Measuring health-related quality of life in colorectal cancer patients: systematic review of measurement properties of the EORTC QLQ-CR29

Anja van der Hout, Koen I. Neijenhuijs, Femke Jansen, Cornelia F. van Uden-Kraan, Neil K. Aaronson, Mogens Groenvold, Bernhard Holzner, Caroline B. Terwee, Lonneke V. van de Poll-Franse, Pim Cuijpers, Irma M. Verdonck-de Leeuw

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

INTRODUCTION: The EORTC QLQ-CR29 is a patient-reported outcome measure to evaluate health-related quality of life among colorectal cancer patients in research and clinical practice. The aim of this systematic review was to investigate whether the initial positive results regarding the measurement properties of the QLQ-CR29 are confirmed in subsequent studies.

METHODS: A systematic search of Embase, Medline, PsycINFO, and Web of Science was conducted to identify studies investigating the measurement properties of the QLQ-CR29 published up to January 2019. For the 11 included studies, data were extracted, methodological quality was assessed, results were synthesized, and evidence was graded according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology on the measurement properties: structural validity, internal consistency, reliability, measurement error, construct validity (hypothesis testing, including known-group comparison, convergent and divergent validity), cross-cultural validity, and responsiveness.

RESULTS: Internal consistency was rated as "sufficient," with low evidence. Reliability was rated as "insufficient," with moderate evidence. Construct validity (hypothesis testing; known-group comparison, convergent and divergent validity) was rated as "inconsistent," with moderate evidence. Structural validity, measurement error, and responsiveness were rated as "indeterminate" and could therefore not be graded.

CONCLUSION: This review indicates that current evidence supporting the measurement properties of the QLQ-CR29 is limited. Additionally, better quality research is needed, taking into account the COSMIN methodology.

Original languageEnglish
Pages (from-to)2395-2412
Number of pages18
JournalSupportive Care in Cancer
Volume27
Issue number7
Early online date13 Apr 2019
DOIs
Publication statusPublished - 1 Jul 2019

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Colorectal Neoplasms
Quality of Life
Research
Health
Patient Reported Outcome Measures

Keywords

  • Colorectal cancer
  • EORTC QLQ-CR29
  • Health-related quality of life
  • Measurement property
  • Patient-reported outcome measure (PROM)
  • Systematic review

Cite this

van der Hout, Anja ; Neijenhuijs, Koen I. ; Jansen, Femke ; van Uden-Kraan, Cornelia F. ; Aaronson, Neil K. ; Groenvold, Mogens ; Holzner, Bernhard ; Terwee, Caroline B. ; van de Poll-Franse, Lonneke V. ; Cuijpers, Pim ; Verdonck-de Leeuw, Irma M. / Measuring health-related quality of life in colorectal cancer patients : systematic review of measurement properties of the EORTC QLQ-CR29. In: Supportive Care in Cancer. 2019 ; Vol. 27, No. 7. pp. 2395-2412.
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abstract = "INTRODUCTION: The EORTC QLQ-CR29 is a patient-reported outcome measure to evaluate health-related quality of life among colorectal cancer patients in research and clinical practice. The aim of this systematic review was to investigate whether the initial positive results regarding the measurement properties of the QLQ-CR29 are confirmed in subsequent studies.METHODS: A systematic search of Embase, Medline, PsycINFO, and Web of Science was conducted to identify studies investigating the measurement properties of the QLQ-CR29 published up to January 2019. For the 11 included studies, data were extracted, methodological quality was assessed, results were synthesized, and evidence was graded according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology on the measurement properties: structural validity, internal consistency, reliability, measurement error, construct validity (hypothesis testing, including known-group comparison, convergent and divergent validity), cross-cultural validity, and responsiveness.RESULTS: Internal consistency was rated as {"}sufficient,{"} with low evidence. Reliability was rated as {"}insufficient,{"} with moderate evidence. Construct validity (hypothesis testing; known-group comparison, convergent and divergent validity) was rated as {"}inconsistent,{"} with moderate evidence. Structural validity, measurement error, and responsiveness were rated as {"}indeterminate{"} and could therefore not be graded.CONCLUSION: This review indicates that current evidence supporting the measurement properties of the QLQ-CR29 is limited. Additionally, better quality research is needed, taking into account the COSMIN methodology.",
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Measuring health-related quality of life in colorectal cancer patients : systematic review of measurement properties of the EORTC QLQ-CR29. / van der Hout, Anja; Neijenhuijs, Koen I.; Jansen, Femke; van Uden-Kraan, Cornelia F.; Aaronson, Neil K.; Groenvold, Mogens; Holzner, Bernhard; Terwee, Caroline B.; van de Poll-Franse, Lonneke V.; Cuijpers, Pim; Verdonck-de Leeuw, Irma M.

In: Supportive Care in Cancer, Vol. 27, No. 7, 01.07.2019, p. 2395-2412.

Research output: Contribution to JournalReview articleAcademicpeer-review

TY - JOUR

T1 - Measuring health-related quality of life in colorectal cancer patients

T2 - systematic review of measurement properties of the EORTC QLQ-CR29

AU - van der Hout, Anja

AU - Neijenhuijs, Koen I.

AU - Jansen, Femke

AU - van Uden-Kraan, Cornelia F.

AU - Aaronson, Neil K.

AU - Groenvold, Mogens

AU - Holzner, Bernhard

AU - Terwee, Caroline B.

AU - van de Poll-Franse, Lonneke V.

AU - Cuijpers, Pim

AU - Verdonck-de Leeuw, Irma M.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - INTRODUCTION: The EORTC QLQ-CR29 is a patient-reported outcome measure to evaluate health-related quality of life among colorectal cancer patients in research and clinical practice. The aim of this systematic review was to investigate whether the initial positive results regarding the measurement properties of the QLQ-CR29 are confirmed in subsequent studies.METHODS: A systematic search of Embase, Medline, PsycINFO, and Web of Science was conducted to identify studies investigating the measurement properties of the QLQ-CR29 published up to January 2019. For the 11 included studies, data were extracted, methodological quality was assessed, results were synthesized, and evidence was graded according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology on the measurement properties: structural validity, internal consistency, reliability, measurement error, construct validity (hypothesis testing, including known-group comparison, convergent and divergent validity), cross-cultural validity, and responsiveness.RESULTS: Internal consistency was rated as "sufficient," with low evidence. Reliability was rated as "insufficient," with moderate evidence. Construct validity (hypothesis testing; known-group comparison, convergent and divergent validity) was rated as "inconsistent," with moderate evidence. Structural validity, measurement error, and responsiveness were rated as "indeterminate" and could therefore not be graded.CONCLUSION: This review indicates that current evidence supporting the measurement properties of the QLQ-CR29 is limited. Additionally, better quality research is needed, taking into account the COSMIN methodology.

AB - INTRODUCTION: The EORTC QLQ-CR29 is a patient-reported outcome measure to evaluate health-related quality of life among colorectal cancer patients in research and clinical practice. The aim of this systematic review was to investigate whether the initial positive results regarding the measurement properties of the QLQ-CR29 are confirmed in subsequent studies.METHODS: A systematic search of Embase, Medline, PsycINFO, and Web of Science was conducted to identify studies investigating the measurement properties of the QLQ-CR29 published up to January 2019. For the 11 included studies, data were extracted, methodological quality was assessed, results were synthesized, and evidence was graded according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology on the measurement properties: structural validity, internal consistency, reliability, measurement error, construct validity (hypothesis testing, including known-group comparison, convergent and divergent validity), cross-cultural validity, and responsiveness.RESULTS: Internal consistency was rated as "sufficient," with low evidence. Reliability was rated as "insufficient," with moderate evidence. Construct validity (hypothesis testing; known-group comparison, convergent and divergent validity) was rated as "inconsistent," with moderate evidence. Structural validity, measurement error, and responsiveness were rated as "indeterminate" and could therefore not be graded.CONCLUSION: This review indicates that current evidence supporting the measurement properties of the QLQ-CR29 is limited. Additionally, better quality research is needed, taking into account the COSMIN methodology.

KW - Colorectal cancer

KW - EORTC QLQ-CR29

KW - Health-related quality of life

KW - Measurement property

KW - Patient-reported outcome measure (PROM)

KW - Systematic review

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DO - 10.1007/s00520-019-04764-7

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JO - Supportive Care in Cancer

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SN - 0941-4355

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