Metabolism of 1-fluoropyrene and pyrene in marine flatfish and terrestrial isopods

G. luthe, G. Stroomberg, F. Ariese, U.A.T. Brinkman, N.M Straalen

Research output: Contribution to JournalArticleAcademicpeer-review


Monofluorinated polycyclic aromatic hydrocarbons (F-PAHs) are useful reference compounds for a broad spectrum of PAH studies. The pyrene metabolite 1-hydroxypyrene is often used as a biomarker of PAH exposure. Two species, isopod (Porcellio scaber) and flatfish (Platichthys flesus), that produce 1-hydroxypyrene as the major intermediary metabolite and have distinct phase-II conjugates, were selected to investigate the cytochrome P450 catalyzed metabolism of 1-fluoropyrene. The fluorine atom blocks one of the four most favored carbon atoms, yielding different metabolite patterns and the results obtained in the selected species were compared with metabolite profiles obtained for unsubstituted pyrene. Charge densities in 1-fluoropyrene measured with
Original languageEnglish
Pages (from-to)221-229
JournalEnvironmental Toxicology and Pharmacology
Issue number4
Publication statusPublished - 2002


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