Mechanism of adolescent depression and Non-Suicidal Self-Injury: Interaction between interpersonal relationship and the OXTR gene

Zihao Zeng, Shan Ding, Shuangjin Liu, Hongcai Wang, Qin Yang, Yiqiu Hu*, Yong Liu*

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background: Based on ecosystem theory and genetic and environmental research paradigms, the current research explored the influence mechanism of interpersonal relationship and OXTR gene rs1042778, rs2254298 and rs53576 polymorphisms on adolescent depression and NSSI. Method: The main study investigation explored the effect of the interaction between interpersonal relationship and OXTR gene on adolescent depression and Non-Suicidal Self-Injury (NSSI). Concurrently, a supplementary examination investigated oxytocin's physiological impact on the social-emotional behaviors of mice subjected to post-weaning social isolation. Results: OXTR gene rs2254298 and rs53576 moderated the influence of interpersonal relationship on adolescent depression, and rs2254298 also moderated the influence of interpersonal relationship on adolescent NSSI. PWSI reduced the mice's emotional social ability and affected the expression and transcription of OXT and OXTR mRNA, which could be reversed after an appropriate dose of oxytocin treatment. Conclusion: Interaction between interpersonal relationship and the OXTR gene affects adolescent depression and NSSI. The OXTR gene heterozygous genotype individuals were more sensitive to environmental stimuli, supporting the differential susceptibility model.

Original languageEnglish
Pages (from-to)66-73
Number of pages8
JournalJournal of Psychiatric Research
Volume182
Early online date3 Jan 2025
DOIs
Publication statusPublished - Feb 2025

Bibliographical note

Publisher Copyright:
© 2024

Keywords

  • Adolescent depression
  • Adolescent NSSI
  • Interpersonal relationship
  • Oxytocin receptor gene

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