Metabolic modeling of fungi

Sebastián N. Mendoza*, Sara Calhoun, Bas Teusink, María Victoria Aguilar-Pontes

*Corresponding author for this work

Research output: Chapter in Book / Report / Conference proceedingEntry for encyclopedia/dictionaryAcademicpeer-review


Fungi have received special interest from the biotechnological sector focused on the production of active biomolecules and strain engineering. Genome-scale metabolic models (GEMs) are used to understand and improve their metabolism. GEMs can be obtained using computational methods, but they are susceptible to errors. Here, we describe the process to reconstruct a GEM and discuss several methodologies for analysis and validation of the model. We review different applications and explore the latest advances in GEM reconstruction to ease the process. With the new developments, we will be able to reconstruct and analyze high-quality GEMs for non-model species.
Original languageEnglish
Title of host publicationEncyclopedia of Mycology
EditorsÓscar Zaragoza, Arturo Casadevall
Number of pages12
ISBN (Electronic)9780323851800
ISBN (Print)9780128199909
Publication statusPublished - 2021


Dive into the research topics of 'Metabolic modeling of fungi'. Together they form a unique fingerprint.

Cite this