Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

P. Gormley, V. Anttila, B.S. Winsvold, P. Palta, T. Esko, T.H. Pers, K.H. Farh, E. Cuenca-Leon, M. Muona, N.A. Furlotte, T. Kurth, A. Ingason, G. McMahon, L. Ligthart, G.M. Terwindt, M. Kallela, T. Freilinger, C. Ran, S.G. Gordon, A.H. StamS. Steinberg, G. Borck, M. Koiranen, L. Quaye, H.H.H. Adams, T. Lehtimäki, A.P. Sarin, J. Wedenoja, D.A. Hinds, J.E. Buring, M. Schürks, P.M. Ridker, M. Gudlaug Hrafnsdottir, H. Stefansson, S.M. Ring, J.J. Hottenga, B.W.J.H. Penninx, M. Färkkilä, V. Artto, M.A. Kaunisto, S. Vepsäläinen, R. Malik, A.C. Heath, P.A.F. Madden, N.G. Martin, G.W. Montgomery, M.I. Kurki, M. Kals, R. Mägi, K. Pärn, E. Hämaläinen, H. Huang, A.E. Byrnes, L. Franke, J. Huang, E. Stergiakouli, P.H. Lee, C. Sandor, C. Webber, Z. Cader, B. Müller-Myhsok, S Schreiber, T. Meitinger, J.G. Eriksson, V. Salomaa, K. Heikkilä, A.G. Loehrer, A.G. Uitterlinden, A. Hofman, C.M. van Duijn, L. Cherkas, L. Pedersen, A. Stubhaug, C.S. Nielsen, M. Männikkö, E. Mihailov, L. Milani, H. Göbel, A.L. Esserlind, A. Francke Christensen, T. Folkmann Hansen, T. Werge, J. Kaprio, A. Aromaa, O. Raitakari, M.A. Ikram, T.D. Spector, M.R. Järvelin, A. Metspalu, C. Kubisch, D.P. Strachan, M.D. Ferrari, A.C. Belin, M. Dichgans, M. Wessman, A.M.J.M. van den Maagdenberg, J.A. Zwart, D.I. Boomsma, G. Davey Smith, K. Stefansson, N. Eriksson, M.J. Daly, B.M. Neale, J. Olesen, D.I. Chasman, DR Nyholt, A. Palotie, D. Posthuma

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Abstract

Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10
Original languageEnglish
Pages (from-to)856-866
JournalNature Genetics
Volume48
Issue number8
DOIs
Publication statusPublished - 2016

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Gormley, P., Anttila, V., Winsvold, B. S., Palta, P., Esko, T., Pers, T. H., ... Posthuma, D. (2016). Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48(8), 856-866. https://doi.org/10.1038/ng.3598