TY - JOUR
T1 - Mechanisms of osteocyte mechanotransduction
AU - Bakker, A.D.
AU - Klein-Nulend, J.
N1 - Published online: 14 January 2011
PY - 2010/12
Y1 - 2010/12
N2 - Healthy bones combine a proper resistance against fracture with a minimum use of material. This property is likely brought about by osteocytes in response to mechanical cues, but it is still unknown how whole bone loads are translated into a signal that can be sensed by the osteocytes. The goal of this chapter is to critically analyze our current knowledge on how bone transduction takes place from the level of mechanical loads placed upon the bone as an organ to activation of a cell.
AB - Healthy bones combine a proper resistance against fracture with a minimum use of material. This property is likely brought about by osteocytes in response to mechanical cues, but it is still unknown how whole bone loads are translated into a signal that can be sensed by the osteocytes. The goal of this chapter is to critically analyze our current knowledge on how bone transduction takes place from the level of mechanical loads placed upon the bone as an organ to activation of a cell.
UR - https://www.scopus.com/pages/publications/79960134365
UR - https://www.scopus.com/inward/citedby.url?scp=79960134365&partnerID=8YFLogxK
U2 - 10.1007/s12018-010-9079-x
DO - 10.1007/s12018-010-9079-x
M3 - Article
SN - 1534-8644
VL - 8
SP - 163
EP - 169
JO - Clinical Reviews in Bone and Mineral Metabolism
JF - Clinical Reviews in Bone and Mineral Metabolism
ER -