Abstract
Parkinson’s disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum, a non-invasively available biofluid. We used liquid chromatography-mass spectrometry (LC-MS) to analyse 274 samples from participants (80 drug naïve PD, 138 medicated PD and 56 well matched control subjects) and detected metabolites that could predict PD phenotype. Pathway enrichment analysis shows alterations in lipid metabolism related to the carnitine shuttle, sphingolipid metabolism, arachidonic acid metabolism and fatty acid biosynthesis. This study shows sebum can be used to identify potential biomarkers for PD.
| Original language | English |
|---|---|
| Article number | 1592 |
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Nature Communications |
| Volume | 12 |
| Early online date | 11 Mar 2021 |
| DOIs | |
| Publication status | Published - 2021 |
Bibliographical note
Funding Information:We thank Michael J Fox Foundation (grant ref:12921) and Parkinson’s UK (grant ref: K-1504) for funding this study. This work was supported by an EPSRC DTA grant to the School of Chemistry, which has funded the PhD project of E.S., a BBSRC DTP grant which has funded the PhD project of C.W.D. (BB/R505869/1) and the BBSRC (award BB/L015048/1) for instrumentation used in this work. We also thank our recruitment centres (See supporting information for lead personnel) for their enthusiasm and rigor during the recruitment process. We are very grateful to all the participants who took part in this study as well as PIs and nurses across all the recruiting centres. We also thank Richard Weller for feedback and discussions on sebum and dermatology.
Publisher Copyright:
© 2021, The Author(s).
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
Funding
We thank Michael J Fox Foundation (grant ref:12921) and Parkinson’s UK (grant ref: K-1504) for funding this study. This work was supported by an EPSRC DTA grant to the School of Chemistry, which has funded the PhD project of E.S., a BBSRC DTP grant which has funded the PhD project of C.W.D. (BB/R505869/1) and the BBSRC (award BB/L015048/1) for instrumentation used in this work. We also thank our recruitment centres (See supporting information for lead personnel) for their enthusiasm and rigor during the recruitment process. We are very grateful to all the participants who took part in this study as well as PIs and nurses across all the recruiting centres. We also thank Richard Weller for feedback and discussions on sebum and dermatology.
| Funders | Funder number |
|---|---|
| Engineering and Physical Sciences Research Council | |
| UK Research and Innovation | |
| Biotechnology and Biological Sciences Research Council | BB/R505869/1, BB/L015048/1 |
| Parkinson's UK | K-1504 |
| Michael J. Fox Foundation for Parkinson's Research | 12921 |
