Molecular Basis of Antibiotic Resistance in Mycoplasma genitalium

Thomas E van der Schalk, Joyce F Braam, Johannes G Kusters*

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review


Mycoplasma genitalium is a sexually transmitted urogenital pathogen, and infection can result in serious symptoms. As M. genitalium is rather difficult to culture, infections are usually detected by molecular methods. Unfortunately, there has recently been a significant increase in resistance to azithromycin and moxifloxacin used for the treatment of M. genitalium infections. The increased resistance to (often empirically prescribed) M. genitalium treatments has resulted in frequent therapy failure, and stresses the need for routine detection of antibiotic resistance. In M. genitalium, antibiotic resistance is almost always the result of DNA mutations and thus can easily be detected by molecular techniques. Regrettably, many microbiology laboratories do not use molecular techniques for the detection of bacterial antibiotic resistance. As molecular tests are becoming available for M. genitalium, both for the establishment of infections and detection of antibiotic resistance, it is now more important to ensure that the knowledge on the resistance mechanisms is transferred from the laboratory to the clinician. This review will provide a brief summary of the current status of antibiotic resistance, their molecular mechanisms, and the impact on the current status of M. genitalium treatment.

Original languageEnglish
Article number105911
Pages (from-to)105911
JournalInternational Journal of Antimicrobial Agents
Issue number4
Early online date25 Jan 2020
Publication statusPublished - Apr 2020
Externally publishedYes

Bibliographical note

Copyright © 2020. Published by Elsevier B.V.


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