TY - JOUR
T1 - Modifiable risk factors for prevention of dementia in midlife, late life and the oldest-old: Validation of the LIBRA index
AU - Vos, Stephanie J. B.
AU - Van Boxtel, Martin P J
AU - Schiepers, Olga J. G.
AU - Deckers, Kay
AU - de Vugt, Marjolein
AU - Carriere, Isabelle
AU - Dartigues, Jean-Francois
AU - Peres, Karine
AU - Artero, Sylvaine
AU - Ritchie, Karen
AU - Galluzzo, Lucia
AU - Scafato, Emanuele
AU - Frison, Giovanni B.
AU - Huisman, Martijn
AU - Comijs, Hannie C.
AU - Sacuiu, Simona F.
AU - Skoog, Ingmar
AU - Irving, Kate
AU - O'Donnell, Catherine A.
AU - Verhey, Frans R. J.
AU - Visser, Pieter Jelle
AU - Kohler, Sebastian
PY - 2017
Y1 - 2017
N2 - Background: Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual's prevention potential for dementia. Objective: We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old. Methods: 9,387 non-demented individuals were recruited from the European population-based DESCRIPAstudy.An individual'sLIBRAindexwas calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild/moderate alcohol use. Cox regression was used to test the predictive validity of LIBRA for dementia at follow-up (mean 7.2 y, range 1 16). Results: In midlife (55 69 y, n = 3,256) and late life (70 79 y, n = 4,320), the risk for dementia increased with higher LIBRA scores. Individuals in the intermediate- and high-risk groups had a higher risk of dementia than those in the low-risk group. In the oldest-old (80 97 y, n = 1,811), higher LIBRA scores did not increase the risk for dementia. Conclusion: LIBRA might be a useful tool to identify individuals for primary prevention interventions of dementia in midlife, and maybe in late life, but not in the oldest-old.
AB - Background: Recently, the LIfestyle for BRAin health (LIBRA) index was developed to assess an individual's prevention potential for dementia. Objective: We investigated the predictive validity of the LIBRA index for incident dementia in midlife, late life, and the oldest-old. Methods: 9,387 non-demented individuals were recruited from the European population-based DESCRIPAstudy.An individual'sLIBRAindexwas calculated solely based on modifiable risk factors: depression, diabetes, physical activity, hypertension, obesity, smoking, hypercholesterolemia, coronary heart disease, and mild/moderate alcohol use. Cox regression was used to test the predictive validity of LIBRA for dementia at follow-up (mean 7.2 y, range 1 16). Results: In midlife (55 69 y, n = 3,256) and late life (70 79 y, n = 4,320), the risk for dementia increased with higher LIBRA scores. Individuals in the intermediate- and high-risk groups had a higher risk of dementia than those in the low-risk group. In the oldest-old (80 97 y, n = 1,811), higher LIBRA scores did not increase the risk for dementia. Conclusion: LIBRA might be a useful tool to identify individuals for primary prevention interventions of dementia in midlife, and maybe in late life, but not in the oldest-old.
KW - Aging
KW - dementia
KW - modifiable risk factors
KW - prevention
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UR - http://www.scopus.com/inward/citedby.url?scp=85019263466&partnerID=8YFLogxK
U2 - 10.3233/JAD-161208
DO - 10.3233/JAD-161208
M3 - Article
SN - 1387-2877
VL - 58
SP - 537
EP - 547
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 2
ER -
