TY - JOUR
T1 - Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment
AU - Vinkers, C.H.
AU - Joels, M.
AU - Milaneschi, Y.
AU - Gerritsen, L.
AU - Kahn, R. S.
AU - Penninx, B.W.J.H.
AU - Boks, M.P.M.
PY - 2015
Y1 - 2015
N2 - The MR is an important regulator of the hypothalamic-pituitary-adrenal (HPA) axis and a prime target for corticosteroids. There is increasing evidence from both clinical and preclinical studies that the MR has different effects on behavior and mood in males and females. To investigate the hypothesis that the MR sex-dependently influences the relation between childhood maltreatment and depression, we investigated three common and functional MR haplotypes (GA, CA, and CG haplotype, based on rs5522 and rs2070951) in a population-based cohort (N=665) and an independent clinical cohort from the Netherlands Study of Depression and Anxiety (NESDA) (N=1639). The CA haplotype sex-dependently moderated the relation between childhood maltreatment and depressive symptoms both in the population-based sample (sex×maltreatment×haplotype: β=-4.07, P=0.029) and in the clinical sample (sex×maltreatment×haplotype, β=-2.40, P=0.011). Specifically, female individuals in the population-based sample were protected (β=-4.58, P=2.0e
AB - The MR is an important regulator of the hypothalamic-pituitary-adrenal (HPA) axis and a prime target for corticosteroids. There is increasing evidence from both clinical and preclinical studies that the MR has different effects on behavior and mood in males and females. To investigate the hypothesis that the MR sex-dependently influences the relation between childhood maltreatment and depression, we investigated three common and functional MR haplotypes (GA, CA, and CG haplotype, based on rs5522 and rs2070951) in a population-based cohort (N=665) and an independent clinical cohort from the Netherlands Study of Depression and Anxiety (NESDA) (N=1639). The CA haplotype sex-dependently moderated the relation between childhood maltreatment and depressive symptoms both in the population-based sample (sex×maltreatment×haplotype: β=-4.07, P=0.029) and in the clinical sample (sex×maltreatment×haplotype, β=-2.40, P=0.011). Specifically, female individuals in the population-based sample were protected (β=-4.58, P=2.0e
U2 - 10.1016/j.psyneuen.2015.01.018
DO - 10.1016/j.psyneuen.2015.01.018
M3 - Article
SN - 0306-4530
VL - 54
SP - 90
EP - 102
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
ER -
