Microbial-catalysed resolution of sterically demanding cyanohydrins

M. Paravidino; J. Holt; D. Romano; N. Singh; I.W.C.E. Arends; A.J. Minnaard; R.V.A. Orru; F. Molinari; U. Hanefeld

doi:10.1016/j.molcatb.2009.12.014

Microbial-catalysed resolution of sterically demanding cyanohydrins

M. Paravidino
, J. Holt
, D. Romano
, N. Singh
, I.W.C.E. Arends
, A.J. Minnaard
, R.V.A. Orru
, F. Molinari
, U. Hanefeld

AIMMS

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Mycelia containing carboxyl-esterases, a novel source of enzymes, have been investigated in the hydrolytic kinetic resolution of one type of tert-alcohols, α,α-disubstituted cyanohydrins. This class of enzymes was found to be both active and selective towards these tert-alcohols, giving E-values as high as 42. © 2009 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	87-92
Number of pages	6
Journal	Journal of Molecular Catalysis B. Enzymatic
Volume	63
Issue number	1-2
DOIs	https://doi.org/10.1016/j.molcatb.2009.12.014
Publication status	Published - 2011

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10.1016/j.molcatb.2009.12.014

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title = "Microbial-catalysed resolution of sterically demanding cyanohydrins",

abstract = "Mycelia containing carboxyl-esterases, a novel source of enzymes, have been investigated in the hydrolytic kinetic resolution of one type of tert-alcohols, α,α-disubstituted cyanohydrins. This class of enzymes was found to be both active and selective towards these tert-alcohols, giving E-values as high as 42. {\textcopyright} 2009 Elsevier B.V. All rights reserved.",

author = "M. Paravidino and J. Holt and D. Romano and N. Singh and I.W.C.E. Arends and A.J. Minnaard and R.V.A. Orru and F. Molinari and U. Hanefeld",

year = "2011",

doi = "10.1016/j.molcatb.2009.12.014",

language = "English",

volume = "63",

pages = "87--92",

journal = "Journal of Molecular Catalysis B. Enzymatic",

issn = "1381-1177",

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T1 - Microbial-catalysed resolution of sterically demanding cyanohydrins

AU - Paravidino, M.

AU - Holt, J.

AU - Romano, D.

AU - Singh, N.

AU - Arends, I.W.C.E.

AU - Minnaard, A.J.

AU - Orru, R.V.A.

AU - Molinari, F.

AU - Hanefeld, U.

PY - 2011

Y1 - 2011

N2 - Mycelia containing carboxyl-esterases, a novel source of enzymes, have been investigated in the hydrolytic kinetic resolution of one type of tert-alcohols, α,α-disubstituted cyanohydrins. This class of enzymes was found to be both active and selective towards these tert-alcohols, giving E-values as high as 42. © 2009 Elsevier B.V. All rights reserved.

AB - Mycelia containing carboxyl-esterases, a novel source of enzymes, have been investigated in the hydrolytic kinetic resolution of one type of tert-alcohols, α,α-disubstituted cyanohydrins. This class of enzymes was found to be both active and selective towards these tert-alcohols, giving E-values as high as 42. © 2009 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.molcatb.2009.12.014

DO - 10.1016/j.molcatb.2009.12.014

M3 - Article

SN - 1381-1177

VL - 63

SP - 87

EP - 92

JO - Journal of Molecular Catalysis B. Enzymatic

JF - Journal of Molecular Catalysis B. Enzymatic

IS - 1-2

ER -

Microbial-catalysed resolution of sterically demanding cyanohydrins

Abstract

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