Metabolite Depletion Affects Flux Profiling of Cell Lines

A. Nilsson; J. R. Haanstra; B. Teusink; J. Nielsen

doi:10.1016/j.tibs.2018.03.009

Metabolite Depletion Affects Flux Profiling of Cell Lines

A. Nilsson, J. R. Haanstra, B. Teusink, J. Nielsen^*

^*Corresponding author for this work

Research output: Contribution to Journal › Short survey › Academic › peer-review

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Abstract

Quantifying the rate of consumption and release of metabolites (i.e., flux profiling) has become integral to the study of cancer. The fluxes as well as the growth of the cells may be affected by metabolite depletion during cultivation.

Original language	English
Pages (from-to)	395-397
Number of pages	3
Journal	Trends in Biochemical Sciences
Volume	43
Issue number	6
Early online date	12 Apr 2018
DOIs	https://doi.org/10.1016/j.tibs.2018.03.009
Publication status	Published - Jun 2018

Keywords

cancer
glutamine
metabolic modeling
serine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tibs.2018.03.009

Metabolite Depletion Affects Flux Profiling of Cell LinesFinal published version, 609 KBLicence: Article 25fa Dutch Copyright Act

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title = "Metabolite Depletion Affects Flux Profiling of Cell Lines",

abstract = "Quantifying the rate of consumption and release of metabolites (i.e., flux profiling) has become integral to the study of cancer. The fluxes as well as the growth of the cells may be affected by metabolite depletion during cultivation.",

keywords = "cancer, glutamine, metabolic modeling, serine",

author = "A. Nilsson and Haanstra, {J. R.} and B. Teusink and J. Nielsen",

year = "2018",

month = jun,

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language = "English",

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journal = "Trends in Biochemical Sciences",

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AU - Nilsson, A.

AU - Haanstra, J. R.

AU - Teusink, B.

AU - Nielsen, J.

PY - 2018/6

Y1 - 2018/6

N2 - Quantifying the rate of consumption and release of metabolites (i.e., flux profiling) has become integral to the study of cancer. The fluxes as well as the growth of the cells may be affected by metabolite depletion during cultivation.

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KW - cancer

KW - glutamine

KW - metabolic modeling

KW - serine

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U2 - 10.1016/j.tibs.2018.03.009

DO - 10.1016/j.tibs.2018.03.009

M3 - Short survey

C2 - 29656822

SN - 0968-0004

VL - 43

SP - 395

EP - 397

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 6

ER -

Metabolite Depletion Affects Flux Profiling of Cell Lines

Abstract

Keywords

UN SDGs

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