Meta-analysis of genome-wide association studies for personality

M.H.M. de Moor, P.T. Costa, A. Terracciano, R.F. Krueger, E.J.C. de Geus, T. Toshiko, B.W.J.H. Penninx, T. Esko, P.A.F. Madden, J. Derringer, N. Amin, G. Willemsen, J.J. Hottenga, M.A. Distel, M. Uda, S. Sanna, P. Spinhoven, C.A. Hartman, P.F. Sullivan, A. RealoJ. Allik, A.C. Heath, M.L. Pergadia, A. Agrawal, P. Lin, R.A. Grucza, T. Nutile, M. Ciullo, D. Rujescu, I. Giegling, B. Konte, E. Widen, D.L. Cousminer, J.G. Eriksson, A. Palotie, L. Peltonen, M Luciano, A. Tenesa, G. Davies, L.M. Lopez, N.K. Hansell, S.E. Medland, L. Ferrucci, D. Schlessinger, G.W. Montgomery, M.J. Wright, Y.S. Aulchenko, A.C.J.W. Janssens, B.A. Oostra, A. Metspalu, G.R. Abecasis, I.J. Deary, K. Räikkönen, L.J. Bierut, N.G. Martin, C.M. van Duijn, D.I. Boomsma

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Abstract

Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17 375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness were based on the NEO Five-Factor Inventory. Genotype data of ∼2.4M single-nucleotide polymorphisms (SNPs; directly typed and imputed using HapMap data) were available. In the discovery samples, classical association analyses were performed under an additive model followed by meta-analysis using the weighted inverse variance method. Results showed genome-wide significance for Openness to Experience near the RASA1 gene on 5q14.3 (rs1477268 and rs2032794, P2.8 × 10
Original languageEnglish
Pages (from-to)337-349
JournalMolecular Psychiatry
Volume17
Issue number3
DOIs
Publication statusPublished - 2012

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