Molecular control of local translation in axon development and maintenance

Jean-Michel Cioni, Max Koppers, Christine E Holt

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

© 2018 Elsevier LtdThe tips of axons are often far away from the cell soma where most proteins are synthesized. Recent work has revealed that axonal mRNA transport and localised translation are key regulatory mechanisms that allow these distant outposts of the cell to respond rapidly to extrinsic factors and maintain axonal homeostasis. Here, we review recent evidence pointing to an increasingly broad role for local protein synthesis in controlling axon shape, synaptogenesis and axon survival by regulating diverse cellular processes such as vesicle trafficking, cytoskeletal remodelling and mitochondrial integrity. We further highlight current research on the regulatory mechanisms that coordinate the localization and translation of functionally linked mRNAs in axons.
Original languageEnglish
Pages (from-to)86-94
JournalCurrent Opinion in Neurobiology
Volume51
DOIs
Publication statusPublished - 1 Aug 2018
Externally publishedYes

Funding

The authors wish to apologize to colleagues whose work could not be cited due to space limitations. J-MC is supported by European Research Council Advanced Grant to C.E.H. ( 322817 ), MK by the Netherlands Organization for Scientific Research (NWO Rubicon 019.161LW.033). The authors wish to apologize to colleagues whose work could not be cited due to space limitations. J-MC is supported by European Research Council Advanced Grant to C.E.H. (322817), MK by the Netherlands Organization for Scientific Research (NWO Rubicon 019.161LW.033).

FundersFunder number
Organization for Autism Research
Seventh Framework Programme322817
European Research Council
Nederlandse Organisatie voor Wetenschappelijk Onderzoek019.161LW.033

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