Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

L. Paternoster, M. Standl, C.M. Chen, A. Ramasamy, K. Bønnelykke, L. Duijts, M.A. Ferreira, A. Couto Alves, J.P. Thyssen, E. Albrecht, H. Baurecht, B. Feenstra, P.M.A. Sleiman, P. Hysi, N.M. Warrington, I. Curjuric, R. Myhre, J.A. Curtin, M.M. Groen-Blokhuis, M. KerkhofA. Sääf, A. Franke, D. Ellinghaus, R. Fölster-Holst, E. Dermitzakis, S.B. Montgomery, H. Prokisch, K. Heim, A.-L. Hartikainen, A. Pouta, J. Pekkanen, A.I.F. Blakemore, J.L. Buxton, M. Kaakinen, DL Duffy, P.A.F. Madden, A.C. Heath, G.W. Montgomery, P.J. Thompson, M.C. Matheson, P. Le Souëf, B. St Pourcain, G. Davey Smith, J. Henderson, J.P. Kemp, N.J. Timpson, P. Deloukas, S.M. Ring, H.-E. Wichmann, M. Müller-Nurasyid, N. Novak, N. Klopp, E. Rodríguez, W. McArdle, A. Linneberg, T. Menné, E.A. Nohr, A. Hofman, A.G. Uitterlinden, C.M. van Duijn, F. Rivadeneira, J.C. de Jongste, R.J.P. van der Valk, M. Wjst, R. Jogi, F. Geller, H.A. Boyd, J.C. Murray, C. Kim, F. Mentch, M. March, M. Mangino, T.D. Spector, V. Bataille, C.E. Pennell, P.G. Holt, P. Sly, C.M.T. Tiesler, J.J. Hottenga, D.I. Boomsma, H. Hakonarson, M. Melbye, D. Ljarvis, V.W.V. Jaddoe, C. Gieger, D.P. Strachan, N.G. Martin, M.-R. Jarvelin, J. Heinrich, D.M. Evans, S. Weidinger

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Abstract

Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 × 10
Original languageEnglish
Pages (from-to)187-192
JournalNature Genetics
Volume44
Issue number2
DOIs
Publication statusPublished - 2012

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Paternoster, L., Standl, M., Chen, C. M., Ramasamy, A., Bønnelykke, K., Duijts, L., ... Weidinger, S. (2012). Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nature Genetics, 44(2), 187-192. https://doi.org/10.1038/ng.1017