MOGS‐CDG: quantitative analysis of the diagnostic Glc3Man tetrasaccharide and clinical spectrum of six new cases

Merel Post; Isis de Wit; Fokje S. M. Zijlstra; Udo Engelke; Arno van Rooij; John Christodoulou; Tiong Yang Tan; Anna Le Fevre; Danqun Jin; Joy Yaplito-Lee; Beom Hee Lee; Karen J. Low; Andrew Mallick; Katrin Õunap; James Pitt; William Reardon; Mari‐Anne Vals; Saskia B. Wortmann; Hans Wessels; Melissa Bärenfänger; Clara D. M. van Karnebeek; Dirk J. Lefeber

doi:10.1002/jimd.12588

MOGS‐CDG: quantitative analysis of the diagnostic Glc3Man tetrasaccharide and clinical spectrum of six new cases

Merel Post
, Isis de Wit
, Fokje S. M. Zijlstra
, Udo Engelke
, Arno van Rooij
, John Christodoulou
, Tiong Yang Tan
, Anna Le Fevre
, Danqun Jin
, Joy Yaplito-Lee
, Beom Hee Lee
, Karen J. Low
, Andrew Mallick
, Katrin Õunap
, James Pitt
, William Reardon
, Mari‐Anne Vals
, Saskia B. Wortmann
, Hans Wessels
, Melissa Bärenfänger

Clara D. M. van Karnebeek, Dirk J. Lefeber

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Survey experiments that investigate how voting procedures affect voting behavior and election outcomes use hypothetical questions and non-representative samples. We present here the results of a novel survey experiment that addresses both concerns. First, the winning party in our experiment receives a donation to its campaign funds inducing real consequences for voting. Second, we run an online experiment with a Dutch national representative sample (N = 1240). Our results validate previous findings using a representative sample, in particular that approval voting leads to a higher concentration in votes for smaller parties and strengthens centrist parties in comparison to plurality voting. Importantly, our results suggest that voting behavior is not affected by voting incentives and can be equally reliably elicited with hypothetical questions.

Original language	English
Pages (from-to)	313-325
Number of pages	13
Journal	Journal of Inherited Metabolic Disease
Volume	46
Issue number	2
Early online date	18 Jan 2023
DOIs	https://doi.org/10.1002/jimd.12588
Publication status	Published - Mar 2023
Externally published	Yes

Funding

The authors are grateful to all patients and their parents, all involved clinicians and laboratory specialists for their contributions to the study. Figures are made by Biorender. Glycomic studies were supported by ZonMw Medium Investment Grant 40‐00506‐98‐9001 and EUROGLYCAN‐omics (ERARE18‐117) by ZonMw (90030376501), under the frame of E‐Rare‐3, the ERA‐Net for Research on Rare Diseases. The research conducted at the Murdoch Children's Research Institute was supported by the State Government of Victoria's Operational Infrastructure Support Program. The Chair in Genomic Medicine awarded to JC is generously supported by The Royal Children's Hospital Foundation. Katrin Õunap and Mari‐Anne Vals are supported by Eesti Teadusagentuur grant PRG471. The research conduction at Amsterdam UMC is supported by Stichting Metakids, NL. Several author(s) (DJL, CvK, SBW) of this publication are (affiliated) members of the European Reference Network for Rare Hereditary Metabolic Disorders (MetabERN) ‐ Project ID No. 739543. The funding organizations had no role in the design or conduct of this research. The authors are grateful to all patients and their parents, all involved clinicians and laboratory specialists for their contributions to the study. Figures are made by Biorender. Glycomic studies were supported by ZonMw Medium Investment Grant 40-00506-98-9001 and EUROGLYCAN-omics (ERARE18-117) by ZonMw (90030376501), under the frame of E-Rare-3, the ERA-Net for Research on Rare Diseases. The research conducted at the Murdoch Children's Research Institute was supported by the State Government of Victoria's Operational Infrastructure Support Program. The Chair in Genomic Medicine awarded to JC is generously supported by The Royal Children's Hospital Foundation. Katrin Õunap and Mari-Anne Vals are supported by Eesti Teadusagentuur grant PRG471. The research conduction at Amsterdam UMC is supported by Stichting Metakids, NL. Several author(s) (DJL, CvK, SBW) of this publication are (affiliated) members of the European Reference Network for Rare Hereditary Metabolic Disorders (MetabERN) - Project ID No. 739543. The funding organizations had no role in the design or conduct of this research. E‐Rare, Grant/Award Number: 90030376501; Estonian Research Council, Grant/Award Number: PRG471; ZonMW Medium Investment Grant, Grant/Award Number: 40‐00506‐98‐9001; State Government of Victoria's Operational Infrastructure Support Program; The Royal Children's Hospital Foundation; Stichting Metakids Funding information

Funders	Funder number
ERA‐Net for Research on Rare Diseases
European Reference Network for Rare Hereditary Metabolic Disorders	739543
ZonMw Medium Investment
Royal Children's Hospital Foundation
Stichting Metakids
ZonMw	40‐00506‐98‐9001, ERARE18‐117, 90030376501
Eesti Teadusagentuur	PRG471
State Government of Victoria

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Post, M., Wit, I. D., Zijlstra, F. S. M., Engelke, U., Rooij, A. V., Christodoulou, J., Tan, T. Y., Fevre, A. L., Jin, D., Yaplito-Lee, J., Lee, B. H., Low, K. J., Mallick, A., Õunap, K., Pitt, J., Reardon, W., Vals, MA., Wortmann, S. B., Wessels, H., ... Lefeber, D. J. (2023). MOGS‐CDG: quantitative analysis of the diagnostic Glc3Man tetrasaccharide and clinical spectrum of six new cases. Journal of Inherited Metabolic Disease, 46(2), 313-325. https://doi.org/10.1002/jimd.12588

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title = "MOGS‐CDG: quantitative analysis of the diagnostic Glc3Man tetrasaccharide and clinical spectrum of six new cases",

abstract = "Survey experiments that investigate how voting procedures affect voting behavior and election outcomes use hypothetical questions and non-representative samples. We present here the results of a novel survey experiment that addresses both concerns. First, the winning party in our experiment receives a donation to its campaign funds inducing real consequences for voting. Second, we run an online experiment with a Dutch national representative sample (N = 1240). Our results validate previous findings using a representative sample, in particular that approval voting leads to a higher concentration in votes for smaller parties and strengthens centrist parties in comparison to plurality voting. Importantly, our results suggest that voting behavior is not affected by voting incentives and can be equally reliably elicited with hypothetical questions.",

author = "Merel Post and Wit, \{Isis de\} and Zijlstra, \{Fokje S. M.\} and Udo Engelke and Rooij, \{Arno van\} and John Christodoulou and Tan, \{Tiong Yang\} and Fevre, \{Anna Le\} and Danqun Jin and Joy Yaplito-Lee and Lee, \{Beom Hee\} and Low, \{Karen J.\} and Andrew Mallick and Katrin {\~O}unap and James Pitt and William Reardon and Mari‐Anne Vals and Wortmann, \{Saskia B.\} and Hans Wessels and Melissa B{\"a}renf{\"a}nger and Karnebeek, \{Clara D. M. van\} and Lefeber, \{Dirk J.\}",

year = "2023",

month = mar,

doi = "10.1002/jimd.12588",

language = "English",

volume = "46",

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Post, M, Wit, ID, Zijlstra, FSM, Engelke, U, Rooij, AV, Christodoulou, J, Tan, TY, Fevre, AL, Jin, D, Yaplito-Lee, J, Lee, BH, Low, KJ, Mallick, A, Õunap, K, Pitt, J, Reardon, W, Vals, MA, Wortmann, SB, Wessels, H, Bärenfänger, M, Karnebeek, CDMV & Lefeber, DJ 2023, 'MOGS‐CDG: quantitative analysis of the diagnostic Glc3Man tetrasaccharide and clinical spectrum of six new cases', Journal of Inherited Metabolic Disease, vol. 46, no. 2, pp. 313-325. https://doi.org/10.1002/jimd.12588

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T1 - MOGS‐CDG: quantitative analysis of the diagnostic Glc3Man tetrasaccharide and clinical spectrum of six new cases

AU - Post, Merel

AU - Wit, Isis de

AU - Zijlstra, Fokje S. M.

AU - Engelke, Udo

AU - Rooij, Arno van

AU - Christodoulou, John

AU - Tan, Tiong Yang

AU - Fevre, Anna Le

AU - Jin, Danqun

AU - Yaplito-Lee, Joy

AU - Lee, Beom Hee

AU - Low, Karen J.

AU - Mallick, Andrew

AU - Õunap, Katrin

AU - Pitt, James

AU - Reardon, William

AU - Vals, Mari‐Anne

AU - Wortmann, Saskia B.

AU - Wessels, Hans

AU - Bärenfänger, Melissa

AU - Karnebeek, Clara D. M. van

AU - Lefeber, Dirk J.

PY - 2023/3

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AB - Survey experiments that investigate how voting procedures affect voting behavior and election outcomes use hypothetical questions and non-representative samples. We present here the results of a novel survey experiment that addresses both concerns. First, the winning party in our experiment receives a donation to its campaign funds inducing real consequences for voting. Second, we run an online experiment with a Dutch national representative sample (N = 1240). Our results validate previous findings using a representative sample, in particular that approval voting leads to a higher concentration in votes for smaller parties and strengthens centrist parties in comparison to plurality voting. Importantly, our results suggest that voting behavior is not affected by voting incentives and can be equally reliably elicited with hypothetical questions.

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ER -

MOGS‐CDG: quantitative analysis of the diagnostic Glc3Man tetrasaccharide and clinical spectrum of six new cases

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