Modelling and mutation studies on the histamine H₁-receptor agonist binding site reveal different binding modes for H₁-agonists: Asp^116 (TM3) has a constitutive role in receptor stimulation.

A.M. ter Laak, H. Timmerman, R. Leurs, P.H.J. Nederkoorn, M.J. Smit, G.M. Donnè-op den Kelder

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

A modelling study has been carried out, investigating the binding of histamine (Hist), 2-methylhistamine (2-MeHist) and 2-phenylhistamine (2-PhHist) at two postulated agonistic binding sites on transmembrane domain 5 (TM5) of the histamine H
Original languageEnglish
Pages (from-to)319-330
JournalJournal of Computer-aided Molecular Design
Volume9
DOIs
Publication statusPublished - 1995

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