The present paper aims at developing a new research approach based on the synergy concept as a driving force in network analysis and modelling. Starting from some introductory reflections identifying the role of network synergy in regional development and transportation science, the paper aims at giving a new interpretation of synergy effects in a network by focussing the attention on three dimensions of economic network analysis, based on the related(network) production functions. These dimensions or levels are: network links, uni-modal networks and multi-modal networks. In the paper, first a static economic analysis is carried out with particular attention to the role played by connectivity and diversity among actors/segments/layers in a network. Next, the restructuring effects of either complementarity or competition between different links and modalities will be investigated by looking at the dynamic aspects of network performance by revisiting and investigating concepts from evolutionary ecology in connection with resilience and sustainability issues.