Mechanical loading stimulates BMP7, but not BMP2, production by osteocytes

A. Santos, A.D. Bakker, H.M.E. Willems, N. Bravenboer, A.L.J.J. Bronckers, J. Klein-Nulend

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    Bone mechanical adaptation is a cellular process that allows bones to adapt their mass and structure to mechanical loading. This process is governed by the osteocytes, which in response to mechanical loading produce signaling molecules that affect osteoblasts and osteoclasts. Bone morphogenic proteins (BMPs) are excellent candidates as signaling molecules, but it is unknown whether mechanically stimulated osteocytes affect bone adaptation through BMP production. Therefore, the aim of this study was to assess whether osteocytes produce BMPs in response to mechanical loading. In addition, since BMP7 has a vitamin D receptor (VDR) response element in the promoter region, we also investigated whether VDR is involved in the BMP7 response to mechanical loading. Human or VDR
    Original languageEnglish
    Pages (from-to)318-326
    JournalCalcified Tissue International
    Volume89
    Issue number4
    DOIs
    Publication statusPublished - 2011

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    Osteocytes
    Bone and Bones
    Calcitriol Receptors
    Vitamin D Response Element
    Proteins
    Osteoclasts
    Osteoblasts
    Genetic Promoter Regions

    Cite this

    Santos, A., Bakker, A. D., Willems, H. M. E., Bravenboer, N., Bronckers, A. L. J. J., & Klein-Nulend, J. (2011). Mechanical loading stimulates BMP7, but not BMP2, production by osteocytes. Calcified Tissue International, 89(4), 318-326. https://doi.org/10.1007/s00223-011-9521-1
    Santos, A. ; Bakker, A.D. ; Willems, H.M.E. ; Bravenboer, N. ; Bronckers, A.L.J.J. ; Klein-Nulend, J. / Mechanical loading stimulates BMP7, but not BMP2, production by osteocytes. In: Calcified Tissue International. 2011 ; Vol. 89, No. 4. pp. 318-326.
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    abstract = "Bone mechanical adaptation is a cellular process that allows bones to adapt their mass and structure to mechanical loading. This process is governed by the osteocytes, which in response to mechanical loading produce signaling molecules that affect osteoblasts and osteoclasts. Bone morphogenic proteins (BMPs) are excellent candidates as signaling molecules, but it is unknown whether mechanically stimulated osteocytes affect bone adaptation through BMP production. Therefore, the aim of this study was to assess whether osteocytes produce BMPs in response to mechanical loading. In addition, since BMP7 has a vitamin D receptor (VDR) response element in the promoter region, we also investigated whether VDR is involved in the BMP7 response to mechanical loading. Human or VDR",
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    Santos, A, Bakker, AD, Willems, HME, Bravenboer, N, Bronckers, ALJJ & Klein-Nulend, J 2011, 'Mechanical loading stimulates BMP7, but not BMP2, production by osteocytes' Calcified Tissue International, vol. 89, no. 4, pp. 318-326. https://doi.org/10.1007/s00223-011-9521-1

    Mechanical loading stimulates BMP7, but not BMP2, production by osteocytes. / Santos, A.; Bakker, A.D.; Willems, H.M.E.; Bravenboer, N.; Bronckers, A.L.J.J.; Klein-Nulend, J.

    In: Calcified Tissue International, Vol. 89, No. 4, 2011, p. 318-326.

    Research output: Contribution to JournalArticleAcademicpeer-review

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    AU - Bakker, A.D.

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    AU - Bronckers, A.L.J.J.

    AU - Klein-Nulend, J.

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    AB - Bone mechanical adaptation is a cellular process that allows bones to adapt their mass and structure to mechanical loading. This process is governed by the osteocytes, which in response to mechanical loading produce signaling molecules that affect osteoblasts and osteoclasts. Bone morphogenic proteins (BMPs) are excellent candidates as signaling molecules, but it is unknown whether mechanically stimulated osteocytes affect bone adaptation through BMP production. Therefore, the aim of this study was to assess whether osteocytes produce BMPs in response to mechanical loading. In addition, since BMP7 has a vitamin D receptor (VDR) response element in the promoter region, we also investigated whether VDR is involved in the BMP7 response to mechanical loading. Human or VDR

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    Santos A, Bakker AD, Willems HME, Bravenboer N, Bronckers ALJJ, Klein-Nulend J. Mechanical loading stimulates BMP7, but not BMP2, production by osteocytes. Calcified Tissue International. 2011;89(4):318-326. https://doi.org/10.1007/s00223-011-9521-1