Abstract
Background: Although the EQ-5D instruments have been initially designed for adult populations, there are new studies evaluating and applying these instruments to children and adolescents. The EuroQol Group adapted and created two versions designed for these groups, i.e., the EQ-5D-Y versions. The measurement properties of the EQ-5D have been systematically reviewed in different health conditions. However, there is a lack of a proper systematic assessment including the studies’ risk of bias and focusing on recent studies assessing the EQ-5D instruments in children and adolescents. The lack of a systematic assessment of the EQ-5D versions does not allow us to have a comprehensive evaluation of the validity, reliability, and responsiveness of these instruments among children and adolescents. This systematic review aims to critically appraise and summarize the evidence on the measurement properties of the EQ-5D instruments (self-reported version – answered by children and adolescents; and proxy versions – versions reported by parents, caregivers, or health professionals) in children and adolescents. Methods: A systematic review searching the following electronic databases: MEDLINE, EMBASE, CINAHL, EconLit, National Health Service Economic Evaluation Database (NHS-EED), Health Technology Assessment (HTA) database. Two independent reviewers will screen titles and abstracts and select full texts for eligibility. The COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology will be followed to conduct three main assessment steps: risk of bias, quality criteria for measurement properties, and evidence synthesis. Discussion: This systematic review will provide comprehensive information about the evidence regarding the measurement properties of EQ-5D instruments in children and adolescents of different settings and countries. Systematic review registration: Open Science Framework with Registration https://osf.io/r8kt9/ and PROSPERO: CRD42020218382.
| Original language | English |
|---|---|
| Article number | 18 |
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Systematic Reviews |
| Volume | 13 |
| Early online date | 5 Jan 2024 |
| DOIs | |
| Publication status | Published - 2024 |
Bibliographical note
Funding Information:CMES receives a master scholarship from the Sao Paulo Research Foundation (FAPESP) – process number 2020/06864–0; VSS receives a PhD scholarship from the Sao Paulo Research Foundation (FAPESP) – process number 2019/12049–0; TPY receives a research grant from the Sao Paulo Research Foundation (FAPESP) – process number 2017/17484–1. The funding agency of this study has no influence in the design of the study and collection, analysis, and interpretation of data and in writing of the manuscript. The study has not received external funding from any funding agency in the public, commercial or not-for-profit sectors.
Publisher Copyright:
© 2024, The Author(s).
Keywords
- Children and adolescents
- EQ-5D
- Health-related quality of life
- Measurement properties