Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

L. Paternoster; M. Standl; C.M. Chen; A. Ramasamy; K. Bønnelykke; L. Duijts; M.A. Ferreira; A. Couto Alves; J.P. Thyssen; E. Albrecht; H. Baurecht; B. Feenstra; P.M.A. Sleiman; P. Hysi; N.M. Warrington; I. Curjuric; R. Myhre; J.A. Curtin; M.M. Groen-Blokhuis; M. Kerkhof; A. Sääf; A. Franke; D. Ellinghaus; R. Fölster-Holst; E. Dermitzakis; S.B. Montgomery; H. Prokisch; K. Heim; A.-L. Hartikainen; A. Pouta; J. Pekkanen; A.I.F. Blakemore; J.L. Buxton; M. Kaakinen; DL Duffy; P.A.F. Madden; A.C. Heath; G.W. Montgomery; P.J. Thompson; M.C. Matheson; P. Le Souëf; B. St Pourcain; G. Davey Smith; J. Henderson; J.P. Kemp; N.J. Timpson; P. Deloukas; S.M. Ring; H.-E. Wichmann; M. Müller-Nurasyid; N. Novak; N. Klopp; E. Rodríguez; W. McArdle; A. Linneberg; T. Menné; E.A. Nohr; A. Hofman; A.G. Uitterlinden; C.M. van Duijn; F. Rivadeneira; J.C. de Jongste; R.J.P. van der Valk; M. Wjst; R. Jogi; F. Geller; H.A. Boyd; J.C. Murray; C. Kim; F. Mentch; M. March; M. Mangino; T.D. Spector; V. Bataille; C.E. Pennell; P.G. Holt; P. Sly; C.M.T. Tiesler; J.J. Hottenga; D.I. Boomsma; H. Hakonarson; M. Melbye; D. Ljarvis; V.W.V. Jaddoe; C. Gieger; D.P. Strachan; N.G. Martin; M.-R. Jarvelin; J. Heinrich; D.M. Evans; S. Weidinger

doi:10.1038/ng.1017

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

L. Paternoster, M. Standl, C.M. Chen, A. Ramasamy, K. Bønnelykke, L. Duijts, M.A. Ferreira, A. Couto Alves, J.P. Thyssen, E. Albrecht, H. Baurecht, B. Feenstra, P.M.A. Sleiman, P. Hysi, N.M. Warrington, I. Curjuric, R. Myhre, J.A. Curtin, M.M. Groen-Blokhuis, M. KerkhofA. Sääf, A. Franke, D. Ellinghaus, R. Fölster-Holst, E. Dermitzakis, S.B. Montgomery, H. Prokisch, K. Heim, A.-L. Hartikainen, A. Pouta, J. Pekkanen, A.I.F. Blakemore, J.L. Buxton, M. Kaakinen, DL Duffy, P.A.F. Madden, A.C. Heath, G.W. Montgomery, P.J. Thompson, M.C. Matheson, P. Le Souëf, B. St Pourcain, G. Davey Smith, J. Henderson, J.P. Kemp, N.J. Timpson, P. Deloukas, S.M. Ring, H.-E. Wichmann, M. Müller-Nurasyid, N. Novak, N. Klopp, E. Rodríguez, W. McArdle, A. Linneberg, T. Menné, E.A. Nohr, A. Hofman, A.G. Uitterlinden, C.M. van Duijn, F. Rivadeneira, J.C. de Jongste, R.J.P. van der Valk, M. Wjst, R. Jogi, F. Geller, H.A. Boyd, J.C. Murray, C. Kim, F. Mentch, M. March, M. Mangino, T.D. Spector, V. Bataille, C.E. Pennell, P.G. Holt, P. Sly, C.M.T. Tiesler, J.J. Hottenga, D.I. Boomsma, H. Hakonarson, M. Melbye, D. Ljarvis, V.W.V. Jaddoe, C. Gieger, D.P. Strachan, N.G. Martin, M.-R. Jarvelin, J. Heinrich, D.M. Evans, S. Weidinger

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 × 10

Original language	English
Pages (from-to)	187-192
Journal	Nature Genetics
Volume	44
Issue number	2
DOIs	https://doi.org/10.1038/ng.1017
Publication status	Published - 2012

Cohort Studies

Netherlands Twin Register (NTR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng.1017

Persistent URL (handle)

Persistent link

Cite this

Paternoster, L., Standl, M., Chen, C. M., Ramasamy, A., Bønnelykke, K., Duijts, L., Ferreira, M. A., Couto Alves, A., Thyssen, J. P., Albrecht, E., Baurecht, H., Feenstra, B., Sleiman, P. M. A., Hysi, P., Warrington, N. M., Curjuric, I., Myhre, R., Curtin, J. A., Groen-Blokhuis, M. M., ... Weidinger, S. (2012). Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nature Genetics, 44(2), 187-192. https://doi.org/10.1038/ng.1017

@article{4bb4f182394a4c3082c0ad8977ff9dea,

title = "Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis",

abstract = "Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 × 10",

author = "L. Paternoster and M. Standl and C.M. Chen and A. Ramasamy and K. B{\o}nnelykke and L. Duijts and M.A. Ferreira and \{Couto Alves\}, A. and J.P. Thyssen and E. Albrecht and H. Baurecht and B. Feenstra and P.M.A. Sleiman and P. Hysi and N.M. Warrington and I. Curjuric and R. Myhre and J.A. Curtin and M.M. Groen-Blokhuis and M. Kerkhof and A. S{\"a}{\"a}f and A. Franke and D. Ellinghaus and R. F{\"o}lster-Holst and E. Dermitzakis and S.B. Montgomery and H. Prokisch and K. Heim and A.-L. Hartikainen and A. Pouta and J. Pekkanen and A.I.F. Blakemore and J.L. Buxton and M. Kaakinen and DL Duffy and P.A.F. Madden and A.C. Heath and G.W. Montgomery and P.J. Thompson and M.C. Matheson and \{Le Sou{\"e}f\}, P. and \{St Pourcain\}, B. and \{Davey Smith\}, G. and J. Henderson and J.P. Kemp and N.J. Timpson and P. Deloukas and S.M. Ring and H.-E. Wichmann and M. M{\"u}ller-Nurasyid and N. Novak and N. Klopp and E. Rodr{\'i}guez and W. McArdle and A. Linneberg and T. Menn{\'e} and E.A. Nohr and A. Hofman and A.G. Uitterlinden and \{van Duijn\}, C.M. and F. Rivadeneira and \{de Jongste\}, J.C. and \{van der Valk\}, R.J.P. and M. Wjst and R. Jogi and F. Geller and H.A. Boyd and J.C. Murray and C. Kim and F. Mentch and M. March and M. Mangino and T.D. Spector and V. Bataille and C.E. Pennell and P.G. Holt and P. Sly and C.M.T. Tiesler and J.J. Hottenga and D.I. Boomsma and H. Hakonarson and M. Melbye and D. Ljarvis and V.W.V. Jaddoe and C. Gieger and D.P. Strachan and N.G. Martin and M.-R. Jarvelin and J. Heinrich and D.M. Evans and S. Weidinger",

year = "2012",

doi = "10.1038/ng.1017",

language = "English",

volume = "44",

pages = "187--192",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "2",

}

Paternoster, L, Standl, M, Chen, CM, Ramasamy, A, Bønnelykke, K, Duijts, L, Ferreira, MA, Couto Alves, A, Thyssen, JP, Albrecht, E, Baurecht, H, Feenstra, B, Sleiman, PMA, Hysi, P, Warrington, NM, Curjuric, I, Myhre, R, Curtin, JA, Groen-Blokhuis, MM, Kerkhof, M, Sääf, A, Franke, A, Ellinghaus, D, Fölster-Holst, R, Dermitzakis, E, Montgomery, SB, Prokisch, H, Heim, K, Hartikainen, A-L, Pouta, A, Pekkanen, J, Blakemore, AIF, Buxton, JL, Kaakinen, M, Duffy, DL, Madden, PAF, Heath, AC, Montgomery, GW, Thompson, PJ, Matheson, MC, Le Souëf, P, St Pourcain, B, Davey Smith, G, Henderson, J, Kemp, JP, Timpson, NJ, Deloukas, P, Ring, SM, Wichmann, H-E, Müller-Nurasyid, M, Novak, N, Klopp, N, Rodríguez, E, McArdle, W, Linneberg, A, Menné, T, Nohr, EA, Hofman, A, Uitterlinden, AG, van Duijn, CM, Rivadeneira, F, de Jongste, JC, van der Valk, RJP, Wjst, M, Jogi, R, Geller, F, Boyd, HA, Murray, JC, Kim, C, Mentch, F, March, M, Mangino, M, Spector, TD, Bataille, V, Pennell, CE, Holt, PG, Sly, P, Tiesler, CMT, Hottenga, JJ, Boomsma, DI, Hakonarson, H, Melbye, M, Ljarvis, D, Jaddoe, VWV, Gieger, C, Strachan, DP, Martin, NG, Jarvelin, M-R, Heinrich, J, Evans, DM & Weidinger, S 2012, 'Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis', Nature Genetics, vol. 44, no. 2, pp. 187-192. https://doi.org/10.1038/ng.1017

TY - JOUR

T1 - Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

AU - Paternoster, L.

AU - Standl, M.

AU - Chen, C.M.

AU - Ramasamy, A.

AU - Bønnelykke, K.

AU - Duijts, L.

AU - Ferreira, M.A.

AU - Couto Alves, A.

AU - Thyssen, J.P.

AU - Albrecht, E.

AU - Baurecht, H.

AU - Feenstra, B.

AU - Sleiman, P.M.A.

AU - Hysi, P.

AU - Warrington, N.M.

AU - Curjuric, I.

AU - Myhre, R.

AU - Curtin, J.A.

AU - Groen-Blokhuis, M.M.

AU - Kerkhof, M.

AU - Sääf, A.

AU - Franke, A.

AU - Ellinghaus, D.

AU - Fölster-Holst, R.

AU - Dermitzakis, E.

AU - Montgomery, S.B.

AU - Prokisch, H.

AU - Heim, K.

AU - Hartikainen, A.-L.

AU - Pouta, A.

AU - Pekkanen, J.

AU - Blakemore, A.I.F.

AU - Buxton, J.L.

AU - Kaakinen, M.

AU - Duffy, DL

AU - Madden, P.A.F.

AU - Heath, A.C.

AU - Montgomery, G.W.

AU - Thompson, P.J.

AU - Matheson, M.C.

AU - Le Souëf, P.

AU - St Pourcain, B.

AU - Davey Smith, G.

AU - Henderson, J.

AU - Kemp, J.P.

AU - Timpson, N.J.

AU - Deloukas, P.

AU - Ring, S.M.

AU - Wichmann, H.-E.

AU - Müller-Nurasyid, M.

AU - Novak, N.

AU - Klopp, N.

AU - Rodríguez, E.

AU - McArdle, W.

AU - Linneberg, A.

AU - Menné, T.

AU - Nohr, E.A.

AU - Hofman, A.

AU - Uitterlinden, A.G.

AU - van Duijn, C.M.

AU - Rivadeneira, F.

AU - de Jongste, J.C.

AU - van der Valk, R.J.P.

AU - Wjst, M.

AU - Jogi, R.

AU - Geller, F.

AU - Boyd, H.A.

AU - Murray, J.C.

AU - Kim, C.

AU - Mentch, F.

AU - March, M.

AU - Mangino, M.

AU - Spector, T.D.

AU - Bataille, V.

AU - Pennell, C.E.

AU - Holt, P.G.

AU - Sly, P.

AU - Tiesler, C.M.T.

AU - Hottenga, J.J.

AU - Boomsma, D.I.

AU - Hakonarson, H.

AU - Melbye, M.

AU - Ljarvis, D.

AU - Jaddoe, V.W.V.

AU - Gieger, C.

AU - Strachan, D.P.

AU - Martin, N.G.

AU - Jarvelin, M.-R.

AU - Heinrich, J.

AU - Evans, D.M.

AU - Weidinger, S.

PY - 2012

Y1 - 2012

N2 - Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 × 10

AB - Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 × 10

UR - https://www.scopus.com/pages/publications/84856283235

UR - https://www.scopus.com/inward/citedby.url?scp=84856283235&partnerID=8YFLogxK

U2 - 10.1038/ng.1017

DO - 10.1038/ng.1017

M3 - Article

SN - 1061-4036

VL - 44

SP - 187

EP - 192

JO - Nature Genetics

JF - Nature Genetics

IS - 2

ER -

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

Abstract

Cohort Studies

UN SDGs

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this