Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

P. Gormley; V. Anttila; B.S. Winsvold; P. Palta; T. Esko; T.H. Pers; K.H. Farh; E. Cuenca-Leon; M. Muona; N.A. Furlotte; T. Kurth; A. Ingason; G. McMahon; L. Ligthart; G.M. Terwindt; M. Kallela; T. Freilinger; C. Ran; S.G. Gordon; A.H. Stam; S. Steinberg; G. Borck; M. Koiranen; L. Quaye; H.H.H. Adams; T. Lehtimäki; A.P. Sarin; J. Wedenoja; D.A. Hinds; J.E. Buring; M. Schürks; P.M. Ridker; M. Gudlaug Hrafnsdottir; H. Stefansson; S.M. Ring; J.J. Hottenga; B.W.J.H. Penninx; M. Färkkilä; V. Artto; M.A. Kaunisto; S. Vepsäläinen; R. Malik; A.C. Heath; P.A.F. Madden; N.G. Martin; G.W. Montgomery; M.I. Kurki; M. Kals; R. Mägi; K. Pärn; E. Hämaläinen; H. Huang; A.E. Byrnes; L. Franke; J. Huang; E. Stergiakouli; P.H. Lee; C. Sandor; C. Webber; Z. Cader; B. Müller-Myhsok; S Schreiber; T. Meitinger; J.G. Eriksson; V. Salomaa; K. Heikkilä; A.G. Loehrer; A.G. Uitterlinden; A. Hofman; C.M. van Duijn; L. Cherkas; L. Pedersen; A. Stubhaug; C.S. Nielsen; M. Männikkö; E. Mihailov; L. Milani; H. Göbel; A.L. Esserlind; A. Francke Christensen; T. Folkmann Hansen; T. Werge; J. Kaprio; A. Aromaa; O. Raitakari; M.A. Ikram; T.D. Spector; M.R. Järvelin; A. Metspalu; C. Kubisch; D.P. Strachan; M.D. Ferrari; A.C. Belin; M. Dichgans; M. Wessman; A.M.J.M. van den Maagdenberg; J.A. Zwart; D.I. Boomsma; G. Davey Smith; K. Stefansson; N. Eriksson; M.J. Daly; B.M. Neale; J. Olesen; D.I. Chasman; DR Nyholt; A. Palotie; D. Posthuma

doi:10.1038/ng.3598

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

P. Gormley, V. Anttila, B.S. Winsvold, P. Palta, T. Esko, T.H. Pers, K.H. Farh, E. Cuenca-Leon, M. Muona, N.A. Furlotte, T. Kurth, A. Ingason, G. McMahon, L. Ligthart, G.M. Terwindt, M. Kallela, T. Freilinger, C. Ran, S.G. Gordon, A.H. StamS. Steinberg, G. Borck, M. Koiranen, L. Quaye, H.H.H. Adams, T. Lehtimäki, A.P. Sarin, J. Wedenoja, D.A. Hinds, J.E. Buring, M. Schürks, P.M. Ridker, M. Gudlaug Hrafnsdottir, H. Stefansson, S.M. Ring, J.J. Hottenga, B.W.J.H. Penninx, M. Färkkilä, V. Artto, M.A. Kaunisto, S. Vepsäläinen, R. Malik, A.C. Heath, P.A.F. Madden, N.G. Martin, G.W. Montgomery, M.I. Kurki, M. Kals, R. Mägi, K. Pärn, E. Hämaläinen, H. Huang, A.E. Byrnes, L. Franke, J. Huang, E. Stergiakouli, P.H. Lee, C. Sandor, C. Webber, Z. Cader, B. Müller-Myhsok, S Schreiber, T. Meitinger, J.G. Eriksson, V. Salomaa, K. Heikkilä, A.G. Loehrer, A.G. Uitterlinden, A. Hofman, C.M. van Duijn, L. Cherkas, L. Pedersen, A. Stubhaug, C.S. Nielsen, M. Männikkö, E. Mihailov, L. Milani, H. Göbel, A.L. Esserlind, A. Francke Christensen, T. Folkmann Hansen, T. Werge, J. Kaprio, A. Aromaa, O. Raitakari, M.A. Ikram, T.D. Spector, M.R. Järvelin, A. Metspalu, C. Kubisch, D.P. Strachan, M.D. Ferrari, A.C. Belin, M. Dichgans, M. Wessman, A.M.J.M. van den Maagdenberg, J.A. Zwart, D.I. Boomsma, G. Davey Smith, K. Stefansson, N. Eriksson, M.J. Daly, B.M. Neale, J. Olesen, D.I. Chasman, DR Nyholt, A. Palotie, D. Posthuma

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10

Original language	English
Pages (from-to)	856-866
Journal	Nature Genetics
Volume	48
Issue number	8
DOIs	https://doi.org/10.1038/ng.3598
Publication status	Published - 2016

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Gormley, P., Anttila, V., Winsvold, B. S., Palta, P., Esko, T., Pers, T. H., Farh, K. H., Cuenca-Leon, E., Muona, M., Furlotte, N. A., Kurth, T., Ingason, A., McMahon, G., Ligthart, L., Terwindt, G. M., Kallela, M., Freilinger, T., Ran, C., Gordon, S. G., ... Posthuma, D. (2016). Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48(8), 856-866. https://doi.org/10.1038/ng.3598

@article{f9fb19dfce584c0cae8b3191df0f1267,

title = "Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine",

abstract = "Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10",

author = "P. Gormley and V. Anttila and B.S. Winsvold and P. Palta and T. Esko and T.H. Pers and K.H. Farh and E. Cuenca-Leon and M. Muona and N.A. Furlotte and T. Kurth and A. Ingason and G. McMahon and L. Ligthart and G.M. Terwindt and M. Kallela and T. Freilinger and C. Ran and S.G. Gordon and A.H. Stam and S. Steinberg and G. Borck and M. Koiranen and L. Quaye and H.H.H. Adams and T. Lehtim{\"a}ki and A.P. Sarin and J. Wedenoja and D.A. Hinds and J.E. Buring and M. Sch{\"u}rks and P.M. Ridker and {Gudlaug Hrafnsdottir}, M. and H. Stefansson and S.M. Ring and J.J. Hottenga and B.W.J.H. Penninx and M. F{\"a}rkkil{\"a} and V. Artto and M.A. Kaunisto and S. Veps{\"a}l{\"a}inen and R. Malik and A.C. Heath and P.A.F. Madden and N.G. Martin and G.W. Montgomery and M.I. Kurki and M. Kals and R. M{\"a}gi and K. P{\"a}rn and E. H{\"a}mal{\"a}inen and H. Huang and A.E. Byrnes and L. Franke and J. Huang and E. Stergiakouli and P.H. Lee and C. Sandor and C. Webber and Z. Cader and B. M{\"u}ller-Myhsok and S Schreiber and T. Meitinger and J.G. Eriksson and V. Salomaa and K. Heikkil{\"a} and A.G. Loehrer and A.G. Uitterlinden and A. Hofman and {van Duijn}, C.M. and L. Cherkas and L. Pedersen and A. Stubhaug and C.S. Nielsen and M. M{\"a}nnikk{\"o} and E. Mihailov and L. Milani and H. G{\"o}bel and A.L. Esserlind and {Francke Christensen}, A. and {Folkmann Hansen}, T. and T. Werge and J. Kaprio and A. Aromaa and O. Raitakari and M.A. Ikram and T.D. Spector and M.R. J{\"a}rvelin and A. Metspalu and C. Kubisch and D.P. Strachan and M.D. Ferrari and A.C. Belin and M. Dichgans and M. Wessman and {van den Maagdenberg}, A.M.J.M. and J.A. Zwart and D.I. Boomsma and {Davey Smith}, G. and K. Stefansson and N. Eriksson and M.J. Daly and B.M. Neale and J. Olesen and D.I. Chasman and DR Nyholt and A. Palotie and D. Posthuma",

year = "2016",

doi = "10.1038/ng.3598",

language = "English",

volume = "48",

pages = "856--866",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "8",

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Gormley, P, Anttila, V, Winsvold, BS, Palta, P, Esko, T, Pers, TH, Farh, KH, Cuenca-Leon, E, Muona, M, Furlotte, NA, Kurth, T, Ingason, A, McMahon, G, Ligthart, L, Terwindt, GM, Kallela, M, Freilinger, T, Ran, C, Gordon, SG, Stam, AH, Steinberg, S, Borck, G, Koiranen, M, Quaye, L, Adams, HHH, Lehtimäki, T, Sarin, AP, Wedenoja, J, Hinds, DA, Buring, JE, Schürks, M, Ridker, PM, Gudlaug Hrafnsdottir, M, Stefansson, H, Ring, SM, Hottenga, JJ, Penninx, BWJH, Färkkilä, M, Artto, V, Kaunisto, MA, Vepsäläinen, S, Malik, R, Heath, AC, Madden, PAF, Martin, NG, Montgomery, GW, Kurki, MI, Kals, M, Mägi, R, Pärn, K, Hämaläinen, E, Huang, H, Byrnes, AE, Franke, L, Huang, J, Stergiakouli, E, Lee, PH, Sandor, C, Webber, C, Cader, Z, Müller-Myhsok, B, Schreiber, S, Meitinger, T, Eriksson, JG, Salomaa, V, Heikkilä, K, Loehrer, AG, Uitterlinden, AG, Hofman, A, van Duijn, CM, Cherkas, L, Pedersen, L, Stubhaug, A, Nielsen, CS, Männikkö, M, Mihailov, E, Milani, L, Göbel, H, Esserlind, AL, Francke Christensen, A, Folkmann Hansen, T, Werge, T, Kaprio, J, Aromaa, A, Raitakari, O, Ikram, MA, Spector, TD, Järvelin, MR, Metspalu, A, Kubisch, C, Strachan, DP, Ferrari, MD, Belin, AC, Dichgans, M, Wessman, M, van den Maagdenberg, AMJM, Zwart, JA, Boomsma, DI, Davey Smith, G, Stefansson, K, Eriksson, N, Daly, MJ, Neale, BM, Olesen, J, Chasman, DI, Nyholt, DR, Palotie, A & Posthuma, D 2016, 'Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine', Nature Genetics, vol. 48, no. 8, pp. 856-866. https://doi.org/10.1038/ng.3598

TY - JOUR

T1 - Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

AU - Gormley, P.

AU - Anttila, V.

AU - Winsvold, B.S.

AU - Palta, P.

AU - Esko, T.

AU - Pers, T.H.

AU - Farh, K.H.

AU - Cuenca-Leon, E.

AU - Muona, M.

AU - Furlotte, N.A.

AU - Kurth, T.

AU - Ingason, A.

AU - McMahon, G.

AU - Ligthart, L.

AU - Terwindt, G.M.

AU - Kallela, M.

AU - Freilinger, T.

AU - Ran, C.

AU - Gordon, S.G.

AU - Stam, A.H.

AU - Steinberg, S.

AU - Borck, G.

AU - Koiranen, M.

AU - Quaye, L.

AU - Adams, H.H.H.

AU - Lehtimäki, T.

AU - Sarin, A.P.

AU - Wedenoja, J.

AU - Hinds, D.A.

AU - Buring, J.E.

AU - Schürks, M.

AU - Ridker, P.M.

AU - Gudlaug Hrafnsdottir, M.

AU - Stefansson, H.

AU - Ring, S.M.

AU - Hottenga, J.J.

AU - Penninx, B.W.J.H.

AU - Färkkilä, M.

AU - Artto, V.

AU - Kaunisto, M.A.

AU - Vepsäläinen, S.

AU - Malik, R.

AU - Heath, A.C.

AU - Madden, P.A.F.

AU - Martin, N.G.

AU - Montgomery, G.W.

AU - Kurki, M.I.

AU - Kals, M.

AU - Mägi, R.

AU - Pärn, K.

AU - Hämaläinen, E.

AU - Huang, H.

AU - Byrnes, A.E.

AU - Franke, L.

AU - Huang, J.

AU - Stergiakouli, E.

AU - Lee, P.H.

AU - Sandor, C.

AU - Webber, C.

AU - Cader, Z.

AU - Müller-Myhsok, B.

AU - Schreiber, S

AU - Meitinger, T.

AU - Eriksson, J.G.

AU - Salomaa, V.

AU - Heikkilä, K.

AU - Loehrer, A.G.

AU - Uitterlinden, A.G.

AU - Hofman, A.

AU - van Duijn, C.M.

AU - Cherkas, L.

AU - Pedersen, L.

AU - Stubhaug, A.

AU - Nielsen, C.S.

AU - Männikkö, M.

AU - Mihailov, E.

AU - Milani, L.

AU - Göbel, H.

AU - Esserlind, A.L.

AU - Francke Christensen, A.

AU - Folkmann Hansen, T.

AU - Werge, T.

AU - Kaprio, J.

AU - Aromaa, A.

AU - Raitakari, O.

AU - Ikram, M.A.

AU - Spector, T.D.

AU - Järvelin, M.R.

AU - Metspalu, A.

AU - Kubisch, C.

AU - Strachan, D.P.

AU - Ferrari, M.D.

AU - Belin, A.C.

AU - Dichgans, M.

AU - Wessman, M.

AU - van den Maagdenberg, A.M.J.M.

AU - Zwart, J.A.

AU - Boomsma, D.I.

AU - Davey Smith, G.

AU - Stefansson, K.

AU - Eriksson, N.

AU - Daly, M.J.

AU - Neale, B.M.

AU - Olesen, J.

AU - Chasman, D.I.

AU - Nyholt, DR

AU - Palotie, A.

AU - Posthuma, D.

PY - 2016

Y1 - 2016

N2 - Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10

AB - Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10

U2 - 10.1038/ng.3598

DO - 10.1038/ng.3598

M3 - Article

SN - 1061-4036

VL - 48

SP - 856

EP - 866

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Abstract

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UN SDGs

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