Migraine mutations impair hippocampal learning despite enhanced long-term potentiation.

E. Dilekoz; T. Houben; K. Eikermann-Hearter; M. Balkaya; A.M. Lenselink; M.J. Whalen; S. Spijker; M.D. Ferrari; A.M.J.M. van den Maagdenberg; C. Ayate

doi:10.1523/JNEUROSCI.2630-14.2015

Migraine mutations impair hippocampal learning despite enhanced long-term potentiation.

E. Dilekoz
, T. Houben
, K. Eikermann-Hearter
, M. Balkaya
, A.M. Lenselink
, M.J. Whalen
, S. Spijker
, M.D. Ferrari
, A.M.J.M. van den Maagdenberg
, C. Ayate

Molecular and Cellular Neurobiology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

To explain cognitive and memory difficulties observed in some familial hemiplegic migraine (FHM) patients, we examined hippocampal neurotransmission and plasticity in knock-in mice expressing theFHMtype 1 (FHM1) R192Q gain-of function mutation in the CACNA1A gene that encodes the α

Original language	English
Pages (from-to)	3397-3402
Journal	The Journal of Neuroscience
Volume	35
Issue number	8
DOIs	https://doi.org/10.1523/JNEUROSCI.2630-14.2015
Publication status	Published - 2015

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 10 Reduced Inequalities

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10.1523/JNEUROSCI.2630-14.2015

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title = "Migraine mutations impair hippocampal learning despite enhanced long-term potentiation.",

abstract = "To explain cognitive and memory difficulties observed in some familial hemiplegic migraine (FHM) patients, we examined hippocampal neurotransmission and plasticity in knock-in mice expressing theFHMtype 1 (FHM1) R192Q gain-of function mutation in the CACNA1A gene that encodes the α",

author = "E. Dilekoz and T. Houben and K. Eikermann-Hearter and M. Balkaya and A.M. Lenselink and M.J. Whalen and S. Spijker and M.D. Ferrari and \{van den Maagdenberg\}, A.M.J.M. and C. Ayate",

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doi = "10.1523/JNEUROSCI.2630-14.2015",

language = "English",

volume = "35",

pages = "3397--3402",

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TY - JOUR

T1 - Migraine mutations impair hippocampal learning despite enhanced long-term potentiation.

AU - Dilekoz, E.

AU - Houben, T.

AU - Eikermann-Hearter, K.

AU - Balkaya, M.

AU - Lenselink, A.M.

AU - Whalen, M.J.

AU - Spijker, S.

AU - Ferrari, M.D.

AU - van den Maagdenberg, A.M.J.M.

AU - Ayate, C.

PY - 2015

Y1 - 2015

N2 - To explain cognitive and memory difficulties observed in some familial hemiplegic migraine (FHM) patients, we examined hippocampal neurotransmission and plasticity in knock-in mice expressing theFHMtype 1 (FHM1) R192Q gain-of function mutation in the CACNA1A gene that encodes the α

AB - To explain cognitive and memory difficulties observed in some familial hemiplegic migraine (FHM) patients, we examined hippocampal neurotransmission and plasticity in knock-in mice expressing theFHMtype 1 (FHM1) R192Q gain-of function mutation in the CACNA1A gene that encodes the α

U2 - 10.1523/JNEUROSCI.2630-14.2015

DO - 10.1523/JNEUROSCI.2630-14.2015

M3 - Article

SN - 0270-6474

VL - 35

SP - 3397

EP - 3402

JO - The Journal of Neuroscience

JF - The Journal of Neuroscience

IS - 8

ER -

Migraine mutations impair hippocampal learning despite enhanced long-term potentiation.

Abstract

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