@article{a39794886dc94122a11f58fbb9750a8a,
title = "Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight",
abstract = "Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10-7). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10-74) and BMI in pregnancy (3/914, p = 1.13x10-3), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.",
author = "K{\"u}pers, {Leanne K.} and Claire Monnereau and Sharp, {Gemma C.} and Paul Yousefi and Salas, {Lucas A.} and Akram Ghantous and Page, {Christian M.} and Reese, {Sarah E.} and Wilcox, {Allen J.} and Darina Czamara and Starling, {Anne P.} and Alexei Novoloaca and Samantha Lent and Ritu Roy and Cathrine Hoyo and Breton, {Carrie V.} and Catherine Allard and Just, {Allan C.} and Bakulski, {Kelly M.} and Holloway, {John W.} and Everson, {Todd M.} and Xu, {Cheng Jian} and Huang, {Rae Chi} and {van der Plaat}, {Diana A.} and Matthias Wielscher and Merid, {Simon Kebede} and Vilhelmina Ullemar and Rezwan, {Faisal I.} and Jari Lahti and {van Dongen}, Jenny and Langie, {Sabine A.S.} and Richardson, {Tom G.} and Magnus, {Maria C.} and Nohr, {Ellen A.} and Zongli Xu and Liesbeth Duijts and Shanshan Zhao and Weiming Zhang and Michelle Plusquin and DeMeo, {Dawn L.} and Olivia Solomon and Heimovaara, {Joosje H.} and Jima, {Dereje D.} and Lu Gao and Mariona Bustamante and Patrice Perron and Wright, {Robert O.} and Irva Hertz-Picciotto and Hongmei Zhang and Karagas, {Margaret R.} and Ulrike Gehring and Marsit, {Carmen J.} and Beilin, {Lawrence J.} and Vonk, {Judith M.} and Jarvelin, {Marjo Riitta} and Anna Bergstr{\"o}m and {\"O}rtqvist, {Anne K.} and Susan Ewart and Villa, {Pia M.} and Moore, {Sophie E.} and Gonneke Willemsen and Standaert, {Arnout R.L.} and H{\aa}berg, {Siri E.} and S{\o}rensen, {Thorkild I.A.} and Taylor, {Jack A.} and Katri R{\"a}ikk{\"o}nen and Yang, {Ivana V.} and Katerina Kechris and Nawrot, {Tim S.} and Silver, {Matt J.} and Gong, {Yun Yun} and Lorenzo Richiardi and Manolis Kogevinas and Litonjua, {Augusto A.} and Brenda Eskenazi and Karen Huen and Hamdi Mbarek and Maguire, {Rachel L.} and Terence Dwyer and Martine Vrijheid and Luigi Bouchard and Baccarelli, {Andrea A.} and Croen, {Lisa A.} and Wilfried Karmaus and Denise Anderson and {de Vries}, Maaike and Sylvain Sebert and Juha Kere and Robert Karlsson and Arshad, {Syed Hasan} and Esa H{\"a}m{\"a}l{\"a}inen and Routledge, {Michael N.} and Boomsma, {Dorret I.} and Feinberg, {Andrew P.} and Newschaffer, {Craig J.} and Eva Govarts and Matthieu Moisse and Fallin, {M. Daniele} and Erik Mel{\'e}n and Prentice, {Andrew M.} and Eero Kajantie and Catarina Almqvist and Emily Oken and Dana Dabelea and Boezen, {H. Marike} and Melton, {Phillip E.} and Wright, {Rosalind J.} and Koppelman, {Gerard H.} and Letizia Trevisi and Hivert, {Marie France} and Jordi Sunyer and Munthe-Kaas, {Monica C.} and Murphy, {Susan K.} and Eva Corpeleijn and Joseph Wiemels and Nina Holland and Zdenko Herceg and Binder, {Elisabeth B.} and {Davey Smith}, George and Jaddoe, {Vincent W.V.} and Lie, {Rolv T.} and Wenche Nystad and London, {Stephanie J.} and Lawlor, {Debbie A.} and Relton, {Caroline L.} and Harold Snieder and Felix, {Janine F.} and {Pregnancy And Childhood Epigenetics Consortium}",
year = "2019",
month = apr,
day = "23",
doi = "10.1038/s41467-019-09671-3",
language = "English",
volume = "10",
pages = "1--11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
}
