TY - JOUR
T1 - Microplicae: specialized surface structure of epithelial cells of wet-surfaced oral mucosa
AU - Asikainen, P.
AU - Sirviö, E.
AU - Mikkonen, J.J.W.
AU - Singh, S.P.
AU - Schulten, E.A.J.M.
AU - ten Bruggenkate, C.M.
AU - Koistinen, A.P.
AU - Kullaa, A.M.
PY - 2015
Y1 - 2015
N2 - The surface structure of the superficial cells of the oral mucosa is decorated with numerous membrane ridges, termed microplicae (MPLs). The MPL structure is typical of the epithelial surfaces that are covered with protective mucus. Cell membrane MPLs are no longer seen as passive consequences of cellular activity. The interaction between MPLs and the mucins has been demonstrated, however the role of MPL structure seen on the upper surface of the oral epithelial cells is speculative. The cell surface is of potentially great significance, as it harbors many markers for refined prognosis and targets for oral mucosal diseases and cancer therapy. With these aspects in mind, we conducted the present review of the MPL structure and function in order to form the basis for further studies of MPLs of the oral epithelial cells.
AB - The surface structure of the superficial cells of the oral mucosa is decorated with numerous membrane ridges, termed microplicae (MPLs). The MPL structure is typical of the epithelial surfaces that are covered with protective mucus. Cell membrane MPLs are no longer seen as passive consequences of cellular activity. The interaction between MPLs and the mucins has been demonstrated, however the role of MPL structure seen on the upper surface of the oral epithelial cells is speculative. The cell surface is of potentially great significance, as it harbors many markers for refined prognosis and targets for oral mucosal diseases and cancer therapy. With these aspects in mind, we conducted the present review of the MPL structure and function in order to form the basis for further studies of MPLs of the oral epithelial cells.
UR - https://www.scopus.com/pages/publications/84942501428
UR - https://www.scopus.com/inward/citedby.url?scp=84942501428&partnerID=8YFLogxK
U2 - 10.3109/01913123.2015.1054015
DO - 10.3109/01913123.2015.1054015
M3 - Article
SN - 0191-3123
VL - 39
SP - 299
EP - 305
JO - Ultrastructural pathology
JF - Ultrastructural pathology
IS - 5
ER -
