Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects.

J. Ciapaite, S.J. Bakker, M. Diamant, G. van Eikenhorst, R.J. Heine, H.V. Westerhoff, K. Krab

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Inhibition of the mitochondrial adenine nucleotide translocator (ANT) by long-chain acyl-CoA esters has been proposed to contribute to cellular dysfunction in obesity and type 2 diabetes by increasing formation of reactive oxygen species and adenosine via effects on the coenzyme Q redox state, mitochondrial membrane potential (Δψ) and cytosolic ATP concentrations. We here show that 5 μm palmitoyl-CoA increases the ratio of reduced to oxidized coenzyme Q (QH
Original languageEnglish
Pages (from-to)5288-5302
Number of pages15
JournalThe FEBS Journal
Volume273
DOIs
Publication statusPublished - 2006

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