Modelling and mutation studies on the histamine H₁-receptor agonist binding site reveal different binding modes for H₁-agonists: Asp^116 (TM3) has a constitutive role in receptor stimulation.

A.M. ter Laak, H. Timmerman, R. Leurs, P.H.J. Nederkoorn, M.J. Smit, G.M. Donnè-op den Kelder

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