Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with Excitement-Seeking

A. Terracciano, T. Esko, A.R. Sutin, M.H.M. de Moor, O. Meirelles, G. Zhu, T. Tanaka, I. Giegling, T. Nutile, A. Realo, J. Allik, N.K. Hansell, M.J. Wright, G.W. Montgomery, G. Willemsen, J.J. Hottenga, M. Friedl, D. Ruggiero, R. Sorice, S. SannaB. Deiana, F. Cucca, R.F. Krueger, A. Lahti, M. Luciano, J.W. Smoller, C.M. van Duijn, G.R. Abecasis, D.I. Boomsma, M. Ciullo, P.T. Costa, L. Ferrucci, N.G. Martin, A. Metspalu, D. Rujescu, D. Schlessinger, M. Uda

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Abstract

The tendency to seek stimulating activities and intense sensations define excitement-seeking, a personality trait akin to some aspects of sensation-seeking. This trait is a central feature of extraversion and is a component of the multifaceted impulsivity construct. Those who score high on measures of excitement-seeking are more likely to smoke, use other drugs, gamble, drive recklessly, have unsafe/unprotected sex and engage in other risky behaviors of clinical and social relevance. To identify common genetic variants associated with the Excitement-Seeking scale of the Revised NEO Personality Inventory, we performed genome-wide association studies in six samples of European ancestry (N=7860), and combined the results in a meta-analysis. We identified a genome-wide significant association between the Excitement-Seeking scale and rs7600563 (P=2 × 10
Original languageEnglish
JournalTranslational Psychiatry
Volume1
Issue numbere49
DOIs
Publication statusPublished - 2011

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