication status	Published - Dec 2017

Funding

Funders	Funder number
National Institute of Neurological Disorders and Stroke	U01NS040069
National Institute of Child Health and Human Development	5P30HD018655-34

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.earlhumdev.2017.08.002

Maternal obesity and attention-related symptoms in the preterm offspringFinal published version, 290 KBLicence: Article 25fa Dutch Copyright Act

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@article{6ed63bb46e504db182efb41bf7e31f53,

title = "Maternal obesity and attention-related symptoms in the preterm offspring",

abstract = "BACKGROUND: Maternal pre-pregnancy obesity, in term-born children, is associated with an increased risk of attention problems, however this relationship has not been explored among children born extremely preterm.AIM: To estimate the risk of attention problems at age 10years in children born very preterm to overweight (i.e., body mass index (BMI) 25-29kg/m2) and obese (i.e., BMI≥30kg/m2) women relative to the risk among children born to women who were neither overweight nor obese (i.e. BMI<25kg/m2).STUDY DESIGN: Multi-center prospective cohort study.METHODS: A total of 764 children born before the 28th week of gestation and whose mother's pre-pregnancy height and pre-pregnancy weight were obtained at birth had an IQ≥70 at age 10years when parents and teachers completed Child Symptom Inventory-4 questionnaires that included items about the presence of ADHD.RESULTS: Compared to children whose mother's pre-pregnancy weight was in the normal range (BMI<25kg/m2), children were at increased risk of parent-identified ADHD behaviors if their mother was overweight (odds ratio (OR)=1.9; 95% confidence interval (CI): 1.1, 3.3), or obese (OR=2.3; 95% CI: 1.4, 3.9). They were not at increased risk of teacher-identified ADHD characteristics if their mother was overweight before her pregnancy (OR=1.0; 95% CI: 0.6, 1.8), or obese (OR=1.0; 95% CI: 0.6, 1.6).CONCLUSION: Maternal overweight and obesity are associated with increased risk of parent-identified ADHD characteristics at 10years of age in children born extremely preterm.",

keywords = "Journal Article",

author = "{van der Burg}, {Jelske W} and Jensen, {Elizabeth T} and {van de Bor}, Margot and Joseph, {Robert M} and O'Shea, {T Michael} and Karl Kuban and Allred, {Elizabeth N} and Megan Scott and Scott Hunter and Hooper, {Stephen R} and Olaf Dammann and Alan Leviton",

note = "Copyright {\textcopyright} 2017. Published by Elsevier B.V.",

year = "2017",

month = dec,

doi = "10.1016/j.earlhumdev.2017.08.002",

language = "English",

volume = "115",

pages = "9--15",

journal = "Early Human Development",

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TY - JOUR

T1 - Maternal obesity and attention-related symptoms in the preterm offspring

AU - van der Burg, Jelske W

AU - Jensen, Elizabeth T

AU - van de Bor, Margot

AU - Joseph, Robert M

AU - O'Shea, T Michael

AU - Kuban, Karl

AU - Allred, Elizabeth N

AU - Scott, Megan

AU - Hunter, Scott

AU - Hooper, Stephen R

AU - Dammann, Olaf

AU - Leviton, Alan

PY - 2017/12

Y1 - 2017/12

N2 - BACKGROUND: Maternal pre-pregnancy obesity, in term-born children, is associated with an increased risk of attention problems, however this relationship has not been explored among children born extremely preterm.AIM: To estimate the risk of attention problems at age 10years in children born very preterm to overweight (i.e., body mass index (BMI) 25-29kg/m2) and obese (i.e., BMI≥30kg/m2) women relative to the risk among children born to women who were neither overweight nor obese (i.e. BMI<25kg/m2).STUDY DESIGN: Multi-center prospective cohort study.METHODS: A total of 764 children born before the 28th week of gestation and whose mother's pre-pregnancy height and pre-pregnancy weight were obtained at birth had an IQ≥70 at age 10years when parents and teachers completed Child Symptom Inventory-4 questionnaires that included items about the presence of ADHD.RESULTS: Compared to children whose mother's pre-pregnancy weight was in the normal range (BMI<25kg/m2), children were at increased risk of parent-identified ADHD behaviors if their mother was overweight (odds ratio (OR)=1.9; 95% confidence interval (CI): 1.1, 3.3), or obese (OR=2.3; 95% CI: 1.4, 3.9). They were not at increased risk of teacher-identified ADHD characteristics if their mother was overweight before her pregnancy (OR=1.0; 95% CI: 0.6, 1.8), or obese (OR=1.0; 95% CI: 0.6, 1.6).CONCLUSION: Maternal overweight and obesity are associated with increased risk of parent-identified ADHD characteristics at 10years of age in children born extremely preterm.

AB - BACKGROUND: Maternal pre-pregnancy obesity, in term-born children, is associated with an increased risk of attention problems, however this relationship has not been explored among children born extremely preterm.AIM: To estimate the risk of attention problems at age 10years in children born very preterm to overweight (i.e., body mass index (BMI) 25-29kg/m2) and obese (i.e., BMI≥30kg/m2) women relative to the risk among children born to women who were neither overweight nor obese (i.e. BMI<25kg/m2).STUDY DESIGN: Multi-center prospective cohort study.METHODS: A total of 764 children born before the 28th week of gestation and whose mother's pre-pregnancy height and pre-pregnancy weight were obtained at birth had an IQ≥70 at age 10years when parents and teachers completed Child Symptom Inventory-4 questionnaires that included items about the presence of ADHD.RESULTS: Compared to children whose mother's pre-pregnancy weight was in the normal range (BMI<25kg/m2), children were at increased risk of parent-identified ADHD behaviors if their mother was overweight (odds ratio (OR)=1.9; 95% confidence interval (CI): 1.1, 3.3), or obese (OR=2.3; 95% CI: 1.4, 3.9). They were not at increased risk of teacher-identified ADHD characteristics if their mother was overweight before her pregnancy (OR=1.0; 95% CI: 0.6, 1.8), or obese (OR=1.0; 95% CI: 0.6, 1.6).CONCLUSION: Maternal overweight and obesity are associated with increased risk of parent-identified ADHD characteristics at 10years of age in children born extremely preterm.

KW - Journal Article

UR - http://europepmc.org/abstract/MED/28822870

U2 - 10.1016/j.earlhumdev.2017.08.002

DO - 10.1016/j.earlhumdev.2017.08.002

M3 - Article

C2 - 28822870

SN - 0378-3782

VL - 115

SP - 9

EP - 15

JO - Early Human Development

JF - Early Human Development

ER -

Maternal obesity and attention-related symptoms in the preterm offspring

Abstract

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Keywords

UN SDGs

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