Mistaken identity: Paracetamol induces amino acid starvation through mimicry of tyrosine and changes ubiquitin homeostasis

A. Huseinovic

Mistaken identity: Paracetamol induces amino acid starvation through mimicry of tyrosine and changes ubiquitin homeostasis

A. Huseinovic

Research output: PhD Thesis › PhD-Thesis - Research and graduation internal

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Original language	English
Qualification	PhD
Awarding Institution	Vrije Universiteit Amsterdam
Supervisors/Advisors	Vermeulen, Nico P.E., Supervisor Kooter, Jan, Co-supervisor Vos, JC, Co-supervisor
Award date	24 May 2019
Print ISBNs	9789463802901
Publication status	Published - 2019

Keywords

Paracetamol
acetaminophen
amino acid
chemogenomic screen
deubiquitinases
nutrient starvation
toxicity
tryptophan
tyrosine
ubiquitin
yeast

Access to Document

CoverFinal published version, 1.89 MB
Title pageFinal published version, 55.5 KB
Abstract dutchFinal published version, 516 KB
Abstract englishFinal published version, 846 KB
Table of contentsFinal published version, 72.8 KB
Complete dissertationFinal published version, 14.8 MB
Chapter 1 General introduction and aims of this thesisFinal published version, 3.81 MB
Chapter 2 The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiaeFinal published version, 2.98 MB
Chapter 3 Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panelFinal published version, 3.74 MB
Chapter 4 Acetaminophen causes tryptophan depletionFinal published version, 1.93 MB
Chapter 5 Summary, conclusions and future perspectivesFinal published version, 1.4 MB
Appendix AppendicesFinal published version, 403 KB

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Cite this

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title = "Mistaken identity: Paracetamol induces amino acid starvation through mimicry of tyrosine and changes ubiquitin homeostasis",

keywords = "Paracetamol, acetaminophen, amino acid, chemogenomic screen, deubiquitinases, nutrient starvation, toxicity, tryptophan, tyrosine, ubiquitin, yeast",

author = "A. Huseinovic",

year = "2019",

language = "English",

isbn = "9789463802901",

type = "PhD-Thesis - Research and graduation internal",

school = "Vrije Universiteit Amsterdam",

}

TY - THES

T1 - Mistaken identity: Paracetamol induces amino acid starvation through mimicry of tyrosine and changes ubiquitin homeostasis

AU - Huseinovic, A.

PY - 2019

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KW - Paracetamol

KW - acetaminophen

KW - amino acid

KW - chemogenomic screen

KW - deubiquitinases

KW - nutrient starvation

KW - toxicity

KW - tryptophan

KW - tyrosine

KW - ubiquitin

KW - yeast

M3 - PhD-Thesis - Research and graduation internal

SN - 9789463802901

ER -