TY - JOUR
T1 - MEG resting state functional connectivity in Parkinson's disease related dementia
AU - Bosboom, J.L.W.
AU - Stoffers, D.
AU - Wolters, E.C.
AU - Stam, C.J.
AU - Berendse, H.W.
N1 - J English Article Bosboom, JLW, Vrije Univ Amsterdam, Med Ctr, Dept Neurol, POB 7057, NL-1007 MB Amsterdam, Netherlands [email protected] 54 0 SPRINGER WIEN WIEN SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA J NEURAL TRANSM FEB Discipline: Clinical Neurology; Neurosciences 494OT
PY - 2009
Y1 - 2009
N2 - Parkinson's disease (PD) related dementia (PDD) develops in up to 60% of patients, but the pathophysiology is far from being elucidated. Abnormalities of resting state functional connectivity have been reported in Alzheimer's disease (AD). The present study was performed to determine whether PDD is likewise characterized by changes in resting state functional connectivity. MEG recordings were obtained in 13 demented and 13 non-demented PD patients. The synchronization likelihood (SL) was calculated within and between cortical areas in six frequency bands. Compared to non-demented PD, PDD was characterized by lower fronto-temporal SL in the alpha range, lower intertemporal SL in delta, theta and alpha1 bands as well as decreased centro-parietal gamma band synchronization. In addition, higher parieto-occipital synchronization in the alpha2 and beta bands was found in PDD. The observed changes in functional connectivity are reminiscent of changes in AD, and may reflect reduced cholinergic activity and/or loss of cortico-cortical anatomical connections in PDD. © 2008 The Author(s).
AB - Parkinson's disease (PD) related dementia (PDD) develops in up to 60% of patients, but the pathophysiology is far from being elucidated. Abnormalities of resting state functional connectivity have been reported in Alzheimer's disease (AD). The present study was performed to determine whether PDD is likewise characterized by changes in resting state functional connectivity. MEG recordings were obtained in 13 demented and 13 non-demented PD patients. The synchronization likelihood (SL) was calculated within and between cortical areas in six frequency bands. Compared to non-demented PD, PDD was characterized by lower fronto-temporal SL in the alpha range, lower intertemporal SL in delta, theta and alpha1 bands as well as decreased centro-parietal gamma band synchronization. In addition, higher parieto-occipital synchronization in the alpha2 and beta bands was found in PDD. The observed changes in functional connectivity are reminiscent of changes in AD, and may reflect reduced cholinergic activity and/or loss of cortico-cortical anatomical connections in PDD. © 2008 The Author(s).
U2 - 10.1007/s00702-008-0132-6
DO - 10.1007/s00702-008-0132-6
M3 - Article
SN - 0300-9564
VL - 116
SP - 193
EP - 202
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 2
ER -
