Meta-analysis of genome-wide association studies for personality

M.H.M. de Moor; P.T. Costa; A. Terracciano; R.F. Krueger; E.J.C. de Geus; T. Toshiko; B.W.J.H. Penninx; T. Esko; P.A.F. Madden; J. Derringer; N. Amin; G. Willemsen; J.J. Hottenga; M.A. Distel; M. Uda; S. Sanna; P. Spinhoven; C.A. Hartman; P.F. Sullivan; A. Realo; J. Allik; A.C. Heath; M.L. Pergadia; A. Agrawal; P. Lin; R.A. Grucza; T. Nutile; M. Ciullo; D. Rujescu; I. Giegling; B. Konte; E. Widen; D.L. Cousminer; J.G. Eriksson; A. Palotie; L. Peltonen; M Luciano; A. Tenesa; G. Davies; L.M. Lopez; N.K. Hansell; S.E. Medland; L. Ferrucci; D. Schlessinger; G.W. Montgomery; M.J. Wright; Y.S. Aulchenko; A.C.J.W. Janssens; B.A. Oostra; A. Metspalu; G.R. Abecasis; I.J. Deary; K. Räikkönen; L.J. Bierut; N.G. Martin; C.M. van Duijn; D.I. Boomsma

doi:10.1038/mp.2010.128

Meta-analysis of genome-wide association studies for personality

M.H.M. de Moor, P.T. Costa, A. Terracciano, R.F. Krueger, E.J.C. de Geus, T. Toshiko, B.W.J.H. Penninx, T. Esko, P.A.F. Madden, J. Derringer, N. Amin, G. Willemsen, J.J. Hottenga, M.A. Distel, M. Uda, S. Sanna, P. Spinhoven, C.A. Hartman, P.F. Sullivan, A. RealoJ. Allik, A.C. Heath, M.L. Pergadia, A. Agrawal, P. Lin, R.A. Grucza, T. Nutile, M. Ciullo, D. Rujescu, I. Giegling, B. Konte, E. Widen, D.L. Cousminer, J.G. Eriksson, A. Palotie, L. Peltonen, M Luciano, A. Tenesa, G. Davies, L.M. Lopez, N.K. Hansell, S.E. Medland, L. Ferrucci, D. Schlessinger, G.W. Montgomery, M.J. Wright, Y.S. Aulchenko, A.C.J.W. Janssens, B.A. Oostra, A. Metspalu, G.R. Abecasis, I.J. Deary, K. Räikkönen, L.J. Bierut, N.G. Martin, C.M. van Duijn, D.I. Boomsma

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17 375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness were based on the NEO Five-Factor Inventory. Genotype data of ∼2.4M single-nucleotide polymorphisms (SNPs; directly typed and imputed using HapMap data) were available. In the discovery samples, classical association analyses were performed under an additive model followed by meta-analysis using the weighted inverse variance method. Results showed genome-wide significance for Openness to Experience near the RASA1 gene on 5q14.3 (rs1477268 and rs2032794, P2.8 × 10

Original language	English
Pages (from-to)	337-349
Journal	Molecular Psychiatry
Volume	17
Issue number	3
DOIs	https://doi.org/10.1038/mp.2010.128
Publication status	Published - 2012

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de Moor, M. H. M., Costa, P. T., Terracciano, A., Krueger, R. F., de Geus, E. J. C., Toshiko, T., Penninx, B. W. J. H., Esko, T., Madden, P. A. F., Derringer, J., Amin, N., Willemsen, G., Hottenga, J. J., Distel, M. A., Uda, M., Sanna, S., Spinhoven, P., Hartman, C. A., Sullivan, P. F., ... Boomsma, D. I. (2012). Meta-analysis of genome-wide association studies for personality. Molecular Psychiatry, 17(3), 337-349. https://doi.org/10.1038/mp.2010.128

@article{d167c671cefe4f98a15684353c9a1a24,

title = "Meta-analysis of genome-wide association studies for personality",

abstract = "Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17 375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness were based on the NEO Five-Factor Inventory. Genotype data of ∼2.4M single-nucleotide polymorphisms (SNPs; directly typed and imputed using HapMap data) were available. In the discovery samples, classical association analyses were performed under an additive model followed by meta-analysis using the weighted inverse variance method. Results showed genome-wide significance for Openness to Experience near the RASA1 gene on 5q14.3 (rs1477268 and rs2032794, P2.8 × 10",

author = "{de Moor}, M.H.M. and P.T. Costa and A. Terracciano and R.F. Krueger and {de Geus}, E.J.C. and T. Toshiko and B.W.J.H. Penninx and T. Esko and P.A.F. Madden and J. Derringer and N. Amin and G. Willemsen and J.J. Hottenga and M.A. Distel and M. Uda and S. Sanna and P. Spinhoven and C.A. Hartman and P.F. Sullivan and A. Realo and J. Allik and A.C. Heath and M.L. Pergadia and A. Agrawal and P. Lin and R.A. Grucza and T. Nutile and M. Ciullo and D. Rujescu and I. Giegling and B. Konte and E. Widen and D.L. Cousminer and J.G. Eriksson and A. Palotie and L. Peltonen and M Luciano and A. Tenesa and G. Davies and L.M. Lopez and N.K. Hansell and S.E. Medland and L. Ferrucci and D. Schlessinger and G.W. Montgomery and M.J. Wright and Y.S. Aulchenko and A.C.J.W. Janssens and B.A. Oostra and A. Metspalu and G.R. Abecasis and I.J. Deary and K. R{\"a}ikk{\"o}nen and L.J. Bierut and N.G. Martin and {van Duijn}, C.M. and D.I. Boomsma",

year = "2012",

doi = "10.1038/mp.2010.128",

language = "English",

volume = "17",

pages = "337--349",

journal = "Molecular Psychiatry",

issn = "1359-4184",

publisher = "Nature Publishing Group",

number = "3",

}

de Moor, MHM, Costa, PT, Terracciano, A, Krueger, RF, de Geus, EJC, Toshiko, T, Penninx, BWJH, Esko, T, Madden, PAF, Derringer, J, Amin, N, Willemsen, G , Hottenga, JJ, Distel, MA, Uda, M, Sanna, S, Spinhoven, P, Hartman, CA, Sullivan, PF, Realo, A, Allik, J, Heath, AC, Pergadia, ML, Agrawal, A, Lin, P, Grucza, RA, Nutile, T, Ciullo, M, Rujescu, D, Giegling, I, Konte, B, Widen, E, Cousminer, DL, Eriksson, JG, Palotie, A, Peltonen, L, Luciano, M, Tenesa, A, Davies, G, Lopez, LM, Hansell, NK, Medland, SE, Ferrucci, L, Schlessinger, D, Montgomery, GW, Wright, MJ, Aulchenko, YS, Janssens, ACJW, Oostra, BA, Metspalu, A, Abecasis, GR, Deary, IJ, Räikkönen, K, Bierut, LJ, Martin, NG, van Duijn, CM & Boomsma, DI 2012, 'Meta-analysis of genome-wide association studies for personality', Molecular Psychiatry, vol. 17, no. 3, pp. 337-349. https://doi.org/10.1038/mp.2010.128

TY - JOUR

T1 - Meta-analysis of genome-wide association studies for personality

AU - de Moor, M.H.M.

AU - Costa, P.T.

AU - Terracciano, A.

AU - Krueger, R.F.

AU - de Geus, E.J.C.

AU - Toshiko, T.

AU - Penninx, B.W.J.H.

AU - Esko, T.

AU - Madden, P.A.F.

AU - Derringer, J.

AU - Amin, N.

AU - Willemsen, G.

AU - Hottenga, J.J.

AU - Distel, M.A.

AU - Uda, M.

AU - Sanna, S.

AU - Spinhoven, P.

AU - Hartman, C.A.

AU - Sullivan, P.F.

AU - Realo, A.

AU - Allik, J.

AU - Heath, A.C.

AU - Pergadia, M.L.

AU - Agrawal, A.

AU - Lin, P.

AU - Grucza, R.A.

AU - Nutile, T.

AU - Ciullo, M.

AU - Rujescu, D.

AU - Giegling, I.

AU - Konte, B.

AU - Widen, E.

AU - Cousminer, D.L.

AU - Eriksson, J.G.

AU - Palotie, A.

AU - Peltonen, L.

AU - Luciano, M

AU - Tenesa, A.

AU - Davies, G.

AU - Lopez, L.M.

AU - Hansell, N.K.

AU - Medland, S.E.

AU - Ferrucci, L.

AU - Schlessinger, D.

AU - Montgomery, G.W.

AU - Wright, M.J.

AU - Aulchenko, Y.S.

AU - Janssens, A.C.J.W.

AU - Oostra, B.A.

AU - Metspalu, A.

AU - Abecasis, G.R.

AU - Deary, I.J.

AU - Räikkönen, K.

AU - Bierut, L.J.

AU - Martin, N.G.

AU - van Duijn, C.M.

AU - Boomsma, D.I.

PY - 2012

Y1 - 2012

N2 - Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17 375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness were based on the NEO Five-Factor Inventory. Genotype data of ∼2.4M single-nucleotide polymorphisms (SNPs; directly typed and imputed using HapMap data) were available. In the discovery samples, classical association analyses were performed under an additive model followed by meta-analysis using the weighted inverse variance method. Results showed genome-wide significance for Openness to Experience near the RASA1 gene on 5q14.3 (rs1477268 and rs2032794, P2.8 × 10

AB - Personality can be thought of as a set of characteristics that influence people's thoughts, feelings and behavior across a variety of settings. Variation in personality is predictive of many outcomes in life, including mental health. Here we report on a meta-analysis of genome-wide association (GWA) data for personality in 10 discovery samples (17 375 adults) and five in silico replication samples (3294 adults). All participants were of European ancestry. Personality scores for Neuroticism, Extraversion, Openness to Experience, Agreeableness and Conscientiousness were based on the NEO Five-Factor Inventory. Genotype data of ∼2.4M single-nucleotide polymorphisms (SNPs; directly typed and imputed using HapMap data) were available. In the discovery samples, classical association analyses were performed under an additive model followed by meta-analysis using the weighted inverse variance method. Results showed genome-wide significance for Openness to Experience near the RASA1 gene on 5q14.3 (rs1477268 and rs2032794, P2.8 × 10

U2 - 10.1038/mp.2010.128

DO - 10.1038/mp.2010.128

M3 - Article

SN - 1359-4184

VL - 17

SP - 337

EP - 349

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 3

ER -

Meta-analysis of genome-wide association studies for personality

Abstract

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